{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:32:53Z","timestamp":1740126773103,"version":"3.37.3"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Speicheldr\u00fcsenkarzinome sind selten und heterogen. \u00dcber 20 Subtypen sind anerkannt und Risikofaktoren sind vielf\u00e4ltig. Ziel dieser Arbeit war die Bewertung des Subtyps und weiterer Risikofaktoren bei einem monozentrischen Kollektiv aus \u00fcber vier Jahrzehnten.<\/jats:p><jats:p>\n          Material und Methoden 205 F\u00e4lle (Diagnosezeitraum 1972\u20132014) wurden retrospektiv erhoben und hinsichtlich der Verteilung von Risikofaktoren und deren Einfluss auf die Gesamt\u00fcberlebenszeit (overall survival, OS) statistisch ausgewertet.<\/jats:p><jats:p>\n          Ergebnisse 19\/24 (79,2%) der in der WHO-Klassifikation gelisteten Subtypen kamen in der Kohorte selten vor (&lt; 5%). Davon wurden 10\/24 (41,7%) Subtypen nie diagnostiziert. Das Plattenepithelkarzinom (PEC), Adenokarzinom (AdenoCa), Azinuszellkarzinom (AzinusCa), Mukoepidermoidkarzinom (MEC) und adenoidzystische Karzinom (ACC) sind mit zusammen 145\/205 (70,7%) die mit Abstand h\u00e4ufigsten Subtypen. Risikofaktoren sind in diesen Gruppen signifikant unterschiedlich vertreten (z.B. lymphogene Metastasierung und Differenzierungsgrad beim AdenoCa und Alter, T- und UICC-Stadium beim PEC). Das 5-Jahres Gesamt\u00fcberleben aller Patienten war 66,9% und unterscheidet sich signifikant innerhalb der h\u00e4ufigsten Subtypen. Ein unabh\u00e4ngiger Einfluss auf das Gesamt\u00fcberleben war in der multivariaten Analyse feststellbar f\u00fcr das Alter der Patienten (p&lt;0,001), sowie das T- (p=0,003) und N-Stadium (p=0,046).<\/jats:p><jats:p>\n          Schlussfolgerungen Die meisten Subtypen traten auch innerhalb von Jahrzehnten ausgesprochen selten oder gar nicht auf. Die h\u00e4ufigsten Diagnosen unterscheiden sich bez\u00fcglich der Risikofaktoren als auch hinsichtlich des OS, so dass 3 Risikogruppen gebildet werden k\u00f6nnen. Schlussfolgernd ist die Betrachtung von TNM alleine f\u00fcr die Prognoseabsch\u00e4tzung beim Speicheldr\u00fcsenkarzinom unzureichend.<\/jats:p>","DOI":"10.1055\/a-1976-9694","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T23:50:01Z","timestamp":1671666601000},"source":"Crossref","is-referenced-by-count":0,"title":["Speicheldr\u00fcsenkarzinome \u2013 Monozentrische Erfahrung zu Subtypen und deren Inzidenz \u00fcber 42 Jahre"],"prefix":"10.1055","author":[{"given":"Christian","family":"Krauss","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie, Justus Liebig Universit\u00e4t Giessen, Fachbereich Medizin, Giessen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-1601","authenticated-orcid":false,"given":"Steffen","family":"Wagner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie, Justus Liebig Universit\u00e4t Giessen, Fachbereich Medizin, Giessen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens-Peter","family":"Klu\u00dfmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie, Justus Liebig Universit\u00e4t Giessen, Fachbereich Medizin, Giessen, Deutschland"},{"name":"Medizinische Fakult\u00e4t, Klinik f\u00fcr Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie, Universit\u00e4t zu K\u00f6ln, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rn","family":"Pons-K\u00fchnemann","sequence":"additional","affiliation":[{"name":"Medizinische Statistik, Institut f\u00fcr Medizinische Informatik, Justus Liebig Universit\u00e4t Giessen, Fachbereich Medizin, Giessen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Arens","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie, Justus Liebig Universit\u00e4t Giessen, Fachbereich Medizin, Giessen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-2931","authenticated-orcid":false,"given":"Christine","family":"Langer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie, Justus Liebig Universit\u00e4t Giessen, Fachbereich Medizin, Giessen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Wittekindt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie, Justus Liebig Universit\u00e4t Giessen, Fachbereich Medizin, Giessen, Deutschland"},{"name":"Klinik f\u00fcr HNO-Heilkunde, Universit\u00e4t Witten\/Herdecke Department f\u00fcr Humanmedizin, Witten, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00292-017-0407-5","article-title":"Updates on tumours of the salivary glands : 2017 WHO classification","volume":"39","author":"S Ihrler","year":"2018","journal-title":"Pathologe"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1002\/hed.10400","article-title":"Salivary gland carcinoma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck oncology cooperative group","volume":"26","author":"CH Terhaard","year":"2004","journal-title":"Head Neck discussion 692\u2013683"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.oraloncology.2011.09.005","article-title":"Salivary gland carcinoma in Denmark 1990\u20132005: outcome and prognostic factors. 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