{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:27:40Z","timestamp":1780612060519,"version":"3.54.1"},"reference-count":70,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/100006812","name":"Center for Integrated Healthcare, U.S. Department of Veterans Affairs","doi-asserted-by":"crossref","award":["IK6BX005226, 1I01BX003031"],"award-info":[{"award-number":["IK6BX005226, 1I01BX003031"]}],"id":[{"id":"10.13039\/100006812","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AA030107, DK108959, DK119421"],"award-info":[{"award-number":["AA030107, DK108959, DK119421"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Growth hormone (GH) and downstream insulin-like growth factor 1 (IGF1) signaling mediate growth and metabolism. GH deficiency causes short stature or dwarfism, and excess GH causes acromegaly. Although the association of GH\/IGF1 signaling with liver diseases has been suggested previously, current studies are controversial and the functional roles of GH\/IGF1 signaling are still undefined. GH supplementation therapy showed promising therapeutic effects in some patients, such as non-alcoholic fatty liver disease, but inhibition of GH signaling may be beneficial for other liver diseases, such as hepatocellular carcinoma. The functional roles of GH\/IGF1 signaling and the effects of agonists\/antagonists targeting this signaling may differ depending on the liver injury or animal models. This review summarizes current controversial studies of GH\/IGF1 signaling in liver diseases and discusses therapeutic potentials of GH therapy.<\/jats:p>","DOI":"10.1055\/a-2015-1359","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T23:50:45Z","timestamp":1674085845000},"page":"024-030","source":"Crossref","is-referenced-by-count":9,"title":["Growth Hormone Signaling in Liver Diseases: Therapeutic Potentials and Controversies"],"prefix":"10.1055","volume":"43","author":[{"given":"Madisyn","family":"Oxley","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Francis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"},{"name":"Department of Research, Richard L. 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