{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:33:44Z","timestamp":1789594424004,"version":"build-2803163510"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"the Korean Society for Thrombosis and Hemostasis","award":["KSTH 2017-001"],"award-info":[{"award-number":["KSTH 2017-001"]}]},{"name":"the Soonchunhyang University Research Fund","award":["SURF-20160740"],"award-info":[{"award-number":["SURF-20160740"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>\n            Background\u2003Pregnancy is a transient risk factor for venous thromboembolism (VTE). This second nationwide study aimed to inspect trend changes in the incidence rate of pregnancy-associated VTE (PA-VTE) during the study period (2014\u20132018) compared with that reported in a previous study (2006\u20132010).<\/jats:p><jats:p>\n            Methods\u2003Using the Korean Health Insurance Review and Assessment Service database, we retrospectively identified all PA-VTE events using both diagnostic and medication codes.<\/jats:p><jats:p>\n            Results\u2003Of the 124,228 VTE events, 510 (0.4%) cases of PA-VTE were identified in 499 women (median age: 34 years; range: 20\u201349 years). The incidence rate of PA-VTE\/10,000 deliveries (PA-VTE\/104D) in this second study (2.62) was 3.2 times higher than that in the first study (0.82). In the second study, the PA-VTE\/104D ratio of women in their 40s (5.46) was three times higher than that of women in their 20s (1.80) (relative risk: 3.03; 95% confidence interval: 2.04\u20134.51; p\u2009&lt;\u20090.01). The incidence rate for women in their 40s in the second study was 2.3 times higher than that in the first study. PA-VTE\/104D cases occurred more frequently in multiparous than in primiparous women, in cesarean section cases compared with vaginal delivery, and in multiple rather than single pregnancies. Most PA-VTE cases occurred during the postpartum period (321\/510, 62.9%), of which pulmonary embolism was the most frequently occurring type (231\/321, 72%).<\/jats:p><jats:p>\n            Conclusion\u2003Advanced maternal age, cesarean section, multiparity, and multifetal pregnancies increased the risk of PA-VTE. Obstetricians need to be cautious of VTE, particularly during the postpartum period, in high-risk pregnant patients.<\/jats:p>","DOI":"10.1055\/a-2019-0607","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T23:53:30Z","timestamp":1674604410000},"page":"904-910","source":"Crossref","is-referenced-by-count":14,"title":["Incidence of Pregnancy-Associated Venous Thromboembolism: Second Nationwide Study"],"prefix":"10.1055","volume":"123","author":[{"given":"Hun-Gyu","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Respiratory, Department of Internal Medicine, Soonchunhyang University Gumi Hospital, Soonchunhyang University School of Medicine, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Mee","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1538-7836.2008.02921.x","article-title":"Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study","volume":"6","author":"E R Pomp","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1055\/a-1717-7663","article-title":"Thrombophilia, thrombosis and thromboprophylaxis in pregnancy: for what and in whom?","volume":"42","author":"S 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McMaster Diagnostic Imaging Practice Guidelines Initiative","volume":"128","author":"C Kearon","year":"1998","journal-title":"Ann Intern Med"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2019-0607.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T22:34:13Z","timestamp":1693262053000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2019-0607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":25,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2023,8,28]]},"published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2019-0607","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,24]]},"published":{"date-parts":[[2023,1,24]]}}}