{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:55:40Z","timestamp":1781196940795,"version":"3.54.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Research Question What are the growth patterns of uterine myomas in untreated premenopausal women? Which factors influence the growth rate of uterine myomas in premenopausal\n          women?<\/jats:p>\n                  <jats:p>Method All premenopausal women who presented to the outpatient myoma consultation clinic between January 2005 and March 2022 at least twice were screened. Exclusion criteria were\n          hormonal therapy, pregnancy, and postmenopausal status.<\/jats:p>\n                  <jats:p>Results A total of 189 patients were included in our study which focused on the respective largest uterine myoma of each woman. An ideal linear growth over time was assumed. Most\n          myomas (82%) increased in size. The mean annual growth of these myomas was 68.42\u2009cm3. The most important prognostic factor for growth was the initial size of the myoma. The\n          absolute annual growth of myomas measuring &gt;\u200950\u2009cm3 at first presentation was higher compared to smaller myomas (p\u2009&lt;\u20090.001). The relative annual growth rate was highest for\n          myomas measuring between 20 and 50\u2009cm3 at the initial presentation (p\u2009=\u20090.003). The relative annual growth rate in women older than 40 years was significantly lower than that in\n          women below the age of 40 years (p\u2009=\u20090.003).<\/jats:p>\n                  <jats:p>Conclusion Overall, it is difficult to make an individual prognosis about the growth pattern of a uterine myoma in a specific patient. It should be noted especially in asymptomatic\n          patients that spontaneous regression of myoma size can also occur in premenopausal women.<\/jats:p>","DOI":"10.1055\/a-1996-2980","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T18:33:34Z","timestamp":1680719614000},"page":"446-452","source":"Crossref","is-referenced-by-count":1,"title":["Sonographic Monitoring of Growth of Uterine Myomas in Untreated Women and Respective Influence Factors"],"prefix":"10.1055","volume":"83","author":[{"given":"Vera","family":"Seidel","sequence":"additional","affiliation":[{"name":"Obstetrics, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Klinik f\u00fcr Gyn\u00e4kologie, Charit\u00e9 Campus Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Dieter","family":"Wernecke","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biometrie und Klinische Epidemiologie, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"SOSTANA GmbH, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia Lukrezia","family":"Bellingkrodt","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie, Charit\u00e9 Campus Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Armbrust","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie, Charit\u00e9 Campus Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"David","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie, Charit\u00e9 Campus Virchow-Klinikum, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejogrb.2010.05.012","article-title":"The burden of uterine fibroids in five European countries","volume":"152","author":"E Downes","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1055\/s-2006-924359","article-title":"Pr\u00e4therapeutische \u00c4ngste, Erwartungen, W\u00fcnsche und Informiertheit von Frauen mit Uterus myomatosus","volume":"66","author":"I Utz-Billing","year":"2006","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/humupd\/dmt058","article-title":"Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, 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