{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:33:19Z","timestamp":1788838399854,"version":"build-2803163510"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background Some studies show that some Dibenzo derivatives can produce changes in the cardiovascular system; however, its molecular mechanism is not very clear.<\/jats:p><jats:p>Objective The objective of this investigation was to evaluate the inotropic activity of ten Dibenzo derivatives (compounds 1 to 10) on either perfusion pressure or left ventricular pressure.<\/jats:p><jats:p>Methods Biological activity produced by the Dibenzo derivatives on either perfusion pressure or coronary resistance was evaluated using an isolated rat heart. In addition, the molecular mechanism of biological activity produced by compound 4 (Dibenzo[b,e]thiophene-11(6H)-one) on left ventricular pressure was determined using both Bay-k8644 and nifedipine as pharmacological tools in an isolated rat heart model.<\/jats:p><jats:p>Results The results showed that Dibenzo[b,e]thiophene-11(6H)-one increases perfusion pressure and coronary resistance at a dose of 0.001\u2009nM. Besides, other data display that Dibenzo[b,e]thiophene-11(6H)-one increases left ventricular pressure in a dose-dependent manner (0.001 to 100\u2009nM) and this effect was similar to biological activity produced by Bay-k8644 drug on left ventricular pressure. However, the effect exerted by Dibenzo[b,e]thiophene-11(6H)-one was inhibited in the presence of nifedipine at a dose of 1\u2009nM.<\/jats:p><jats:p>Conclusions All these data suggest that Dibenzo[b,e]thiophene-11(6H)-one increase left ventricular pressure through calcium channel activation. In this way, Dibenzo[b,e]thiophene-11(6H)-one could be a good candidate as positive inotropic agent to heart failure.<\/jats:p>","DOI":"10.1055\/a-1995-6351","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:04:59Z","timestamp":1677715499000},"page":"263-270","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of Biological Activity Exerted by Dibenzo[b,e]Thiophene-11(6H)-One on Left Ventricular Pressure Using an Isolated Rat Heart Model"],"prefix":"10.1055","volume":"73","author":[{"given":"Lauro","family":"Figueroa-Valverde","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Campeche, Camp., M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Rosas-Nexticapa","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Veracruzana, M\u00e9dicos y Odontologos, Unidad del Bosque Xalapa Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Alvarez-Ramirez","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Veracruzana, M\u00e9dicos y Odontologos, Unidad del Bosque Xalapa Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"L\u00f3pez-Ramos","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Campeche, Camp., M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"D\u00edaz-Cedillo","sequence":"additional","affiliation":[{"name":"Escuela Nacional de Ciencias Biol\u00f3gicas del Instituto Polit\u00e9cnico Nacional. Santo Tomas, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Virginia","family":"Mateu-Armad","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Veracruzana, M\u00e9dicos y Odontologos, Unidad del Bosque Xalapa Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/agm2.12215","article-title":"Chinese Expert Consensus on the Diagnosis and Treatment of Chronic Heart Failure in Elderly Patients","volume":"5","author":"X Wang","year":"2022","journal-title":"Aging Med"},{"key":"ref2","first-page":"1","article-title":"Pharmacological treatment of type 2 diabetes in elderly patients with heart failure: randomized trials and beyond","volume":"1","author":"A Sciacqua","year":"2021","journal-title":"Heart Fail Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1016\/j.clnu.2021.01.014","article-title":"Prevalence and prognostic implications of malnutrition as defined by GLIM criteria in elderly patients with heart failure","volume":"40","author":"S Hirose","year":"2021","journal-title":"Clin Nut"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1007\/s00392-020-01774-y","article-title":"Energy intake during hospital stay predicts all-cause mortality after discharge independently of nutritional status in elderly heart failure patients","volume":"110","author":"S Katano","year":"2021","journal-title":"Clin Res Cardiol"},{"key":"ref5","first-page":"1133","article-title":"Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury","volume":"94","author":"C Collard","year":"2001","journal-title":"J Ame Soc Anesth"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"D Yellon","year":"2007","journal-title":"New Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/01.CIR.97.23.2302","article-title":"Angiographic assessment of myocardial reperfusion in patients treated with primary angioplasty for acute myocardial infarction: myocardial blush grade","volume":"97","author":"A Van't Hof","year":"1998","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1161\/01.CIR.0000016602.96363.36","article-title":"Fundamentals of reperfusion injury for the clinical cardiologist","volume":"105","author":"S Verma","year":"2002","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1161\/CIRCULATIONAHA.113.003046","article-title":"Nesiritide, renal function, and associated outcomes during hospitalization for acute decompensated heart failure: results from the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure","volume":"130","author":"V Van-Deursen","year":"2014","journal-title":"Circulation"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.cardfail.2021.05.007","article-title":"Captopril Versus Hydralazine-Isosorbide Dinitrate Vasodilator Protocols in Patients With Acute Decompensated Heart Failure Transitioning From Sodium Nitroprusside","volume":"27","author":"M Amar","year":"2021","journal-title":"J Cardiac Fail"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1111\/bcp.14568","article-title":"Impact of spironolactone exposure on prostate cancer incidence amongst men with heart failure: A Pharmacoepidemiological study. 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