{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:20:00Z","timestamp":1787509200912,"version":"build-2736575974"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Retrocorneal membranes (RCMs) may result from epithelial ingrowth, stromal keratocytic downgrowth, fibrous metaplasia of the corneal endothelium, or a combination of these\n          processes. In an institutional case series, the clinical history, ocular findings, and immunohistochemical staining results of RCMs were analysed in patients with unilateral corneal\n          decompensation after complicated intraocular surgery.<\/jats:p>\n                  <jats:p>Methods and Patients Between January 2021 and September 2022, six retrocorneal membranes were excised during Descemet\u02bcs stripping automated endothelial keratoplasty (DSAEK) and\n          Descemet membrane endothelial keratoplasty (DMEK) procedures and classified after screening with haematoxylin and eosin, periodic acid-Schiff, elastic van Gieson staining, and\n          immunohistochemical screening with cytokeratin 7 (CK7), anti-cytokeratin (CAM5.2 and AE1\/3), cell surface glycoprotein CD34, smooth muscle actin (\u03b1-SMA), and vimentin.<\/jats:p>\n                  <jats:p>Results On the basis of the immunohistochemical screening, the majority of excised RCMs (5 of 6) could histopathologically be classified as membranes originating from fibrous\n          metaplasia of the corneal endothelium. All these RCMs were positive for CK7, \u03b1-SMA, and vimentin and negative for CAM5.2 and CD34. In one patient, an RCM had developed after 18 days\n          of corneal contact to a free-floating dexamethasone implant in the anterior chamber and was classified as originating from stromal keratocyte downgrowth (\u03b1-SMA- and vimentin-positive,\n          all others negative). All eyes in this series had a previous history of complicated cataract surgery, partially with subsequent intraocular lens exchange. No eyes after previous penetrating\n          keratoplasty were in this series.<\/jats:p>\n                  <jats:p>Conclusions In this series of eyes with previous complicated intraocular interventions (in most cases cataract surgery and revisions), the dominating RCM belonged to the type\n          originating from fibrous metaplasia of the corneal endothelium.<\/jats:p>","DOI":"10.1055\/a-2013-2770","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T18:42:48Z","timestamp":1682448168000},"page":"402-407","source":"Crossref","is-referenced-by-count":2,"title":["Immunohistochemical Findings in Retrocorneal Membranes of Eyes with Corneal Decompensation after Complicated Intraocular Surgery"],"prefix":"10.1055","volume":"240","author":[{"given":"Heinrich","family":"Gerding","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Pallas Kliniken AG, Olten, Switzerland"},{"name":"Department of Ophthalmology, University of M\u00fcnster, Munster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Schlageter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Viollier AG, Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zettl","sequence":"additional","affiliation":[{"name":"Department of Pathology, Viollier AG, Allschwil, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Goldblum","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Pallas Kliniken AG, Olten, Switzerland"},{"name":"Department of Ophthalmology, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Tappeiner","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Pallas Kliniken AG, Olten, Switzerland"},{"name":"Department of Ophthalmology, University Hospital Essen, University Duisburg-Essen, Essen, Germany"},{"name":"Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy"},{"name":"Medical Faculty, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/bjo.51.6.379","article-title":"Retrocorneal membranes. I. Their origin and structure","volume":"51","author":"E S Sherrard","year":"1967","journal-title":"Br J Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/bjo.51.6.387","article-title":"Retrocorneal membranes. II. Factors influencing their growth","volume":"51","author":"E S Sherrard","year":"1967","journal-title":"Br J Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0896-1549(01)00013-X","article-title":"Epithelial and fibrous downgrowth: mechanisms of disease","volume":"15","author":"S H Chen","year":"2002","journal-title":"Ophthalmol Clin North Am"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1097\/ICO.0b013e31812f6f1b","article-title":"Corneal wound healing from the perspective of keratoplasty specimens with special refernence to the function of the Bowman layer and Descemet membrane","volume":"26","author":"H Obata","year":"2007","journal-title":"Cornea"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3346\/jkms.2014.29.6.846","article-title":"Evaluation of stem cell components in retrocorneal membranes","volume":"29","author":"S H Lee","year":"2014","journal-title":"J Korean Med Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0002-9394(14)74450-2","article-title":"Retrocorneal fibrous membranes in failed corneal grafts","volume":"115","author":"I Kremer","year":"1993","journal-title":"Am J Ophthalmol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1055\/s-0029-1245481","article-title":"Histopathologische Untersuchungen von retrokornealen Membranen bei irreversiblem Transplantatversagen","volume":"227","author":"S Calabrese","year":"2010","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ajo.2010.03.011","article-title":"Retrocorneal membranes: a comparative immunohistological analysis of keratocytic, endothelial, and epithelial origins","volume":"150","author":"F A Jakobiec","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"ref9","first-page":"15","article-title":"Extracellular matrix components in retrcorneal fibrous membrane in comparison to corneal endothelium and Descement\u02bcs membrane","volume":"6","author":"E W Leung","year":"2000","journal-title":"Mol Vis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00003226-200211000-00012","article-title":"An immunohistochemical analysis and comparison of posterior polymorphous dystrophy with congenital hereditary endothelial dystrophy","volume":"21","author":"G C Cockerham","year":"2002","journal-title":"Cornea"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1097\/01.ico.0000228786.84581.ee","article-title":"Epithelial metaplasia of the corneal endothelium in Fuchs endothelial Dystrophy","volume":"25","author":"A Hidayat","year":"2006","journal-title":"Cornea"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1074\/jbc.RA117.000295","article-title":"Fibroblast growth factor 2 induces proliferation and fibrosis via SNAI1-mediated activation of CDK2 and ZEB1 in corneal endothelium","volume":"293","author":"J G Lee","year":"2018","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.exer.2017.10.006","article-title":"The role of hepatocyte growth factor in corneal wound healing","volume":"166","author":"H Miyagi","year":"2018","journal-title":"Exp Eye Res"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2013-2770.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T18:43:40Z","timestamp":1682448220000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2013-2770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":13,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,4,25]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2013-2770","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]}}}