{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:26:19Z","timestamp":1793395579059,"version":"4.5.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n            Background\u2002Familial adenomatous polyposis (FAP) is a rare inherited syndrome that predisposes the patient to cancer. Treatment of FAP-related ampullary lesions is challenging and the role of endoscopic papillectomy has not been elucidated. We retrospectively analyzed the outcomes of endoscopic papillectomy in matched cohorts of FAP-related and sporadic ampullary lesions (SALs).<\/jats:p><jats:p>\n            Methods\u2002This retrospective multicenter study included 1422 endoscopic papillectomy procedures. Propensity score matching including age, sex, comorbidity, histologic subtype, and size was performed. Main outcomes were complete resection (R0), technical success, complications, and recurrence.<\/jats:p><jats:p>\n            Results\u2002Propensity score matching identified 202 patients (101 FAP, 101 SAL) with comparable baseline characteristics. FAP patients were mainly asymptomatic (79.2\u200a% [95\u200a%CI 71.2\u201387.3] vs. 46.5\u200a% [95\u200a%CI 36.6\u201356.4]); P\u200a&lt;\u200a0.001). The initial R0 rate was significantly lower in FAP patients (63.4\u200a% [95\u200a%CI 53.8\u201372.9] vs. 83.2\u200a% [95\u200a%CI 75.8\u201390.6]; P\u200a=\u200a0.001). After repeated interventions (mean 1.30 per patient), R0 was comparable (FAP 93.1\u200a% [95\u200a%CI 88.0\u201398.1] vs. SAL 97.0\u200a% [95\u200a%CI 93.7\u2013100]; P\u200a=\u200a0.19). Adverse events occurred in 28.7\u200a%. Pancreatitis and bleeding were the most common adverse events in both groups. Severe adverse events were rare (3.5\u200a%). Overall, 21 FAP patients (20.8\u200a% [95\u200a%CI 12.7\u201328.8]) and 16 SAL patients (15.8\u200a% [95\u200a%CI 8.6\u201323.1]; P\u200a=\u200a0.36) had recurrence. Recurrences occurred later in FAP patients (25 [95\u200a%CI 18.3\u201331.7] vs. 2 [95\u200a%CI CI 0.06\u20133.9] months).<\/jats:p><jats:p>\n            Conclusions\u2002Endoscopic papillectomy was safe and effective in FAP-related ampullary lesions. Criteria for endoscopic resection of ampullary lesions can be extended to FAP patients. FAP patients have a lifetime risk of relapse even after complete resection, and require long-time surveillance.<\/jats:p>","DOI":"10.1055\/a-2029-2935","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:14:41Z","timestamp":1675728881000},"page":"709-718","source":"Crossref","is-referenced-by-count":19,"title":["Endoscopic papillectomy for ampullary lesions in patients with familial adenomatous polyposis compared with sporadic lesions: a propensity score-matched cohort"],"prefix":"10.1055","volume":"55","author":[{"given":"Kien","family":"Vu Trung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Medical Department II, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einas","family":"Abou-Ali","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Digestive Oncology and Endoscopy, Cochin Hospital, Paris Descartes University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-0942","authenticated-orcid":false,"given":"Fabrice","family":"Caillol","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Institut Paoli Calmettes, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8708-3280","authenticated-orcid":false,"given":"Woo H.","family":"Paik","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Napoleon","sequence":"additional","affiliation":[{"name":"Hopital prive Jean Mermoz, Ramsay Generale de Sante, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viliam","family":"Masaryk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Diabetes and General Internal Medicine, SRH Wald-Klinikum Gera, Gera, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-4853","authenticated-orcid":false,"given":"Sophia E.","family":"van der Wiel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-7453","authenticated-orcid":false,"given":"Enrique","family":"P\u00e9rez-Cuadrado-Robles","sequence":"additional","affiliation":[{"name":"Interventional Endoscopy, H\u00f4pital Europ\u00e9en Georges-Pompidou, Department of Gastroenterology, Georges-Pompidou European Hospital, Paris, France"},{"name":"Department of Gastroenterology, Cliniques universitaires Saint-Luc, Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Musquer","sequence":"additional","affiliation":[{"name":"Clinique Sant\u00e9 Atlantique, Saint Herblain, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Halimi","sequence":"additional","affiliation":[{"name":"Division of Surgery, CLINTEC, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Surgical and Perioperative Sciences, Surgery, University of Ume\u00e5, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Soares","sequence":"additional","affiliation":[{"name":"Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois R.","family":"Souche","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Centre Hospitalier Universitaire de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Seyfried","sequence":"additional","affiliation":[{"name":"Interdisciplinary Endoscopy Unit, Mannheim Medical Center, Ruprecht-Karls-University Heidelberg, Mannheim, Germany"},{"name":"Department of Surgery, Mannheim