{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T23:55:52Z","timestamp":1711324552849},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to evaluate the bone-optimal pediatric levels of\n                    25-hydroxy-vitamin D (25OHD) by testing the level at which 25OHD optimally\n                    effects calcium, phosphorus, and parathyroid hormone levels in a large\n                    population-based dataset. This was an observational retrospective\n                    \u201cbig-data\u201d study. We analyzed 49 935 25OHD tests from children\n                    sampled in Clalit Health Services, Jerusalem district between 2009 and 2019.\n                    Associated data were available in the following number of samples: corrected\n                    calcium; 18 869, phosphorus: 1241, and PTH: 449. We tested correlations between\n                    each parameter and 25OHD, adjusting phosphorus levels by age using a\n                    \u201cphosphorus index\u201d. Pearson\u2019s and Spearman\u2019s\n                    correlation coefficients were calculated to determine the strength of the\n                    correlation between 25OHD and each parameter. There was a significant\n                    correlation between 25OHD levels and both PTH and calcium but not for the\n                    phosphorus index. The level at which increase in 25OHD continued to cause\n                    significant alteration was: for PTH up to 100 nmol\/l\n                    (40\u2009ng\/ml), for corrected calcium it increased beyond 100\n                    nmol\/l. Increasing levels of 25OHD levels up to at least 100\n                    nmol\/l are associated with improvement in parameters known to be\n                    associated with increased bone mineralization. Therefore, one should aim for a\n                    25OHD level of 100 nmo\/l.<\/jats:p>","DOI":"10.1055\/a-2003-0124","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:25Z","timestamp":1671667225000},"page":"191-195","source":"Crossref","is-referenced-by-count":1,"title":["Optimal 25-OH-Vitamin D Level in Children Derived From Biochemical\n                    Parameters"],"prefix":"10.1055","volume":"55","author":[{"given":"David","family":"Gillis","sequence":"additional","affiliation":[{"name":"Pediatrics, Hebrew University-Hadassah Medical Center, Jerusalem,\n                    Israel"},{"name":"Faculty of Medicine, Hebrew University, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"Hefter","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hebrew University, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalom","family":"Edri","sequence":"additional","affiliation":[{"name":"Department of Data Management, Clalit Health Services, Jerusalem,\n                    Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Strich","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hebrew University, Jerusalem, Israel"},{"name":"Department of Pediatrics, Shaare Zedek Medical Center, Jerusalem,\n                    Israel"},{"name":"Pediatric Specialties Clinics, Clalit Health Services, Jerusalem,\n                    Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jsbmb.2017.01.021","article-title":"Vitamin D supplementation guidelines","volume":"175","author":"P Pludowski","year":"2018","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3345\/kjp.2016.59.7.292","article-title":"Increment in vitamin D level and bone mineral accrual in children with vitamin D\n                    deficiency","volume":"59","author":"Y K Rao","year":"2016","journal-title":"Korean J Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bone.2004.02.003","article-title":"The relationship between vitamin D and parathyroid hormone: calcium homeostasis,\n                    bone turnover, and bone mineral density in postmenopausal women with established\n                    osteoporosis","volume":"35","author":"O Sahota","year":"2004","journal-title":"Bone"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1210\/jc.2015-1643","article-title":"Effect of vitamin D3 supplementation in black and in white children: a\n                    randomized, placebo-controlled trial","volume":"100","author":"K Rajakumar","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00198-014-2877-0","article-title":"Associations between serum 25-hydroxyvitamin D and bone mineral density and\n                    proximal femur geometry in Koreans: the Korean National Health and Nutrition\n                    Examination Survey (KNHANES) 2008\u20132009","volume":"26","author":"S Hwang","year":"2015","journal-title":"Osteoporos Int"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.amjmed.2003.12.029","article-title":"Vitamin D levels and bone mineral density: a population-based study of younger\n                    and older adults","volume":"116","author":"H A Bischoff-Ferrari","year":"2004","journal-title":"Am J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1359\/jbmr.090728","article-title":"Bone mineralization defects and vitamin D deficiency: histomorphometric analysis\n                    of iliac crest bone biopsies and circulating 25-Hydroxyvitamin D in 675\n                    patients","volume":"25","author":"M Priemel","year":"2010","journal-title":"J Bone Miner Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"M F Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1080\/10408363.2017.1379945","article-title":"The Canadian laboratory initiative on pediatric reference intervals: A CALIPER\n                    white paper","volume":"54","author":"K Adeli","year":"2017","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3345\/kjp.2017.60.2.45","article-title":"The serum level of 25-hydroxyvitamin D for maximal suppression of parathyroid\n                    hormone in children: the relationship between 25- hydroxyvitamin D and\n                    parathyroid hormone","volume":"60","author":"J I Kang","year":"2017","journal-title":"Korean J Pediatr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.4274\/jcrpe.3301","article-title":"Prevalence of vitamin D deficiency and calcium homeostasis in saudi\n                    children","volume":"8","author":"AM A Shaikh","year":"2016","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1210\/jc.2013-2728","article-title":"A randomized trial of vitamin D3 supplementation in children: dose-response\n                    effects on vitamin D metabolites and calcium absorption","volume":"98","author":"R D Lewis","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2265.1995.tb02916.x","article-title":"Vitamin D intoxication causes hypercalcaemia by increased bone resorption which\n                    responds to pamidronate","author":"P L Selby","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13052-018-0479-8","article-title":"Vitamin D levels and parathyroid hormone variations of children living in a\n                    subtropical climate: a data mining study","volume":"44","author":"O N Sahin","year":"2018","journal-title":"Ital J Pediatr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.15537\/smj.2016.9.15248","article-title":"Vitamin D deficiency and biochemical variations among urban Saudi adolescent\n                    girls according to season","volume":"37","author":"R A Sulimani","year":"2016","journal-title":"Saudi Med J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/archdischild-2015-308985","article-title":"Dietary calcium intake influences the relationship between serum\n                    25-hydroxyvitamin D3 (25OHD) concentration and parathyroid hormone (PTH)\n                    concentration","volume":"101","author":"P Patel","year":"2016","journal-title":"Arch Dis Child"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.1210\/jc.2005-1021","article-title":"Relationships among vitamin D levels, parathyroid hormone, and calcium\n                    absorption in young adolescents","volume":"90","author":"S A Abrams","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1152\/ajprenal.00013.2004","article-title":"Role of the calcium-sensing receptor in parathyroid gland physiology. Am J\n                    Physiol","volume":"286","author":"R A Chen","year":"2004","journal-title":"Ren Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2016.00172","article-title":"Review of hypoparathyroidism","volume":"7","author":"E G Abate","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/pr.2013.139","article-title":"Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the\n                    search for a biochemical definition of vitamin D deficiency in children","volume":"74","author":"N Atapattu","year":"2013","journal-title":"Pediatr Res"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2003-0124.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T10:57:07Z","timestamp":1683284227000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2003-0124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":20,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,2,27]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2003-0124","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12,21]]},"published":{"date-parts":[[2022,12,21]]}}}