{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:36:38Z","timestamp":1702341398819},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Wir berichten \u00fcber einen 24-j\u00e4hrigen Patienten, der sich mit anhaltenden Oberbauchschmerzen, \u00dcbelkeit und V\u00f6llegef\u00fchl ohne Erbrechen seit 5 Monaten zur ambulanten endoskopischen Diagnostik vorstellte. Bei der k\u00f6rperlichen Untersuchung fiel eine Verh\u00e4rtung im Epigastrium ohne Druckschmerzhaftigkeit auf. Endoskopisch zeigte sich lediglich eine Impression des Bulbus duodeni bei intakter Duodenalschleimhaut. Dar\u00fcber hinaus lagen unauff\u00e4llige Befunde in Gastroskopie und Ileokoloskopie vor. Abdomensonografisch zeigte sich im linken Leberlappen eine gro\u00dfe inhomogene Raumforderung mit scharfer, unregelm\u00e4\u00dfiger Begrenzung. Der rechte Leberlappen wies eine komplett unauff\u00e4llige Sonomorphologie auf, insbesondere keine Zeichen des Parenchymschadens oder einer Leberzirrhose. Entlang der oberen mesenterialen Gef\u00e4\u00dfe stellten sich mehrere vergr\u00f6\u00dferte Lymphknoten mit Kontakt zum Bulbus duodeni dar. In der Kontrastmittelsonografie (CE-US) zeigte die Leberl\u00e4sion das typische Perfusionsmuster eines hepatozellul\u00e4ren Karzinoms. Zur Kl\u00e4rung des malignit\u00e4tsverd\u00e4chtigen Befunds wurde eine sonografisch gesteuerte Stanzbiopsie durchgef\u00fchrt. Die histopathologische Aufarbeitung ergab den Befund eines hepatozellul\u00e4ren Karzinoms vom fibrolamell\u00e4ren Subtyp.<\/jats:p><jats:p>Mit diesem Fallbericht m\u00f6chten wir zeigen, dass das HCC vom fibrolamell\u00e4ren Subtyp, trotz einer starken kollagenreichen bindegewebigen Stromakomponente in der Histopathologie, ein HCC-typisches Perfusionsmuster in der KM-Sonografie aufweist.<\/jats:p>","DOI":"10.1055\/a-2000-5778","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T05:12:48Z","timestamp":1686633168000},"page":"1618-1622","source":"Crossref","is-referenced-by-count":0,"title":["Kontrastmittelsonografie eines fibrolamell\u00e4ren hepatozellul\u00e4ren Karzinoms"],"prefix":"10.1055","volume":"61","author":[{"given":"Dane","family":"Wildner","sequence":"additional","affiliation":[{"name":"Innere Medizin, Krankenh\u00e4user N\u00fcrnberger Land, Standort Lauf, Lauf an der Pegnitz, 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