{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T05:10:56Z","timestamp":1755839456644,"version":"3.37.3"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"S 01","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Clinical practice guidelines (CPG) worldwide help steer the management of early-onset neonatal sepsis (EONS). These documents typically discourage the use of risk assessment tools. However, prior work has shown that the Kaiser Permanente calculator (Early-Onset Sepsis Calculator [EOScalc]) could be a useful tool in EONS risk assessment. This study aimed to determine the agreement between the recommendations of the Colombian EONS CPG and those of the EOSCalc tool in a cohort of newborns in Bogot\u00e1, Colombia.<\/jats:p><jats:p>\n            Study Design\u2003Multicenter retrospective observational cohort study. We included newborns with a gestational age \u2265 34 weeks who were admitted to the neonatal care unit with a suspected diagnosis of EONS between 2017 and 2019. Agreement between the two tools was examined using Cohen's kappa under two scenarios (unequivocal and cautious).<\/jats:p><jats:p>\n            Results\u2003Of the 23.490 live births, 470 (1.71%) were admitted to the neonatal care unit with a presumptive diagnosis of EONS. This diagnosis was confirmed in seven patients by means of blood cultures, with group B streptococcus the most common organism (57%; 95% confidence interval [CI]: 18.4\u201390.1). A single death occurred among the patients with confirmed EONS (lethality: 14.3%). The overall incidence of EONS was 0.298 per 1,000 live births. After splitting the recommendations into two scenarios regarding antibiotic use, unequivocal and cautious, the agreement between EOSCalc and the CPG was below 15% (6 and 14%, respectively).<\/jats:p><jats:p>\n            Conclusion\u2003Recommendations from the Colombian EONS CPG show poor agreement with the EOSCalc, with the latter detecting all newborns with EONS. Although the use of EOSCalc is clinically and administratively advantageous, further prospective studies are warranted to determine the safety of its implementation.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2001-9012","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:30:21Z","timestamp":1671582621000},"page":"e1197-e1204","source":"Crossref","is-referenced-by-count":2,"special_numbering":"S","title":["Agreement between an Early-Onset Neonatal Sepsis Risk Calculator and the Colombian Clinical Practice Guideline in Three Tertiary-Care Centers in Bogot\u00e1, Colombia"],"prefix":"10.1055","volume":"41","author":[{"given":"Laura Milena","family":"Quintero-Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Facultad de medicina, Especializaci\u00f3n en pediatr\u00eda, Fundaci\u00f3n Universitaria Sanitas. Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra Alejandra","family":"Quintero-Palacios","sequence":"additional","affiliation":[{"name":"Facultad de medicina, Especializaci\u00f3n en pediatr\u00eda, Fundaci\u00f3n Universitaria Sanitas. Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-0285","authenticated-orcid":false,"given":"Mar\u00eda Alejandra","family":"Palacios-Ariza","sequence":"additional","affiliation":[{"name":"Unidad de investigaci\u00f3n, Fundaci\u00f3n Universitaria Sanitas, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mar\u00eda","family":"Morales-V\u00e9lez","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Universidad del Rosario, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina Mar\u00eda","family":"M\u00e9ndez-Vargas","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences, Universidad del Rosario, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Beltr\u00e1n-Higuera","sequence":"additional","affiliation":[{"name":"Departamento de Infectolog\u00eda Pedi\u00e1trica, Cl\u00ednica pedi\u00e1trica; Cl\u00ednica Colsanitas, Grupo Keralty, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie Ivonne","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Unidad neonatal, Cl\u00ednica Universitaria Colombia; Cl\u00ednica Colsanitas, Grupo Keralty, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reynaldo","family":"Prieto-Jure","sequence":"additional","affiliation":[{"name":"Neonatal Care Unit, Hospital Universitario Mayor \u201cMederi,\u201d Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1159\/000518059","article-title":"Comparison of NICE Guideline CG149 and the Sepsis Risk Calculator for the management of early-onset sepsis on the postnatal ward","volume":"118","author":"J A Kimpton","year":"2021","journal-title":"Neonatology"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pcl.2018.12.003","article-title":"Evaluating newborns at risk for early-onset sepsis","volume":"66","author":"P I Good","year":"2019","journal-title":"Pediatr Clin North Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jpeds.2019.05.072","article-title":"The holy grail of ascertainment of early-onset neonatal sepsis","volume":"213","author":"W E Benitz","year":"2019","journal-title":"J 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