{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:51:33Z","timestamp":1785808293850,"version":"3.56.0"},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Central Government Guides Local Science and Technology Development","award":["2021Szvup073"],"award-info":[{"award-number":["2021Szvup073"]}]},{"name":"Science and Technology Innovation Project of Jinan City","award":[".201602153,202019193"],"award-info":[{"award-number":[".201602153,202019193"]}]},{"name":"Major Research and Development Project of Shandong Province","award":["ZR2020MH041"],"award-info":[{"award-number":["ZR2020MH041"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81170274,82170462"],"award-info":[{"award-number":["81170274,82170462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural fund project of Shandong Province","award":["G201703080074"],"award-info":[{"award-number":["G201703080074"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Background\u2003Obesity, especially abdominal obesity, is an independent indicator of increased cardiovascular risk. Observational studies have shown an observational association between obesity and venous thromboembolism (VTE). As a type of VTE, pulmonary embolism (PE) is also associated with obesity. However, it is unclear whether the observed associations are causal or caused by confounding bias or reverse causality.<\/jats:p><jats:p>Methods\u2003We performed a two-sample test by obtaining the exposure dataset of waist circumference (WC) and hip circumference (HC) from the Neale Laboratory Consortium's genome-wide association study summary data and the summary-level outcome data of VTE and PE from FinnGen Biobank of European ancestry to determine the causal effect of WC and HC on VTE and PE.<\/jats:p><jats:p>Results\u2003All three Mendelian randomization methods displayed a positive association between WC\/HC and VTE\/PE. WC and HC were positively associated with VTE (odds ratio [OR]\u2009=\u20091.803 per 1 standard deviation [SD] increase in WC, 95% confidence interval [CI]\u2009=\u20091.393\u20132.333; p\u2009&lt;\u20090.001; OR\u2009=\u20091.479 per 1 SD increase in HC, 95% CI\u2009=\u20091.219\u20131.796; p\u2009&lt;\u20090.001, respectively). Furthermore, we found a causal association between genetically predicted WC\/HC and a higher risk of PE (OR\u2009=\u20091.929 per 1 SD increase in WC, 95% CI\u2009=\u20091.339\u20132.778, p\u2009&lt;\u20090.001; OR\u2009=\u20091.431 per 1 SD increase in HC, 95% CI =1.095\u20131.869; p\u2009=\u20090.009, respectively).<\/jats:p><jats:p>Conclusion\u2003There is a significant causal relationship between WC\/HC and VTE\/PE, which is consistent with observational studies. Taking measures to reduce WC\/HC of obesity may help reduce the incidence of VTE\/PE.<\/jats:p>","DOI":"10.1055\/a-1980-8852","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:29:50Z","timestamp":1668644990000},"page":"347-361","source":"Crossref","is-referenced-by-count":22,"title":["Genetic Predisposition of Both Waist Circumference and Hip Circumference Increased the Risk of Venous Thromboembolism"],"prefix":"10.1055","volume":"123","author":[{"given":"Jiayu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Hospital of Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangshan","family":"Tan","sequence":"first","affiliation":[{"name":"Key Laboratory of Pulmonary Vascular Medicine, National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Hua","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pulmonary Vascular Medicine, National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiping","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Hospital of Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of Xiamen University, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Hospital of Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1182\/blood.2019000919","article-title":"Novel antithrombotic strategies for treatment of venous thromboembolism","volume":"135","author":"J I Weitz","year":"2020","journal-title":"Blood"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chest.2018.01.035","article-title":"Management of low-risk pulmonary embolism patients without hospitalization: the low-risk pulmonary embolism prospective management study","volume":"154","author":"J R 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