{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:48:41Z","timestamp":1776275321551,"version":"3.50.1"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"JSPS KAKENHI","award":["JP20H03564"],"award-info":[{"award-number":["JP20H03564"]}]},{"name":"Sukoyaka Grant for Maternal and Child Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to evaluate whether elevated urine desmosine levels at 3 weeks of age were associated with severe radiological findings, bronchopulmonary dysplasia (BPD), and post-prematurity respiratory disease (PRD) in extremely preterm (EP) or extremely low birth weight (ELBW) infants.<\/jats:p><jats:p>\n            Study Design\u2003This study recruited 37 EP (22\u201327 completed weeks) or ELBW (&lt;1,000\u2009g) infants. Urine was collected between 21 and 28 postnatal days, and desmosine was measured using an enzyme-linked immunosorbent assay kit; the urine creatinine level was also measured. Bubbly\/cystic lungs were characterized by emphysematous chest X-rays on postnatal day 28. Furthermore, provision of supplemental oxygen or positive-pressure respiratory support at 40 weeks' postmenstrual age defined BPD, and increased medical utilization at 18 months of corrected age defined PRD. The desmosine\/creatinine threshold was determined by receiver operating characteristic analysis. The adjusted risk and 95% confidence interval (CI) for elevated urine desmosine\/creatinine levels were estimated by logistic regression analysis.<\/jats:p><jats:p>\n            Results\u2003Elevated urine desmosine\/creatinine levels higher than the threshold were significantly associated with bubbly\/cystic lungs (8\/13 [61.5%] vs. 2\/24 [8.3%], p\u2009=\u20090.001), BPD (10\/13 [76.9%] vs. 8\/24 [33.3%], p\u2009=\u20090.02), and PRD (6\/13 [46.2%] vs. 2\/24 [8.3%], p\u2009=\u20090.01). After adjusting for gestational age, birth weight, and sex, the urine desmosine\/creatinine levels were significantly higher in those who were highly at risk of bubbly\/cystic lungs (odds ratio [OR], 13.2; 95% CI, 1.67\u2013105) and PRD (OR, 13.8; 95% CI, 1.31\u2013144).<\/jats:p><jats:p>\n            Conclusion\u2003Elevated urine desmosine\/creatinine levels on the third postnatal week were associated with bubbly\/cystic lungs on day 28 and PRD at 18 months of corrected age in EP or ELBW infants.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1979-8501","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:33:51Z","timestamp":1668645231000},"page":"e1030-e1036","source":"Crossref","is-referenced-by-count":2,"special_numbering":"S","title":["Urine Desmosine as a Novel Biomarker for Bronchopulmonary Dysplasia and Postprematurity Respiratory Disease in Extremely Preterm or Low Birth Weight Infants"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3148-9892","authenticated-orcid":false,"given":"Katsuya","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Osaka Women's and Children's Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Yanagihara","sequence":"additional","affiliation":[{"name":"Department of Developmental Medicine, Research Institute, Osaka Women's and Children's Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41572-019-0127-7","article-title":"Bronchopulmonary dysplasia","volume":"5","author":"B Th\u00e9baud","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jpeds.2018.01.043","article-title":"Bronchopulmonary dysplasia: executive summary of a workshop","volume":"197","author":"R D Higgins","year":"2018","journal-title":"J Pediatr"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/jcm9051539","article-title":"Present and future of bronchopulmonary dysplasia","volume":"9","author":"L Bonadies","year":"2020","journal-title":"J Clin Med"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1053\/j.semperi.2018.09.013","article-title":"An update on pulmonary and neurodevelopmental outcomes of bronchopulmonary dysplasia","volume":"42","author":"J LY Cheong","year":"2018","journal-title":"Semin Perinatol"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMoa1700827","article-title":"Ventilation in extremely preterm infants and respiratory function at 8 years","volume":"377","author":"L W Doyle","year":"2017","journal-title":"N Engl J Med"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1164\/rccm.201812-2348OC","article-title":"The diagnosis of bronchopulmonary dysplasia in very preterm infants. 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