{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:14:45Z","timestamp":1790273685708,"version":"4.1.0"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"Key laboratory project of colleges and universities in Guangdong province","award":["2019KSYS005"],"award-info":[{"award-number":["2019KSYS005"]}]},{"name":"science and technology program of Guangzhou","award":["202201011195"],"award-info":[{"award-number":["202201011195"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21904110"],"award-info":[{"award-number":["21904110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81973918"],"award-info":[{"award-number":["81973918"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong province science and technology plan international cooperation project","award":["2020A0505100052"],"award-info":[{"award-number":["2020A0505100052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer\u02bcs disease (AD) is a critical neurodegenerative disease that manifests as progressive intellectual decline and is pathologically characterized by a progressive loss of neurons in the brain. Despite extensive research on this topic, the pathogenesis of AD is not fully understood, while the beta-amyloid (A\u03b2) hypothesis remains the dominant one and only a few symptomatic drugs are approved for the treatment of AD. Ginseng has been widely reported as an effective herbal medicine for the treatment of neurodegenerative diseases such as dementia. Therefore, we explore the protective effects of ginseng in AD by a network pharmacological approach based on the pathogenesis of A\u03b2. Twenty-one major ginsenosides are screened based on ultraperformance liquid chromatography-mass spectrometry\/mass spectrometry (HPLC-MS\/MS) data. Among them, MAPK8, MAPK9, BACE1, FLT1, CDK2, and CCR5 are the core targets. By molecular docking and validation with the in vitro cell model APPswe-SH-SY5Y, we find that ginsenosides Rg3 and Ro have good neuroprotective effects and can reduce the expression of A\u03b2 1\u200a\u2013\u200a42 in APPswe-SH-SY5Y. Finally, through RT-qPCR experiment, we find that ginsenoside Rg3 targeted MAPK8, FLT1, and CCR5, while ginsenoside Ro targeted MAPK8, MAPK9, FLT1, and CCR5 for its potential anti-AD efficacy.<\/jats:p>","DOI":"10.1055\/a-2014-6061","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T03:41:44Z","timestamp":1674013304000},"page":"990-1000","source":"Crossref","is-referenced-by-count":12,"title":["Network Pharmacology and Mechanism Studies of the Protective Effect of Ginseng against Alzheimer\u02bcs Disease Based on A\u03b2 Pathogenesis"],"prefix":"10.1055","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6421-7482","authenticated-orcid":false,"given":"Jinman","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Jiangmen TCM Hospital of Ji\u02bcnan University, Jiangmen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Yu","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiru","family":"Ma","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyao","family":"Li","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liang","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Su","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangcheng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouyuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer\u02bcs disease","volume":"430","author":"M P Mattson","year":"2004","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S1474-4422(15)00302-6","article-title":"Long-term effects of Alzheimer\u02bcs disease treatment","volume":"14","author":"A Wimo","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"a023705","DOI":"10.1101\/cshperspect.a023705","article-title":"Molecular 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