{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T19:27:30Z","timestamp":1769974050050,"version":"3.49.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infantile myofibromatosis is a rare benign congenital tumour that often regresses\n                    spontaneously but may pose therapeutic challenges in its widespread visceral\n                    form. We present the case of a full-term neonate with generalized infantile\n                    myofibromatosis including ubiquitous subcutaneous and muscular nodules, a tumour\n                    in the mastoid and disseminated intestinal involvement. The intestinal tumours\n                    led to a mechanical ileus with intestinal perforation within the first days of\n                    life. After partial small bowel resection and necessary proximal jejunostomy the\n                    boy was dependent on total parenteral nutrition. Chemotherapy with vinblastine\n                    and methotrexate was started and was temporarily supplemented with imatinib.\n                    Feeding stayed impossible despite tumour shrinkage. At the age of 4.5 months,\n                    restoration of intestinal continuity with further stricturoplasties was\n                    performed which \u2013 for the first time \u2013 allowed complete oral\n                    feeding. Chemotherapy was continued for further two months. Currently, the child\n                    is in good general condition with growth and further disease regression. This\n                    report suggests that massive visceral involvement of infantile myofibromatosis\n                    may require extensive intestinal surgery, as conservative therapy cannot resolve\n                    the disease and its sequelae.<\/jats:p>","DOI":"10.1055\/a-2018-5454","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T19:46:02Z","timestamp":1678909562000},"page":"231-235","source":"Crossref","is-referenced-by-count":1,"title":["Generalized Infantile Myofibromatosis with Extensive Small Bowel\n                    Involvement in a Neonate"],"prefix":"10.1055","volume":"227","author":[{"given":"Judit Pauline","family":"Schubert","sequence":"additional","affiliation":[{"name":"Pediatric Surgery, AKK Altonaer Kinderkrankenhaus gGmbH, Hamburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"W\u00f6\u00dfmann","sequence":"additional","affiliation":[{"name":"Pediatric Haematology and Oncology, University Medical Center\n                    Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"K\u00f6nigs","sequence":"additional","affiliation":[{"name":"Pediatric Surgery, AKK Altonaer Kinderkrankenhaus gGmbH, Hamburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Clauditz","sequence":"additional","affiliation":[{"name":"Pathology, University Medical Center Hamburg-Eppendorf, Hamburg,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Kordes","sequence":"additional","affiliation":[{"name":"Pediatric Haematology and Oncology, University Medical Center\n                    Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Reinshagen","sequence":"additional","affiliation":[{"name":"Pediatric Surgery, University Medical Center Hamburg-Eppendorf,\n                    Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1093\/hmg\/ddx081","article-title":"PDGFRB gain-of-function mutations in sporadic infantile myofibromatosis","volume":"26","author":"A Florence","year":"2017","journal-title":"Hum Mol Genet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/onc.2015.383","article-title":"PDGFRB mutants found in patients with familial infantile myofibromatosis or\n                    overgrowth syndrome are oncogenic and sensitive to imatinib","author":"F A Art","year":"2015","journal-title":"Oncogene"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1001\/jamadermatol.2019.0114","article-title":"Fraitag S et. 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Treatment results of five Cooperative Weichteilsarkom Studiengruppe\n                    (CWS) trials and one registry","volume":"69","author":"M Sparber-Sauer","year":"2022","journal-title":"Pediatr Blood Cancer"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2018-5454.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:59:22Z","timestamp":1764161962000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2018-5454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":28,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,6,6]]},"published-print":{"date-parts":[[2023,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2018-5454","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}