{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:00:06Z","timestamp":1756810806802},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose To investigate parameters of retinal and choroidal microcirculation quantitatively with optical coherence tomography angiography (OCTA) in high myopic children, and to\n          explore potential correlations with age, axial length (AL), spherical equivalent (SE), and central retinal thickness (CRT).<\/jats:p><jats:p>\n          Methods En face angiograms were generated with an OCTA device and evaluated with automated density and flow analyzer algorithms. Perfusion parameters were correlated with age, AL,\n          SE, and CRT using Spearman\u02bcs rank correlation analysis. Repeatability and reproducibility of perfusion parameter measurements were calculated in a high myopic cohort.<\/jats:p><jats:p>\n          Results Repeatability and reproducibility of OCTA measurements were good, ranging from 3.6\u200a\u2013\u200a6.5%. Strong positive correlation was identified between age and CRT (rho\u2009=\u20090.673,\n          p\u2009=\u20090.00) as well as between AL and SE (rho\u2009=\u20090.844, p\u2009=\u20090.00). There was a strong negative correlation between AL and choriocapillary flow density (CCFD) (rho\u2009=\u2009\u2212\u20090.612, p\u2009=\u20090.00), and a\n          moderate negative correlation between age and superficial parafoveal retinal vessel density (SPRVD) as well as CCFD (rho\u2009=\u2009\u2212\u20090.497, p\u2009=\u20090.013 and rho\u2009=\u2009\u2212\u20090.483, p\u2009=\u20090.023, respectively).<\/jats:p><jats:p>\n          Conclusion OCTA appears to be a reliable tool for the quantitative investigation of retinal and choroidal microcirculation in a high myopic pediatric cohort. CCFD reduction was\n          associated with increasing AL in this cohort.<\/jats:p>","DOI":"10.1055\/a-1992-1323","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:21:35Z","timestamp":1670026895000},"page":"1084-1090","source":"Crossref","is-referenced-by-count":1,"title":["Choriocapillary Flow Correlation with Axial Length in High Myopia \u2013 An Angiography Study with Optical Coherence Tomography"],"prefix":"10.1055","volume":"240","author":[{"given":"No\u00e9mi","family":"Sz\u00e9ll","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ken\u00e9zy Gyula Campus, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna Z.","family":"Orosz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Facsk\u00f3","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Sohajda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ken\u00e9zy Gyula Campus, Faculty of Medicine, University of Debrecen, Debrecen, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e81499","DOI":"10.1371\/journal.pone.0081499","article-title":"Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography","volume":"8","author":"W Choi","year":"2013","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21037\/aes.2018.01.03","article-title":"Pathologic myopia","volume":"3","author":"K Ohno-Matsui","year":"2018","journal-title":"Ann Eye Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00417-018-4012-y","article-title":"Vessel density, retinal thickness, and choriocapillaris vascular flow in myopic eyes on OCT angiography","volume":"256","author":"P Milani","year":"2018","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00417-003-0836-0","article-title":"Reduction of retinal blood flow in high myopia","volume":"242","author":"N Shimada","year":"2014","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00417-010-1407-9","article-title":"Ocular blood flow measurements in healthy human myopic eyes","volume":"248","author":"A Benavente-P\u00e9rez","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref6","first-page":"113","article-title":"Choroidal and retinal blood flow changes in degenerative myopia","volume":"31","author":"N Akyol","year":"1996","journal-title":"Can J Ophthalmol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0002-9394(14)70484-2","article-title":"Indocyanine green angiographic features of pathologic myopia","volume":"122","author":"M Quaranta","year":"1996","journal-title":"Am J Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e010791","DOI":"10.1136\/bmjopen-2015-010791","article-title":"Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study","volume":"6","author":"X Wang","year":"2016","journal-title":"BMJ Open"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.ophtha.2014.01.021","article-title":"Optical coherence tomography angiography of optic disc perfusion in glaucoma","volume":"121","author":"Y Jia","year":"2014","journal-title":"Ophthalmology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00417-015-3095-y","article-title":"Correlation between optic disc perfusion and glaucomatous severity in patients with open-angle glaucoma: an optical coherence tomography angiography study","volume":"253","author":"X Wang","year":"2015","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e81343","DOI":"10.1371\/journal.pone.0081343","article-title":"Parafoveal retinal vascular response to pattern visual stimulation assessed with OCT angiography","volume":"8","author":"E Wei","year":"2013","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1167\/iovs.14-16270","article-title":"Macular perfusion in healthy Chinese: an\u00a0optical coherence tomography angiogram study","volume":"56","author":"J Yu","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1167\/iovs.16-21289","article-title":"Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes","volume":"58","author":"M Al-Sheikh","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e013571","DOI":"10.1136\/bmjopen-2016-013571","article-title":"Vascular flow density in pathological myopia: an optical coherence tomography angiography study","volume":"7","author":"J Mo","year":"2017","journal-title":"BMJ Open"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.3928\/23258160-20190503-13","article-title":"Choriocapillary Blood Flow in Myopic Subjects Measured With OCT Angiography","volume":"50","author":"P Scherm","year":"2019","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF00170692","article-title":"Factors influencing the ocular pulse\u2013axial length","volume":"229","author":"C B James","year":"1991","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ajo.2012.07.015","article-title":"The relationship between axial length and choroidal thickness in eyes with high myopia","volume":"155","author":"I Flores-Moreno","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12886-018-0791-5","article-title":"Correlation of 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Offers New Insights into Choriocapillaris Perfusion","volume":"239","author":"J L Lauermann","year":"2018","journal-title":"Ophthalmologica"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/IAE.0000000000001324","article-title":"Choroidal blood visualization in high myopia using a projection artifact method in optical coherence tomography angiography","volume":"37","author":"I Maruko","year":"2017","journal-title":"Retina"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1167\/iovs.15-16542","article-title":"In Vivo Foveal Development Using Optical Coherence Tomography","volume":"56","author":"H Lee","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1097\/IAE.0000000000000464","article-title":"Macular retinal layer thickness in childhood","volume":"35","author":"S A 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Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1992-1323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:22:42Z","timestamp":1693869762000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1992-1323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,2]]},"references-count":27,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2023,9,4]]},"published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1992-1323","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12,2]]},"published":{"date-parts":[[2022,12,2]]}}}