{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:15:01Z","timestamp":1790741701332,"version":"4.1.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The upsurge of cancer demands intense, rapid and effective intervention from the\n                    scientific society. Even though nanoparticles helped achieving this, maintaining\n                    its size without using toxic capping agents is challenging. Phytochemicals\n                    having reducing properties is a proper substitute and the efficiency of such\n                    nanoparticles could be further improved by grafting with suitable monomers. It\n                    could be further protected from rapid biodegradation by coating with suitable\n                    materials. This approach was utilized wherein, the green synthesized silver\n                    nanoparticles (AgNps) were initially functionalized with \u2013COOH to couple\n                    with \u2013NH2 groups of ethylene diamine. It was then coated with\n                    polyethylene glycol (PEG) and hydrogen bonded with curcumin. The formed amide\n                    bonds could effectively uptake drug molecules and sensed environmental pH.\n                    Swelling studies and release profiles confirmed selective drug release. All\n                    these results along with those obtained from MTT assay, suggested the potential\n                    applicability of the prepared material in pH sensitive drug delivery of\n                    curcumin.<\/jats:p>","DOI":"10.1055\/a-1995-5303","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T23:38:35Z","timestamp":1677022715000},"page":"224-231","source":"Crossref","is-referenced-by-count":3,"title":["Preparation, Characterization and Evaluation of a Novel Drug Carrier\n                    for the Controlled Release of Curcumin"],"prefix":"10.1055","volume":"73","author":[{"given":"Faseela","family":"Kasim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, NSS College, Nemmara, Palakkad, Kerala,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana Somasekharan","family":"Nair","sequence":"additional","affiliation":[{"name":"LBS Institute of Technology for Women, Poojappura, Thiruvananthapuram,\n                    Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswathy","family":"Lalitha Balachandran","sequence":"additional","affiliation":[{"name":"Department of Chemistry, NSS College, Nemmara, Palakkad, Kerala,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moorikoval Parambil","family":"Sooraj","sequence":"additional","affiliation":[{"name":"AV Smaraka Govt Higher Secondary School Karivellur, Karivellur, Kerala,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop Somasekharan","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Chemistry, NSS College, Nemmara, Palakkad, Kerala,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.addr.2012.09.024","article-title":"Environment-sensitive hydrogels for drug delivery","volume":"64","author":"Q Yong","year":"2012","journal-title":"Adv. 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Toxicol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1021\/acs.biomac.9b01724","article-title":"Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into\n                    Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications","volume":"21","author":"G Abhishek","year":"2020","journal-title":"Biomacromolecules"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10965-021-02870-x","article-title":"Nanomaterials for application in wound Healing: current state-of-the-art and\n                    future perspectives","volume":"29","author":"A.S Manal","year":"2022","journal-title":"J. Polym. Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7399","DOI":"10.2147\/IJN.S213499","article-title":"Effects of functionalized silver nanoparticles on aggregation of human blood\n                    platelets","volume":"14","author":"J Hajtuch","year":"2019","journal-title":"Int. J. 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