Medical Center, Ruprecht-Karls-University Heidelberg, Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Petrone","sequence":"additional","affiliation":[{"name":"Endosonography Unit, Pancreato-Biliary Endoscopy and Endosonography Division, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Crippa","sequence":"additional","affiliation":[{"name":"Department of Pancreatic Surgery, Vita Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kleemann","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Rheumatology, Carl-Thiem-Klinikum Cottbus, Cottbus, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Albers","sequence":"additional","affiliation":[{"name":"Department of Medicine and Gastroenterology, Contilia Clinic Essen, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias J.","family":"Weism\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine \u2013 Gastroenterology and Oncology, Vivantes Humboldt Hospital, Berlin, Germany"},{"name":"Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Dugic","sequence":"additional","affiliation":[{"name":"Division of Surgery, CLINTEC, Karolinska Institutet, Stockholm, Sweden"},{"name":"Department of Gastroenterology, Friedrich-Alexander-University Erlangen-Nuremberg, Medical Campus Oberfranken, Bayreuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Medicine, Gastroenterology, Hematology, Oncology, Pneumology, Diabetes and Infectious Diseases; RKH Clinic Ludwigsburg, Ludwigsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edris","family":"Wedi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Gastrointestinal Oncology, University Medicine G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"Department of Gastroenterology, Gastrointestinal Oncology and Interventional Endoscopy, Sana Clinic Offenbach, Offenbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Schiemer","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University of Freiburg Medical Center, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Regner","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Section for Surgery, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Gaujoux","sequence":"additional","affiliation":[{"name":"Department of Digestive and HBP Surgery, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re APHP, M\u00e9decine Sorbonne Universit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-3164","authenticated-orcid":false,"given":"Marcus","family":"Hollenbach","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Medical Department II, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ESAP Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3322\/CA.2007.0010","article-title":"Cancer statistics, 2008","volume":"58","author":"A Jemal","year":"2008","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.23736\/S1121-421X.18.02543-6","article-title":"Demographics, tumor characteristics, treatment, and clinical outcomes of 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Lepist\u00f6","year":"2009","journal-title":"Endoscopy"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4174\/astr.2018.95.1.22","article-title":"Transduodenal ampullectomy for ampullary tumors \u2013 single center experience of consecutive 26 patients","volume":"95","author":"S Hong","year":"2018","journal-title":"Ann Surg Treat Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.3748\/wjg.v20.i6.1537","article-title":"Endoscopic papillectomy: indications, techniques, and results","volume":"20","author":"G D De Palma","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.3390\/jcm9113622","article-title":"Systematic review with meta-analysis: endoscopic and surgical resection for ampullary lesions","volume":"9","author":"C Heise","year":"2020","journal-title":"J Clin 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Leerdam","year":"2019","journal-title":"Endoscopy"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.gie.2013.08.006","article-title":"Endoscopic papillectomy: risk factors for incomplete resection and recurrence during long-term follow-up","volume":"79","author":"W Ridtitid","year":"2014","journal-title":"Gastrointest Endosc"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.gie.2020.01.028","article-title":"American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in familial adenomatous polyposis syndromes","volume":"91","author":"J Yang","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/gutjnl-2013-305516","article-title":"Long-term adenoma recurrence following wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal neoplasia is infrequent: results and risk factors in 1000 cases from the Australian Colonic EMR (ACE) study","volume":"64","author":"A Moss","year":"2015","journal-title":"Gut"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2029-2935.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T01:11:24Z","timestamp":1690506684000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2029-2935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":40,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2023,7,27]]},"published-print":{"date-parts":[[2023,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2029-2935","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,6]]},"published":{"date-parts":[[2023,2,6]]}}}