{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:55:26Z","timestamp":1778644526905,"version":"3.51.4"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"name":"Respiratory Research Project of National Clinical Research Center for Respiratory Diseases","award":["HXZX-20210201"],"award-info":[{"award-number":["HXZX-20210201"]}]},{"name":"Beijing Hospitals Authority\u2019 Ascent Plan","award":["DFL20191201"],"award-info":[{"award-number":["DFL20191201"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003To explore the neural difference between children with obstructive sleep apnea (OSA) and healthy controls, together with the relation between this difference and clinical severity indicator of children with OSA.<\/jats:p><jats:p>\n          Methods\u2003Twenty-seven children with OSA (7.6\u2009\u00b1\u20092.5 years, apnea hypopnea index [AHI]: 9.7\u2009\u00b1\u20095.3 events\/h) and 30 healthy controls (7.8\u2009\u00b1\u20092.6 years, AHI: 1.7\u2009\u00b1\u20091.2 events\/h) were recruited and matched with age, gender, and handedness. All children underwent 3.0 T magnetic resonance imaging of the brain and cognitive testing evaluating. Volumetric segmentation of cortical and subcortical structures and voxel-based morphometry were performed. Pearson's correlation analysis was performed between these features of gray matter volume (GMV) and obstructive apnea index (OAI) among children with OSA.<\/jats:p><jats:p>\n          Results\u2003In the comparison of children's Wechsler test scores of full-scale intelligence quotient and verbal intelligence quotient, the OSA group was significantly lower than the control group (p\u2009&lt;\u20090.05). Compared with the control group, the GMV of many brain regions in the OSA group was significantly decreased (p\u2009&lt;\u20090.05). In the correlation analysis of GMV and OAI in OSA group, right inferior frontal gyrus volume was significantly negatively correlated with OAI (r\u2009=\u2009\u2212\u20090.49, p\u2009=\u20090.02).<\/jats:p><jats:p>\n          Conclusion\u2003Children with OSA presented abnormal neural activities in some brain regions and impaired cognitive functions. This finding suggests an association between the OSA and decreased GMV in children.<\/jats:p>","DOI":"10.1055\/a-1993-3985","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:23Z","timestamp":1670371223000},"page":"139-146","source":"Crossref","is-referenced-by-count":6,"title":["Cognitive and Brain Gray Matter Changes in Children with Obstructive Sleep Apnea: A Voxel-Based Morphological Study"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5229-0076","authenticated-orcid":false,"given":"Li","family":"Hongbin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Guixiang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Radiology, Imaging Center, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nie","family":"Binbin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Nuclear Radiation and Nuclear Energy Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Jie","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, 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