{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T14:40:28Z","timestamp":1780929628245,"version":"3.54.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"financially supported by statutory","award":["(503\/1\u2013107\u201303\/503\u201311\u2013\n                        001\u201319\u201300"],"award-info":[{"award-number":["(503\/1\u2013107\u201303\/503\u201311\u2013\n                        001\u201319\u201300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction We aimed to assess renin, aldosterone, and cortisol in the\n                    early stages of pregnancy-induced hypertension (PIH), i.\u2009e., at the time\n                    of diagnosis.<\/jats:p><jats:p>\n          Methods During the postural test, we measured aldosterone, renin [Liason\n                    DiaSorin Inc. (Italy)], as well as cortisol, sodium, potassium, and 24-h urinary\n                    sodium and potassium excretion in 62 women with newly diagnosed PIH, 70 healthy\n                    women during the 3rd trimester of pregnancy, and in 22 healthy non-pregnant\n                    women.<\/jats:p><jats:p>\n          Results In all groups, there was a significant increase in aldosterone and\n                    renin in upright versus supine posture (p&lt;0.01). Both supine and upright\n                    aldosterone concentrations were higher in healthy pregnant women than in women\n                    with PIH and the lowest in healthy not-pregnant [supine\n                    (median\u00b1intequartile range): 25.04\u00b118.4\u2009ng\/dL,\n                    18.03\u00b112.58\u2009ng\/dL, and\n                    7.48\u00b14.78\u2009ng\/dL, p&lt;0.001, upright:\n                    31.60\u00b121.32\u2009ng\/dL,\n                    25.11\u00b113.15\u2009ng\/dL, and\n                    12.4\u00b112.4\u2009ng\/dL, p&lt;0.001, for healthy pregnant,\n                    pregnant with PIH, and non-pregnant, respectively]. Supine renin concentrations\n                    were higher only in healthy pregnant (p&lt;0.001), while in the upright\n                    position, there was a difference only between healthy pregnant and women with\n                    PIH (p=0.002). Both in supine and upright positions, there was no\n                    difference in the aldosterone-to-renin ratio between healthy pregnant women and\n                    women with PIH, though, in both groups, the ratio was higher than in\n                    non-pregnant women (p&lt;0.001). Morning cortisol concentrations and 24-h\n                    urinary sodium excretion were lower in women with PIH than in healthy pregnant\n                    (p&lt;0.001, p=0.002, respectively).<\/jats:p><jats:p>\n          Conclusion Hyperaldosteronism is not involved in the etiology of PIH. In\n                    PIH, there is also a tendency towards lower sodium excretion and lower morning\n                    cortisol concentrations.<\/jats:p>","DOI":"10.1055\/a-2025-0510","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:09:04Z","timestamp":1676938144000},"page":"222-227","source":"Crossref","is-referenced-by-count":6,"title":["Renin, Aldosterone, and Cortisol in Pregnancy-Induced\n                    Hypertension"],"prefix":"10.1055","volume":"131","author":[{"given":"Krzysztof C","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Medical University\n                    of Lodz, Lodz, Poland"},{"name":"Department of Endocrinology and Metabolic Diseases, Polish\n                    Mother\u2019s Memorial Hospital \u2013 Research Institute, Lodz,\n                    Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Tadros-Zins","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Polish Mother\u2019s\n                    Memorial Hospital \u2013 Research Institute, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Horzelski","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Lodz,\n                    Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Krekora","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Polish Mother\u2019s\n                    Memorial Hospital \u2013 Research Institute, Lodz, Poland"},{"name":"Department of Gynaecology and Obstetrics, 2nd Chair of Gynaecology and\n                    Obstetrics, Medical University of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Lewinski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, Medical University\n                    of Lodz, Lodz, Poland"},{"name":"Department of Endocrinology and Metabolic Diseases, Polish\n                    Mother\u2019s Memorial Hospital \u2013 Research Institute, Lodz,\n                    Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2050312119843700","DOI":"10.1177\/2050312119843700","article-title":"Hypertension in pregnancy: Pathophysiology and treatment","volume":"7","author":"S Braunthal","year":"2019","journal-title":"SAGE Open Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.14310\/horm.2002.1582","article-title":"Pregnancy-induced hypertension","volume":"14","author":"E Kintiraki","year":"2015","journal-title":"Hormones"},{"key":"ref4","first-page":"229","article-title":"Progression of gestational 362 hypertension to preeclampsia","volume":"82","author":"J F Romero-Arauz","year":"2014","journal-title":"Ginecol Obstet Mex"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: Pathogenesis, novel diagnostics and therapies","volume":"15","author":"E A Phipps","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"713","DOI":"10.3109\/10641969709083181","article-title":"The renin-angiotensin