{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:05:00Z","timestamp":1782849900701,"version":"3.54.5"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"National Key Research and Development Program in China","award":["2016YFC1300202"],"award-info":[{"award-number":["2016YFC1300202"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central\n                        Universities","doi-asserted-by":"crossref","award":["20211001"],"award-info":[{"award-number":["20211001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the effects of 12-week brisk walking on chronotropic response in\n                    hypertensive patients aged 40\u201369. 77 participants in exercise group\n                    underwent 12-week brisk walking, while 66 participants in control group received\n                    health education. Chronotropic parameters, resting blood pressure, and physical\n                    fitness including peak oxygen consumption (VO2peak) were measured.\n                    After 12 weeks, the systolic blood pressure (SBP) was decreased\n                    (\u22126.104\u2009mmHg, 95%CI \u22128.913 to\n                    \u22123.295\u2009mmHg, P&lt;0.0001), while metabolic chronotropic\n                    relationship (MCR) slope and VO2peak were increased (0.073,\n                    95%CI 0.001 to 0.145, P=0.046;\n                    1.756\u2009mL\/kg\/min, 95%CI 0.891 to\n                    2.622\u2009mL\/kg\/min, P&lt;0.0001) in exercise group\n                    compared to baseline. The chronotropic response index (CRI) at\n                    25\u201375\u2009W load were decreased (\u22120.210, 95%CI\n                    \u22120.307 to \u22120.112, P&lt;0.0001; \u22120.144,\n                    95%CI \u2212\u20090.204 to \u22120.083, P&lt;0.0001;\n                    \u22120.078, 95%CI \u22120.135 to \u22120.022, P=0.007)\n                    in control group after 12 weeks. The relative changes (%\u0394) of\n                    systolic and diastolic blood pressure were negatively correlated with\n                        %\u0394VO2peak (r=\u22120.233,\n                    r=\u22120.187), while %\u0394MCR and %\u0394CRI\n                    at 50\u201375\u2009W load were positively correlated with\n                        %\u0394VO2peak after 12 weeks (r=0.330,\n                    r=0.282, r\u2009=0.370). %\u0394SBP was also\n                    positively correlated with %\u0394MCR (r =\u22120.213). In\n                    conclusion, 12-week brisk walking reduced SBP by improving chronotropic response\n                    in hypertensive patients aged 40\u201369. The enhanced chronotropic response\n                    was associated with enhanced cardiorespiratory fitness.<\/jats:p>","DOI":"10.1055\/a-1978-5907","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T05:52:58Z","timestamp":1668491578000},"page":"376-384","source":"Crossref","is-referenced-by-count":1,"title":["12-week Brisk Walking Improved Chronotropic Response in Hypertensive\n                    Patients"],"prefix":"10.1055","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7040-7568","authenticated-orcid":false,"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Sport Medicine and Rehabilitation, Beijing Sport University,\n                    Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Sport Medicine and Rehabilitation, Beijing Sport University,\n                    Beijing, China"},{"name":"College of Physical Education, Guangxi University, Nanning,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Sport Medicine and Rehabilitation, Beijing Sport University,\n                    Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Sport Medicine and Rehabilitation, Beijing Sport University,\n                    Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Sport Medicine and Rehabilitation, Beijing Sport University,\n                    Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"ref1","first-page":"24","article-title":"2018 Chinese guidelines for the management of hypertension","volume":"24","year":"2019","journal-title":"Chin J Cardiovasc Med"},{"key":"ref2","first-page":"833","volume":"35","year":"2020","journal-title":"Chin Circ J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0140-6736(16)31679-8","volume":"388","year":"2016","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0140-6736(14)60685-1","article-title":"Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks,\n                    healthy life-years lost, and age-specific associations in 1.25 million\n                    people","volume":"383","author":"E Rapsomaniki","year":"2014","journal-title":"Lancet"},{"key":"ref5","first-page":"582","volume":"19","year":"2021","journal-title":"Chin J Cardiovasc Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"493","DOI":"10.7326\/0003-4819-136-7-200204020-00006","article-title":"Effect of aerobic exercise on blood pressure: a meta-analysis of randomized,\n                    controlled trials","volume":"136","author":"S P Whelton","year":"2002","journal-title":"Ann Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/2786120","article-title":"The effect of exercise on the older adult's blood pressure suffering\n                    hypertension: systematic review and meta-analysis on clinical trial studies","volume":"2020","author":"M Kazeminia","year":"2020","journal-title":"Int J Hypertens"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1038\/s41598-020-64365-x","article-title":"Different exercise training modalities produce similar endothelial function\n                    improvements in individuals with prehypertension or hypertension: a randomized\n                    clinical trial exercise, endothelium and blood pressure","volume":"10","author":"M L Pedralli","year":"2020","journal-title":"Sci Rep"},{"key":"ref9","first-page":"1","article-title":"Does exercise training improve the function of vascular smooth muscle? A\n                    systematic review and meta-analysis","volume":"18","author":"Y