{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:34:37Z","timestamp":1767832477208,"version":"3.49.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["KA 4356\/3-1"],"award-info":[{"award-number":["KA 4356\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["KR 5204\/1-2"],"award-info":[{"award-number":["KR 5204\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bayerisches Landesamt f\u00fcr Gesundheit und Lebensmittelsicherheit","award":["K1-2490-PF-2020-FBW"],"award-info":[{"award-number":["K1-2490-PF-2020-FBW"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Einleitung Ziel der Studie war die Analyse des diagnostischen Workflows von Patienten mit alveol\u00e4rer Echinokokkose (AE) und die Identifikation m\u00f6glicher diagnoseverz\u00f6gernder Faktoren.<\/jats:p><jats:p>\n          Methoden Untersucht wurden die Anzahl und Art der diagnostischen Prozeduren von Patienten mit der Diagnose einer alveol\u00e4ren Echinokokkose. Die Erfassung der Krankheitsvorgeschichte erfolgte auf Fragebogen-Basis, den vorliegenden Befunden sowie Datenerg\u00e4nzungen aus dem Patienteninformationssystem (SAP). Die statistischen Analysen wurden mit der SAS-Version 9.4 und der Microsoft-Excel Version-16.43 durchgef\u00fchrt. Das Studienkollektiv der Querschnittstudie umfasste n = 109 Patienten mit einer best\u00e4tigten alveol\u00e4ren Echinokokkose.<\/jats:p><jats:p>\n          Ergebnisse Die definitive Diagnose \u201aalveol\u00e4re Echinokokkose der Leber\u2018 wurde nach 26,5 \u00b1 65,0 (Mittelwert \u00b1 Standardabweichung) Monaten (min \u2013 max: 0\u2013344, Median = 3) gestellt. Die Mehrzahl der Patienten wurde wegen eines bildgebenden Zufallsbefundes der Leber diagnostisch abgekl\u00e4rt (n = 74\/109 (67,9%). Insgesamt n = 56\/74 (75,7%) aller Zufallsbefunde wurden ambulant, in n = 15\/74 (20,3%) der F\u00e4lle im Rahmen eines station\u00e4ren Krankenhausaufenthaltes diagnostiziert. Im Mittel wurde f\u00fcr jeden Patienten 1,1 \u00b1 1,2 (0\u201311, Median = 1) ionisierende Bildgebungsverfahren eingesetzt. Eine kontrastmittelgest\u00fctzte Sonografie erhielten 0,3 \u00b1 0,5 (0\u20132, Median = 0) Patienten. Fast alle Patienten (n = 104\/109 (95,4%) wurden zeitweise mit mindestens einer malignen hepatischen oder extrahepatischen Verdachtsdiagnose konfrontiert. Ein Ausschluss des Malignomverdachts erfolgte im Mittel nach 4,1 \u00b1 16,5 Monaten (0 \u2013133,8, Median = 1).<\/jats:p><jats:p>\n          Diskussion Der diagnostische Abkl\u00e4rungsprozess von AE-Patienten ist langwierig und belastend. Die psychische Belastung bei fraglicher maligner Diagnose ist erheblich. Der fr\u00fche Einsatz einer kontrastverst\u00e4rkten Sonografie und gegebenenfalls die Punktion unklarer hepatischer Raumforderungen hilft, den schwierigen Diagnoseprozess zu verk\u00fcrzen.<\/jats:p>","DOI":"10.1055\/a-1996-3603","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T23:55:00Z","timestamp":1674518100000},"page":"e37-e43","source":"Crossref","is-referenced-by-count":6,"title":["Diagnoseverz\u00f6gernde Faktoren bei hepatischer alveol\u00e4rer Echinokokkose"],"prefix":"10.1055","volume":"148","author":[{"given":"Natalie","family":"Joos","sequence":"first","affiliation":[{"name":"Zentraler Ultraschall, Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Ulm,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Schmidberger","sequence":"first","affiliation":[{"name":"Zentraler Ultraschall, Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Ulm,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Schlingeloff","sequence":"additional","affiliation":[{"name":"Zentraler Ultraschall, Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Ulm,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Kratzer","sequence":"additional","affiliation":[{"name":"Zentraler Ultraschall, Klinik f\u00fcr Innere Medizin I, Universit\u00e4tsklinikum Ulm,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.25646\/6307","article-title":"Alveol\u00e4re Echinokokkose: Eine Herausforderung f\u00fcr Diagnostik, Therapie und Klinisches Management","volume":"41","author":"W Kratzer","year":"2019","journal-title":"Epid Bull"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s15010-019-01325-2","article-title":"Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century","volume":"47","author":"S Baumann","year":"2019","journal-title":"Infection"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s15010-017-1094-0.","article-title":"Alveolar echinococcosis in Germany, 1992\u20132016. 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