system in preeclapsia","volume":"19","author":"M A Brown","year":"1997","journal-title":"Clin Exp Hypertens"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1007\/s12020-020-02296-3","article-title":"Longitudinal study of angiotensin peptides in normal and pre-eclamptic\n                    pregnancy","volume":"69","author":"K B Brosnihan","year":"2020","journal-title":"Endocrine"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1097\/00004872-199917090-00012","article-title":"Plasma human atrial natriuretic peptide, endothelin-1, aldosterone and\n                    plasma-renin activity in pregnancy-induced hypertension","volume":"17","author":"K G Zafirovska","year":"1999","journal-title":"J Hypertens"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1055\/s-0031-1295460","article-title":"Factors affecting the aldosterone\/renin ratio","volume":"44","author":"M Stowasser","year":"2012","journal-title":"Horm Metab Res"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"117","DOI":"10.5603\/AH.a2019.0011","article-title":"Management of hypertension in pregnancy \u2013 prevention, diagnosis,\n                    treatment and long-term prognosis. A position statement based on expert\n                    consensus of the Polish Society of Hypertension, Polish Cardiac Society and\n                    Polish Society of Gynecologists and Obstetricians","volume":"23","author":"A Prejbisz","year":"2019","journal-title":"Arterial Hypertens"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1365-2362.2008.02060.x","article-title":"The serum sodium to urinary sodium to (serum potassium)2 to urinary\n                    potassium ratio in patients with primary aldosteronism","volume":"39","author":"H S Willenberg","year":"2009","journal-title":"Eur J Clin Invest"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"17156","DOI":"10.1038\/s41598-021-96628-6","article-title":"Novel metabolomic profile of subjects with non-classic apparent\n                    mineralocorticoid excess","volume":"11","author":"A Tapia-Castillo","year":"2021","journal-title":"Sci Rep"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1093\/ajh\/hpt091","article-title":"Bimodal aldosterone distribution in low-renin hypertension","volume":"26","author":"E V Adlin","year":"2013","journal-title":"Am J Hypertens"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/01.CIR.39.5.685","article-title":"Salivary sodium-potassium ratio and plasma renin activity in hypertension","volume":"39","author":"E V Adlin","year":"1969","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0002-9343(72)90036-8","article-title":"Hyporeninemic hypertension","volume":"52","author":"M G Crane","year":"1972","journal-title":"Am J Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3390\/diagnostics10080545","volume":"10","author":"E 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Fagundes","year":"1992","journal-title":"Hypertension"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/cen.14199","article-title":"Age- and sex-specific reference ranges are needed for the\n                    aldosterone\/renin ratio","volume":"93","author":"P Solanki","year":"2020","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/clinem\/dgaa282","article-title":"Development and validation criteria for sparing confirmatory tests in diagnosing\n                    primary aldosteronism","volume":"105","author":"K Wang","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"8647026","DOI":"10.1155\/2018\/8647026","article-title":"Age-related cut-offs of plasma aldosterone\/renin concentrations for\n                    primary aldosteronism screening","volume":"2018","author":"L Ma","year":"2018","journal-title":"Int J Endocrinol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1161\/HYPERTENSIONAHA.119.12924","article-title":"Aldosterone, salt, and potassium intakes as predictors of pregnancy outcome,\n                    including preeclampsia","volume":"74","author":"A Birukov","year":"2019","journal-title":"Hypertension"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1196\/annals.1290.016","article-title":"Maternal and fetal hypothalamic-pituitary adrenal axes during pregnancy and\n                    postpartum","volume":"997","author":"G Mastorakos","year":"2003","journal-title":"Ann NY Acad Sci"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"5279462","DOI":"10.1155\/2016\/5279462","article-title":"11\u03b2-Hydroxysteroid dehydrogenase 2 in preeclampsia","volume":"2016","author":"K Kosicka","year":"2016","journal-title":"Int J Endocrinol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s12020-018-1586-4","article-title":"Increased cortisol metabolism in women with pregnancy-related hypertension","volume":"61","author":"K Kosicka","year":"2018","journal-title":"Endocrine"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1111\/j.1365-2265.2007.02826.x","article-title":"Reduced maternal corticosteroid-binding globulin and cortisol levels in\n                    pre-eclampsia and gamete recipient pregnancies","volume":"66","author":"J T Ho","year":"2007","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2025-0510.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T23:33:14Z","timestamp":1681428794000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2025-0510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,20]]},"references-count":29,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,4,13]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2025-0510","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,20]]}}}