{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:57:58Z","timestamp":1790539078331,"version":"4.1.0"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"Austrian Heart Fund","award":["202003"],"award-info":[{"award-number":["202003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n            Background\u2003The ABO blood group system is linked to hemostasis via its relationship with von Willebrand factor (VWF) and factor VIII (FVIII). In the current study, we investigated the association of the ABO system with clinical outcomes as well as VWF and platelet function in patients with left ventricular assist devices (LVADs).<\/jats:p><jats:p>\n            Methods\u2003Bleeding and thromboembolic complications were assessed in 111 patients during 1 year after LVAD implantation. In 67 LVAD patients, VWF antigen, VWF activity, VWF ristocetin cofactor, VWF collagen-binding, and FVIII activity were assessed. Platelet surface P-selectin and activated glycoprotein IIb\/IIIa were determined by flow cytometry, and soluble P-selectin was measured with an enzyme-linked immunoassay. Platelet aggregation was assessed by light transmission and impedance aggregometry.<\/jats:p><jats:p>\n            Results\u2003Thirty-six patients (32.4%) experienced a bleeding and 22 patients (19.8%) a thromboembolic event. In univariate analyses, patients with blood group O had numerically more bleeding complications and less thromboembolic events as compared to patients with blood group non-O (both p \u2265 0.05). After multivariable adjustment, blood group O was significantly associated with a higher risk of bleeding (hazard ratio 2.42 [95% confidence interval 1.03\u20135.70], p\u2009=\u20090.044) but not linked to thromboembolic complications.<\/jats:p><jats:p>\n            Conclusion\u2003Patients with blood group O had significantly lower levels of VWF and FVIII (all p\u2009&lt;\u20090.05), whereas P-selectin expression in response to thrombin-receptor activating peptide and soluble P-selectin were higher as compared to patients with blood group non-O (both p\u2009&lt;\u20090.05). LVAD patients with blood group O are at an increased bleeding risk, potentially due to lower VWF and FVIII levels.<\/jats:p>","DOI":"10.1055\/a-1983-0676","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T23:30:10Z","timestamp":1668900610000},"page":"336-346","source":"Crossref","is-referenced-by-count":8,"title":["Impact of ABO Blood Group on Thromboembolic and Bleeding Complications in Patients with Left Ventricular Assist Devices"],"prefix":"10.1055","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-628X","authenticated-orcid":false,"given":"Maximilian","family":"Tscharre","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cardiology and Nephrology, Landesklinikum Wiener Neustadt, Wiener Neustadt, Austria"},{"name":"Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Kitzmantl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schl\u00f6glhofer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Cichra","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Eichelberger","sequence":"additional","affiliation":[{"name":"Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia P.","family":"Wadowski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Laufer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Panzer","sequence":"additional","affiliation":[{"name":"Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zimpfer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gremmel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Internal Medicine I, Cardiology and Intensive Care Medicine, Landesklinikum Mistelbach-G\u00e4nserndorf, Mistelbach, Austria"},{"name":"Institute of Cardiovascular Pharmacotherapy and Interventional Cardiology, Karl Landsteiner Society, St. P\u00f6lten, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.athoracsur.2021.12.011","article-title":"Twelfth Interagency Registry for Mechanically Assisted Circulatory Support Report: readmissions after left ventricular assist device","volume":"113","author":"P Shah","year":"2022","journal-title":"Ann Thorac Surg"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/ejcts\/ezz098","article-title":"2019 EACTS Expert Consensus on long-term mechanical circulatory support","volume":"56","author":"E V Potapov","year":"2019","journal-title":"Eur J Cardiothorac 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