{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:40:17Z","timestamp":1790959217921,"version":"4.1.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathophysiological processes of dementia and cognitive impairment are linked\n                    to advanced glycation end products (AGEs) and their receptor (RAGE).The\n                    neurofibrillary tangles (NFTs) of abnormally hyperphosphorylated tau protein and\n                    senile plaques (SPs), which are brought on by amyloid beta (A\u03b2)\n                    deposition, are the hallmarks of Alzheimer\u2019s disease (AD), a progressive\n                    neurodegenerative condition. Advanced glycation end products that are produced\n                    as a result of vascular dysfunction are bound by the receptor for advanced\n                    glycation end products (RAGE). Dementia and cognitive impairment could develop\n                    when RAGE binds to A\u03b2 and produces reactive oxygen species, aggravating\n                    A\u03b2 buildup and ultimately resulting in SPs and NFTs. RAGE could be a\n                    more powerful biomarker than A\u03b2 because it is implicated in early AD.\n                    The resident immune cells in the brain known as microglia are essential for\n                    healthy brain function. Microglia is prominent in the amyloid plaques\u2019\n                    outside border as well as their central region in Alzheimer\u2019s disease.\n                    Microglial cells, in the opinion of some authors, actively contribute to the\n                    formation of amyloid plaques. In this review, we first discuss the early\n                    diagnosis of dementia and cognitive impairment, and then detail the interaction\n                    between RAGE and A\u03b2 and Tau that is necessary to cause dementia and\n                    cognitive impairment pathology, and it is anticipated that the creation of RAGE\n                    probes will help in the diagnosis and treatment of dementia and cognitive\n                    impairment.<\/jats:p>","DOI":"10.1055\/a-2015-8041","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T23:54:15Z","timestamp":1678319655000},"page":"247-250","source":"Crossref","is-referenced-by-count":23,"title":["Receptor for Advanced Glycation End Products: Dementia and Cognitive\n                    Impairment"],"prefix":"10.1055","volume":"73","author":[{"given":"Aditya","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Integral University,\n                    Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaseem Ahamad","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Integral University,\n                    Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarique","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Integral University,\n                    Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farogh","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Integral University,\n                    Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rufaida","family":"Wasim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Integral University,\n                    Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shariq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Integral University,\n                    Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Parveen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Pharmacy, Integral University,\n                    Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhrat","family":"Maheshwari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Rama\n                    University, Mandhana, Bithoor Road, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1474-4422(05)70284-2","article-title":"\ufeffStaekenborg S\ufeff, Brunner E\ufeff, Brayne C\ufeff, Scheltens P\ufeff. 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