{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:37:04Z","timestamp":1764131824419,"version":"3.46.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Chronic cough is one of the most common symptoms in childhood.\n                    Making a definite diagnosis is a challenge for all pediatricians especially in\n                    patients when cough is without an organic cause like in habit cough.<\/jats:p>\n                  <jats:p>Patients and Methods In this retrospective analysis, all electronic\n                    outpatient charts of the Division of Allergology and Pneumology, between January\n                    1, 2010 and December 31, 2019 were reviewed in order to study all children with\n                    potential habit cough. All children underwent the following diagnostic\n                    algorithms, skin prick test (SPT), measurement of fractional exhaled nitric\n                    oxide (FeNO), spirometry and methacholine challenge test (MCT). The value of a\n                    normal MCT and FeNO measurement for diagnosing habit cough was investigated.<\/jats:p>\n                  <jats:p>Results The chart review revealed 482 patients with chronic\n                    cough&gt;4 weeks. Of these, 99 (20.5%) with suspected habit cough\n                    were collected. 13 patients had to be excluded for other diagnosis and a\n                    complete data set was available in 55 patients. 33 (60.0%) of 55\n                    patients were SPT negative and 22 (40.0%) had sensitization to common\n                    allergens. Five patients had elevated FeNO\u226520 ppb and three showed\n                    severe bronchial hyperresponsiveness&lt;0.1\u2009mg methacholine,\n                    challenging the diagnosis of habit cough.<\/jats:p>\n                  <jats:p>Conclusion A normal FeNO and MCT can help confirm the clinical diagnosis\n                    of habit cough. However, in patients with positive MCT and\/or elevated\n                    FeNO habit cough can be present. Especially in patients with elevated FeNO and\n                    severe BHR cough variant asthma and eosinophilic bronchitis have to be ruled\n                    out.<\/jats:p>","DOI":"10.1055\/a-2004-3477","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T18:41:23Z","timestamp":1675190483000},"page":"84-89","source":"Crossref","is-referenced-by-count":1,"title":["Methacholine and FeNO Measurement in Patients with Habit\n                    Cough"],"prefix":"10.1055","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3381-3759","authenticated-orcid":false,"given":"Sandra","family":"Woelke","sequence":"additional","affiliation":[{"name":"Department for Children and Adolescence, Division of Allergy,\n                    Pulmonology and Cystic fibrosis, University Hospital Frankfurt, Goethe\n                    University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Szelenyi","sequence":"additional","affiliation":[{"name":"Department for Children and Adolescence, Division of Allergy,\n                    Pulmonology and Cystic fibrosis, University Hospital Frankfurt, Goethe\n                    University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Dre\u00dfler","sequence":"additional","affiliation":[{"name":"Department for Children and Adolescence, Division of Allergy,\n                    Pulmonology and Cystic fibrosis, University Hospital Frankfurt, Goethe\n                    University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordis","family":"Trischler","sequence":"additional","affiliation":[{"name":"Department for Children and Adolescence, Division of Allergy,\n                    Pulmonology and Cystic fibrosis, University Hospital Frankfurt, Goethe\n                    University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Donath","sequence":"additional","affiliation":[{"name":"Department for Children and Adolescence, Division of Allergy,\n                    Pulmonology and Cystic fibrosis, University Hospital Frankfurt, Goethe\n                    University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hutter","sequence":"additional","affiliation":[{"name":"Department for Children and Adolescence, Division of Allergy,\n                    Pulmonology and Cystic fibrosis, University Hospital Frankfurt, Goethe\n                    University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Bl\u00fcmchen","sequence":"additional","affiliation":[{"name":"Department for Children and Adolescence, Division of Allergy,\n                    Pulmonology and Cystic fibrosis, University Hospital Frankfurt, Goethe\n                    University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Zielen","sequence":"additional","affiliation":[{"name":"Department for Children and Adolescence, Division of Allergy,\n                    Pulmonology and Cystic fibrosis, University Hospital Frankfurt, Goethe\n                    University, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1164\/rccm.200308-1178OC","article-title":"Sorkness Classifying asthma severity in children: mismatch between symptoms,\n                    medication use, and lung function","volume":"170","author":"L B Bacharier","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1398-9995.2011.02728.x","article-title":"Global Allergy and Asthma European Network; Allergic Rhinitis and its Impact on\n                    Asthma. 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BTS guidelines: Recommendations for\n                    the assessment and management of cough in children","author":"M D Shields","journal-title":"Thorax. 2008; 63"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00408-011-9317-0","article-title":"The habit cough syndrome and its variations","volume":"190","author":"M Weinberger","year":"2012","journal-title":"Lung"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.jaci.2015.09.002","article-title":"The cough without a cause: Habit cough syndrome","volume":"137","author":"M Weinberger","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"ref32","first-page":"22","article-title":"Lockshin","volume":"13","author":"M Weinberger","year":"2017","journal-title":"When is cough functional, and how should it be treated?\n                    Breathe"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/ppul.23979","article-title":"The habit cough: Diagnosis and treatment","volume":"53","author":"M Weinberger","year":"2018","journal-title":"Pediatr Pulmonol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ppul.23954","article-title":"Habit-tic cough: Presentation and outcome with simple reassurance","volume":"53","author":"A Zacharasiewicz","year":"2018","journal-title":"Pediatr Pulmonol"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2004-3477.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:28:31Z","timestamp":1764131311000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2004-3477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":33,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,3,9]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2004-3477","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"type":"print","value":"0300-8630"},{"type":"electronic","value":"1439-3824"}],"subject":[],"published":{"date-parts":[[2023,1,31]]}}}