{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T05:09:58Z","timestamp":1764133798332,"version":"3.46.0"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objectives Canine eosinophilic bronchopneumopathy (EBP) is a poorly\n                    understood disease characterized by chronic inflammation of the lower airways.\n                    To date, factors affecting the course of the disease are largely unknown. The\n                    objective of this study was to investigate the influence of clinical,\n                    laboratory, and environmental factors on therapeutic outcome in dogs with\n                    EBP.<\/jats:p>\n                  <jats:p>Material and methods Environmental and housing conditions, course of\n                    disease, and response to treatment were evaluated using a standardized\n                    questionnaire for owners of 29 dogs diagnosed with EBP from 3 different\n                    veterinary referral centers in Germany. Data of diagnostic tests (hematology,\n                    radiographs, bronchoalveolar-lavage-fluid-(BALF) cytology) were retrospectively\n                    obtained from medical records. The influence of the different factors was\n                    assessed using Fisher's-exact-test and Mann-Whitney-U- or\n                    Kruskal-Wallis-test.<\/jats:p>\n                  <jats:p>Results The proportion of neutrophilic granulocytes in BALF-cytology was\n                    significantly higher in dogs with persistent clinical signs compared to dogs\n                    that achieved clinical remission (p=0.029). Duration of clinical signs\n                    before treatment was significantly longer in dogs with persistent clinical signs\n                    (16\u00b112 months) compared to dogs that achieved clinical remission\n                    (6\u00b17 months) (p=0.017).<\/jats:p>\n                  <jats:p>Conclusion Early diagnosis and therapy have a decisive influence on the\n                    success of treatment.<\/jats:p>\n                  <jats:p>Clinical relevance Dogs with respiratory signs suspicious for EBP should\n                    be evaluated in a timely manner to increase the likelihood of clinical remission\n                    with an early start of therapy.<\/jats:p>","DOI":"10.1055\/a-2015-2590","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T19:32:17Z","timestamp":1678822337000},"page":"15-21","source":"Crossref","is-referenced-by-count":0,"title":["Factors influencing the response to therapy in dogs with eosinophilic\n                    bronchopneumopathy"],"prefix":"10.1055","volume":"51","author":[{"given":"Vanessa","family":"De Simoi","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik M\u00fcnchen,\n                    Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca D\u00e9sir\u00e9e","family":"Ballhausen","sequence":"additional","affiliation":[{"name":"AniCura Tierklinik Haar, Haar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Lena","family":"Proksch","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere \u2013 Innere Medizin, Fachbereich\n                    Veterin\u00e4rmedizin, Justus-Liebig-Universit\u00e4t\n                    Gie\u00dfen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik M\u00fcnchen,\n                    Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yury","family":"Zablotski","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik M\u00fcnchen,\n                    Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianka","family":"Schulz","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik M\u00fcnchen,\n                    Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1939-1676.2000.tb01168.x","article-title":"Eosinophilic bronchopneumopathy in dogs","volume":"14","author":"C Clercx","year":"2000","journal-title":"J Vet Intern Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1939-1676.2002.tb02362.x","article-title":"An immunologic investigation of canine eosinophilic bronchopneumopathy","volume":"16","author":"C Clercx","year":"2002","journal-title":"J Vet Intern Med"},{"key":"ref3","first-page":"1096","volume-title":"Pulmonary Parenchymal Disease. 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