{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:10:52Z","timestamp":1790619052723,"version":"4.1.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Newborn screening for congenital adrenal hyperplasia (CAH) has\n                    benefits with a high adoption rate worldwide. It also has problems of high false\n                    positives, which can cause stress to the patient\u2019s family with economic\n                    losses and unnecessary visits of newborns to hospitals. Therefore, we\n                    investigated the influence of birth weight (BW), gestational age (GA), and GA\n                    with sampling time on 17-hydroxyprogesterone (17-OHP) concentration and\n                    attempted to establish the 17-OHP cutoff values in preterm, low birth weight\n                    (LBW), and sick newborns.<\/jats:p><jats:p>\n          Methods Newborns (n=1,071) born between October 2020 and January\n                    2022 were screened for CAH. Samples from neonates were collected on filter paper\n                    with the heel prick method. 17-OHP concentration was measured by time-resolved\n                    immunofluorescence with an AutoDELFIA Neonatal 17-hydroxyprogesteron kit and\n                    grouped in relation to BW, GA, and GA with sampling time.<\/jats:p><jats:p>\n          Results The median age of newborns at neonatal sample collection was 6\n                    days. 17-OHP concentration showed a statistically significant negative\n                    correlation with BW (r=\u22120.488, p&lt;0.001)\n                    and GA (r=\u22120.560, p&lt;0.001). Full-term and\n                    preterm subgroups had a similar decreasing tendency of 17-OHP concentration with\n                    increasing sampling time. Application of newly establishing cutoff criteria\n                    significantly reduced recall rates to 1.16%, 0.9%, and\n                    1.75% according to each criterion of BW, GA, and GA with sampling time,\n                    respectively.<\/jats:p><jats:p>\n          Conclusions This study presents new 17-OHP cutoff values for preterm, LBW,\n                    and sick newborns. These data in our laboratory can be used as a reference by\n                    other laboratories for establishing new cutoff criteria to help lower the high\n                    recall rate and reduce unnecessary follow-up tests.<\/jats:p>","DOI":"10.1055\/a-2022-8399","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:05:46Z","timestamp":1677629146000},"page":"216-221","source":"Crossref","is-referenced-by-count":5,"title":["Establishing 17-Hydroxyprogesterone Cutoff Values for Congenital\n                    Adrenal Hyperplasia in Preterm, Low Birth Weight, and Sick\n                    Newborns"],"prefix":"10.1055","volume":"131","author":[{"given":"Young Ahn","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Soonchunhyang University Cheonan\n                    Hospital, Soonchunhyang University College of Medicine, Cheonan,\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhyeon","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Soonchunhyang University Cheonan\n                    Hospital, Soonchunhyang University College of Medicine, Cheonan,\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Soonchunhyang University Cheonan\n                    Hospital, Soonchunhyang University College of Medicine, Cheonan,\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Soonchunhyang University Cheonan\n                    Hospital, Soonchunhyang University College of Medicine, Cheonan,\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Soonchunhyang University Cheonan\n                    Hospital, Soonchunhyang University College of Medicine, Cheonan,\n                    Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1056\/NEJMra021561","article-title":"Congenital adrenal hyperplasia","volume":"349","author":"P W Speiser","year":"2003","journal-title":"N Engl J Med"},{"key":"ref2","first-page":"245","article-title":"Congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"21","author":"P C White","year":"2000","journal-title":"Endocr Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/ijns7030036","article-title":"Thirty-year 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