{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T19:39:27Z","timestamp":1726429167887},"reference-count":68,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund\u2002Die chronische Rhinosinusitis mit Nasenpolypen (CRSwNP) ist eine multifaktorielle entz\u00fcndliche Erkrankung der Schleimh\u00e4ute von Nase und Nasennebenh\u00f6hlen. Eine eosinophile Entz\u00fcndung wird als h\u00e4ufiger Endotyp beschrieben. Der Anti-IL-5-Antik\u00f6rper Mepolizumab ist seit November 2021 als Zusatztherapie zu intranasalen Glukokortikosteroiden f\u00fcr die Behandlung Erwachsener mit schwerer chronischer Rhinosinusitis mit Nasenpolypen zugelassen, wenn systemische Glukokortikosteroide oder eine Operation keine ausreichende Krankheitskontrolle bewirken. W\u00e4hrend nationale und internationale Empfehlungen f\u00fcr den Einsatz von Mepolizumab bei CRSwNP existieren, ist bislang nicht hinreichend festgelegt worden, wie diese Therapie \u00fcberwacht wird, welche Folgedokumentation notwendig ist und wann sie ggf. beendet werden sollte.<\/jats:p><jats:p>\n          Methoden\u2002In einer Literatursuche wurden die bisherigen Daten zur Behandlung der CRSwNP mit Mepolizumab analysiert und die vorhandene Evidenz durch Recherchen in MEDLINE, PubMed sowie den nationalen und internationalen Studien- und Leitlinienregistern und der Cochrane Library ermittelt. Es wurden Humanstudien ber\u00fccksichtigt, die im Zeitraum bis einschlie\u00dflich 10\/2022 publiziert wurden.<\/jats:p><jats:p>\n          Ergebnis\u2002Basierend auf der internationalen Literatur und bisherigen Erfahrungen werden von einem Expertengremium Empfehlungen f\u00fcr die Verlaufskontrolle, das Einhalten von Therapieintervallen und eventuelle Therapiepausen sowie eine Beendigung der Therapie bei Anwendung von Mepolizumab f\u00fcr die Indikation CRSwNP im deutschen Gesundheitssystem auf der Grundlage eines Dokumentationsbogens gegeben.<\/jats:p><jats:p>\n          Schlussfolgerungen\u2002Das Verst\u00e4ndnis \u00fcber die immunologischen Grundlagen der CRSwNP er\u00f6ffnet neue, nichtoperative Therapieans\u00e4tze mit Biologika f\u00fcr Patient*innen mit schweren, unkontrollierten Verlaufsformen. Hier geben wir Empfehlungen f\u00fcr die Verlaufskontrolle, das Einhalten von Therapieintervallen, eventuelle Therapiepausen oder eine Beendigung der Therapie bei einer Mepolizumab-Behandlung als Zusatztherapie mit intranasalen Glukokortikosteroiden zur Behandlung von erwachsenen Patient*innen mit schwerer CRSwNP, die mit systemischen Glukokortikosteroiden und\/oder chirurgischem Eingriff nicht ausreichend kontrolliert werden kann.<\/jats:p>","DOI":"10.1055\/a-2003-4730","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T23:39:01Z","timestamp":1675813141000},"page":"89-99","source":"Crossref","is-referenced-by-count":1,"title":["Empfehlungen zur \u00dcberpr\u00fcfung der Wirksamkeit und Verlaufsdokumentation von Mepolizumab bei chronischer Rhinosinusitis mit Nasenpolypen (CRSwNP) im deutschen Gesundheitssystem \u2013 Empfehlungen des \u00c4rzteverbandes Deutscher Allergologen (AeDA) und der AGs Klinische Immunologie, Allergologie und Umweltmedizin und Rhinologie und Rhinochirurgie der\u00a0Deutschen Gesellschaft f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC)"],"prefix":"10.1055","volume":"102","author":[{"given":"L.","family":"Klimek","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Rhinologie und Allergologie, Wiesbaden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"F\u00f6rster-Ruhrmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Charit\u00e9-Universit\u00e4tsmedizin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Olze","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Charit\u00e9-Universit\u00e4tsmedizin Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G.","family":"Beule","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Universit\u00e4tsklinikum M\u00fcnster"},{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie der Universit\u00e4tsmedizin Greifswald"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Chaker","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, TUM School of Medicine, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen"},{"name":"Zentrum f\u00fcr Allergie und Umwelt (ZAUM), TUM School of Medicine, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hagemann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Universit\u00e4tsmedizin Mainz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Huppertz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Universit\u00e4tsmedizin Mainz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. K.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Universit\u00e4tsklinikum Ulm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dazert","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Ruhr-Universit\u00e4t Bochum, St.-Elisabeth-Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Deitmer","sequence":"additional","affiliation":[{"name":"Deutsche Gesellschaft f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Bonn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Strieth","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsklinikum Bonn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wrede","sequence":"additional","affiliation":[{"name":"Hals-, Nasen- und Ohrenarzt, Herford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Schlenter","sequence":"additional","affiliation":[{"name":"\u00c4rzteverband Deutscher Allergologen, Wiesbaden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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Klimek","year":"2020","journal-title":"Laryngo-Rhino-Otol"},{"issue":"08","key":"ref12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1055\/a-1197-0136","article-title":"Positionspapier: Anwendung von Biologika bei chronischer Rhinosinusitis mit Polyposis nasi (CRSwNP) im deutschen Gesundheitssystem \u2013 Empfehlungen des \u00c4rzteverbandes Deutscher Allergologen (AeDA) und der AGs Klinische Immunologie, Allergologie und Umweltmedizin und Rhinologie und Rhinochirurgie der Deutschen Gesellschaft f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC)","volume":"99","author":"L Klimek","year":"2020","journal-title":"Laryngo-Rhino-Otol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1055\/a-1592-0316","article-title":"Positionspapier: Hinweise zur Patienteninformation und -aufkl\u00e4rung vor Anwendung von Biologika bei chronischer Rhinosinusitis mit Nasenpolypen (CRSwNP) \u2013 Teil 2: Omalizumab \u2013 Empfehlungen des \u00c4rzteverbandes 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