Liu","year":"2021","journal-title":"Res Sports Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/ajh\/hpz115","article-title":"Exercise prevents hypertension and disrupts the correlation between vascular\n                    sympathetic activity and age\u2011related increase in blood pressure in SHRs","volume":"32","author":"J Y Li","year":"2019","journal-title":"Am J Hypertens"},{"key":"ref11","first-page":"988","article-title":"Chronotropic response and heart rate variability in patients with essential\n                    hypertension","volume":"15","author":"H Pan","year":"2007","journal-title":"Chin J Hypertens"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1161\/CIRCULATIONAHA.110.940577","article-title":"Chronotropic incompetence causes, consequences, and management","volume":"123","author":"P H Brubaker","year":"2011","journal-title":"Circulation"},{"key":"ref13","first-page":"340","article-title":"Increased vascular tone due to sympathovagal imbalance in normotensive and\n                    prehypertensive offspring of hypertensive parents","volume":"31","author":"G K Pal","year":"2012","journal-title":"Int Angiol"},{"key":"ref14","first-page":"357","article-title":"Study of sympathovagal imbalance by spectral analysis of heart rate variability\n                    in young prehypertensives","volume":"55","author":"G K Pal","year":"2011","journal-title":"Indian J Physiol Pharmacol"},{"key":"ref15","first-page":"175","article-title":"Effects of exercise training on chronotropic function in patients with essential\n                    hypertension","volume":"28","author":"A Song","year":"2009","journal-title":"J Cardiovasc Pulm Dis"},{"key":"ref16","first-page":"87","article-title":"Heart rate recovery and chronotropic incompetence in patients with\n                    prehypertension","volume":"106","author":"K Shin","year":"2015","journal-title":"Minerva Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jama.281.6.524","article-title":"Impaired chronotropic response to exercise stress testing as a predictor of\n                    mortality","volume":"281","author":"M S Lauer","year":"1999","journal-title":"JAMA"},{"key":"ref18","first-page":"1","article-title":"Exercise chronotropic incompetence phenotypes the level of cardiovascular risk\n                    and exercise gas exchange impairment in the general population. An analysis of\n                    the Euro-EX prevention trial","volume":"0","author":"P Laforgia","year":"2019","journal-title":"Eur J Prev Cardiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0002-9149(00)01036-5","article-title":"Usefulness of impaired chronotropic response to exercise as a predictor of\n                    mortality, independent of the severity of coronary artery disease","volume":"86","author":"T J Dresing","year":"2000","journal-title":"Am J Cardiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1136\/hrt.81.4.398","article-title":"The functional significance of chronotropic incompetence during dobutamine\n                    stress test","volume":"81","author":"A Elhendy","year":"1999","journal-title":"Heart"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1161\/01.CIR.94.12.3226","article-title":"Chronotropic response to exercise: improved performance of ST-depression\n                    criteria after adjustment for heart rate reserve","volume":"94","author":"P M Okin","year":"1996","journal-title":"Circulation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0733-8651(18)30211-X","article-title":"Exercise testing for chronotropic assessment","volume":"10","author":"B L Wilkoff","year":"1992","journal-title":"Cardiol Clin"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"552","DOI":"10.7326\/0003-4819-132-7-200004040-00007","article-title":"Heart rate recovery after submaximal exercise testing as a predictor of\n                    mortality in a cardiovascularly healthy cohort","volume":"132","author":"C R Cole","year":"2000","journal-title":"Ann Intern Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0002-9149(02)02706-6","article-title":"Heart rate recovery after treadmill exercise testing and risk of cardiovascular\n                    disease events (The Framingham Heart Study)","volume":"90","author":"A Morshedi-Meibodi","year":"2002","journal-title":"Am J Cardiol"},{"key":"ref25","first-page":"548","article-title":"Value of chronotropic incompetence of heart in patients with essential\n                    hypertension","volume":"16","author":"B Li","year":"2007","journal-title":"Chin J Cardiovasc Rehabil Med"},{"key":"ref26","first-page":"239","article-title":"Analysis of the chronotropic response change in patients with essential\n                    hypertension (EH) and essential hypertension complicated with diabetes mellitus\n                    (DM)","volume":"9","author":"Y Wu","year":"2009","journal-title":"Prev Treat Cardio-Cerebral-Vasc Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/ptj\/86.5.626","article-title":"Effects of exercise training on heart rate variability after coronary\n                    angioplasty","volume":"86","author":"M W Tsai","year":"2006","journal-title":"Phys Ther"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/HJR.0b013e3283316cd1","article-title":"Vigorous physical activity and vagal modulation in young adults","volume":"16","author":"L Soares-Miranda","year":"2009","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"ref29","volume-title":"Combined Thera-Band Resistance Training with Aerobic Exercise on Heart\n                    Chronotropic Response Index Effects of Elderly Patients with Essential\n                    Hypertension [M]","author":"Y. Huang","year":"2014"},{"key":"ref30","volume-title":"Research on Methods of Evaluating Male College Students' Aerobic\n                    Capacity by Heart Rate Recovery after Exercise [D]","author":"C. Zhu","year":"2018"},{"key":"ref31","volume-title":"Brisk walking Effect Assessment for 40\u201349 years Old Adults in China\n                    [D]","author":"X. Li","year":"2011"},{"key":"ref32","volume-title":"ACSM's Guidelines for Exercise Testing and Prescription. 