{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:21:17Z","timestamp":1777504877896,"version":"3.51.4"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A synergistic interplay between vitamins K and D appears to exist. We aimed to\n                    investigate for the first time whether the associations of dietary vitamin K\n                    intake and circulating 25(OH)D with serum lipoprotein levels are influenced by\n                    the existence of deficiency of either or both vitamins K and D. Sixty\n                    individuals [24 males, 36(18\u201379) years old] were examined. Vitamin\n                    deficiency of K1 and D were defined as vitamin K1 intake\/body weight\n                    (BW)&lt;1.00\u2009\u03bcg\/kg\/day and circulating\n                    25(OH)D&lt;20\u2009ng\/ml, respectively. In individuals with\n                    vitamin K1 deficiency, the vitamin K1 intake\/BW correlated positively\n                    with high density lipoprotein-cholesterol (HDL-C) (r=0.509,\n                    p=0.008) and negatively with serum triglycerides (TG)\n                    (r=\u20130.638, p=0.001), whereas circulating 25(OH)D\n                    correlated negatively with TG (r=\u20130.609, p=0.001). In\n                    individuals with vitamin D deficiency, the vitamin K1 intake\/BW\n                    correlated positively with HDL-C (r=0.533, p=0.001) and\n                    negatively with TG (r=\u20130.421, p=0.009), while\n                    circulating 25(OH)D correlated negatively with TG (r=\u20130.458,\n                    p=0.004). The above-mentioned associations of vitamin K1\n                    intake\/BW and circulating 25(OH)D with serum lipoproteins were not\n                    detected in individuals without vitamin K1 deficiency or the ones without\n                    vitamin D deficiency. The vitamin K2 intake\/BW correlated negatively\n                    with low density lipoprotein-cholesterol (LDL-C) (r=\u20130.404,\n                    p=0.001). In conclusion, the associations of vitamin K1 intake with TG\n                    and HDL-C and of circulating 25(OH)D with TG were more pronounced in individuals\n                    with deficiency of either or both vitamins K1 and D. Increased dietary vitamin\n                    K2 intake was associated with decreased LDL-C.<\/jats:p>","DOI":"10.1055\/a-2020-2080","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:56Z","timestamp":1677542456000},"page":"196-204","source":"Crossref","is-referenced-by-count":5,"title":["The Associations of Dietary Vitamin K Intake and Circulating Vitamin\n                    25(OH)D with Serum Lipoprotein Levels: The Vitamin Deficiency\n                    Matters"],"prefix":"10.1055","volume":"55","author":[{"given":"Nikolaos","family":"Varsamis","sequence":"additional","affiliation":[{"name":"Atherothrombosis Research Centre, University of Ioannina Faculty of\n                    Medicine, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios A","family":"Christou","sequence":"additional","affiliation":[{"name":"Atherothrombosis Research Centre, University of Ioannina Faculty of\n                    Medicine, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Derdemezis","sequence":"additional","affiliation":[{"name":"Atherothrombosis Research Centre, University of Ioannina Faculty of\n                    Medicine, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Tselepis","sequence":"additional","affiliation":[{"name":"Atherothrombosis Research Centre\/Laboratory of Biochemistry,\n                    Department of Chemistry, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Kiortsis","sequence":"additional","affiliation":[{"name":"Atherothrombosis Research Centre, University of Ioannina Faculty of\n                    Medicine, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/07315724.2009.10718099","article-title":"Dietary phylloquinone intakes and metabolic syndrome in US young adults","volume":"28","author":"Y Pan","year":"2009","journal-title":"J Am Coll Nutr"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1079\/BJN2002582","article-title":"Plasma phylloquinone (vitamin K1) concentration and its relationship to intake\n                    in a national sample of British elderly people","volume":"87","author":"C W Thane","year":"2002","journal-title":"Br J Nutr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1093\/jn\/134.11.3100","article-title":"Dietary intake of menaquinone is associated with a reduced risk of coronary\n                    heart disease: the Rotterdam 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Assoc"},{"key":"ref18","first-page":"436","article-title":"Correlations among vitamin K intake, body fat, lipid profile and glucose\n                    homeostasis in adults and the elderly","volume":"64","author":"EA D Santos","year":"2020","journal-title":"Arch Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.2337\/dc09-2302","article-title":"Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes","volume":"33","author":"J W Beulens","year":"2010","journal-title":"Diabetes Care"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1210\/jc.2014-4449","article-title":"Association between vitamin K and the metabolic syndrome: a 10-year follow-up\n                    study in adults","volume":"100","author":"V Dam","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1017\/BJN20061972","article-title":"Plasma phylloquinone (vitamin K1) concentration and its relationship to intake\n                    in British adults aged 19-64 years","volume":"96","author":"C W Thane","year":"2006","journal-title":"Br J Nutr"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3945\/jn.109.118380","article-title":"Adulthood obesity is positively associated with adipose tissue concentrations of\n                    vitamin K and inversely associated with circulating indicators of vitamin K\n                    status in men and women","volume":"140","author":"M K Shea","year":"2010","journal-title":"J Nutr"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s42000-020-00268-w","article-title":"A critical review of the effects of vitamin K on glucose and lipid homeostasis:\n                    its potential role in the prevention and management of type 2 diabetes","volume":"20","author":"N A Varsamis","year":"2021","journal-title":"Hormones 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osteocalcin, plasma phylloquinone, and urinary\n                    gamma-carboxyglutamic acid in response to altered intakes of dietary\n                    phylloquinone in human subjects","volume":"65","author":"L J Sokoll","year":"1997","journal-title":"Am J Clin Nutr"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2020-2080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T10:57:22Z","timestamp":1683284242000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2020-2080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,27]]},"references-count":33,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,2,27]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2020-2080","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,27]]}}}