10th ed","author":"D Riebe","year":"2017"},{"key":"ref33","first-page":"836","article-title":"Advance on the influence of different exercise modes on cardiorespiratory\n                    fitness of hypertensive patients","volume":"21","author":"Y Yan","year":"2020","journal-title":"Chin Prev Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/HYPERTENSIONAHA.112.196493","article-title":"Exercise capacity and progression from prehypertension to hypertension","volume":"60","author":"C Faselis","year":"2012","journal-title":"Hypertension"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/ajh.2009.6","article-title":"The Association of cardiorespiratory fitness and physical activity with\n                    incidence of hypertension in men","volume":"22","author":"N L Chase","year":"2009","journal-title":"Am J Hypertens"},{"key":"ref36","first-page":"47","article-title":"Mean level of blood pressure and rate of hypertension among people with\n                    different levels of body mass index and waist circumference","volume":"6","author":"L Zhao","year":"2003","journal-title":"Chin J Epidemiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1097\/GME.0000000000001085","article-title":"Effects of dietary and exercise intervention on weight loss and body composition\n                    in obese postmenopausal women: a systematic review and meta-analysis","volume":"25","author":"C C Cheng","year":"2018","journal-title":"Menopause"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e004473","DOI":"10.1161\/JAHA.112.004473","article-title":"Exercise training for blood pressure: a systematic review and meta-analysis","volume":"2","author":"V A Cornelissen","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"ref39","first-page":"615","article-title":"Is systolic blood pressure important or diastolic blood pressure important? How\n                    to treat isolated systolic hypertension and isolated diastolic\n                    hypertension?","volume":"27","author":"X. Chi","year":"2019","journal-title":"Chin J Hypertens"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1186\/s12889-021-11686-9","article-title":"The different risk factors for isolated diastolic hypertension and isolated\n                    systolic hypertension: a national survey","volume":"21","author":"K Xie","year":"2021","journal-title":"BMC Public Health"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/1474515116684407","article-title":"Effectiveness of endurance exercise training in patients with coronary artery\n                    disease: A meta-analysis of randomised controlled trials","volume":"16","author":"Y C Chen","year":"2017","journal-title":"Eur J Cardiovasc Nurs"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/01.CIR.103.9.1245","article-title":"Does the relation of blood pressure to coronary heart disease risk change with\n                    aging? The Framingham Heart Study","volume":"103","author":"S S Franklin","year":"2001","journal-title":"Circulation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1161\/01.CIR.93.8.1520","article-title":"Impaired heart rate response to graded exercise: Prognostic implications of\n                    chronotropic incompetence in the Framingham Heart Study","volume":"93","author":"M S Lauer","year":"1996","journal-title":"Circulation"},{"key":"ref44","first-page":"H132","article-title":"Modulation of cardiac autonomic activity during and immediately after\n                    exercise","volume":"256","author":"Y Arai","year":"1989","journal-title":"Am J Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/HYPERTENSIONAHA.108.127027","article-title":"Exercise capacity and mortality in hypertensive men with and without additional\n                    risk factors","volume":"53","author":"P Kokkinos","year":"2009","journal-title":"Hypertension"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.cjca.2012.01.001","article-title":"The obesity epidemic and its impact on hypertension","volume":"28","author":"T Nguyen","year":"2012","journal-title":"Can J Cardiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/hr.2012.85","article-title":"Supervised walking groups to increase physical activity in elderly women with\n                    and without hypertension: effect on pulse wave velocity","volume":"35","author":"F Fantin","year":"2012","journal-title":"Hyperten Res"},{"key":"ref48","first-page":"1139","article-title":"Provincial disparities in the burden of cardiovascular diseases attributable to\n                    general, abdominal and visceral adiposity: result from a recent national\n                    representative study","volume":"19","author":"Y Tian","year":"2021","journal-title":"Chin J Cardiovasc Res"},{"key":"ref49","first-page":"767","article-title":"Relationship of obesity and arterial stiffness in elderly population in\n                    community","volume":"42","author":"J Gu","year":"2016","journal-title":"Jiangsu Med J"},{"key":"ref50","volume-title":"Correlation Between Body Composition and Arteriosclerosis in Elderly Patients\n                    with Hypertension [M]","author":"R. Ji","year":"2021"},{"key":"ref51","first-page":"193","article-title":"Relationship between body mass index and waist circumference for the\n                    cardiovascular disease risk factors","volume":"12","author":"M Yu","year":"2010","journal-title":"Chin J Health Care Med"}],"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1978-5907.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T23:30:04Z","timestamp":1683070204000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1978-5907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,14]]},"references-count":51,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2023,5,2]]},"published-print":{"date-parts":[[2023,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1978-5907","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11,14]]},"published":{"date-parts":[[2022,11,14]]}}}