{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:37:13Z","timestamp":1789983433421,"version":"4.0.1"},"reference-count":70,"publisher":"Georg Thieme Verlag KG","issue":"01\/02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Das Delirium tremens (DT) ist eine weit verbreitete und\n                    potentiell vital bedrohliche Komplikation des Alkoholentzugs. Die\n                    medikament\u00f6se Behandlung eines DT spielt sowohl eine wichtige Rolle in\n                    der station\u00e4ren suchtmedizinischen Versorgung als auch in anderen\n                    medizinischen Fachbereichen, in denen ein Alkoholentzugsdelir sekund\u00e4r\n                    durch die Hospitalisierung auftreten kann. Patienten im DT m\u00fcssen\n                    hochdosiert mit Benzodiazepinen (bei geriatrischen Patienten kurzwirksame\n                    Benzodiazepine zur Vermeidung einer Akkumulierung) oder Clomethiazol sowie bei\n                    produktiv-psychotischen Symptomen zus\u00e4tzlich antipsychotisch behandelt\n                    werden. Eine differenzierte Empfehlung zur konkreten Behandlung mit\n                    Antipsychotika im DT fehlt bisher. Die hier vorliegende \u00dcbersicht\n                    diskutiert die Empfehlungen der Fachgesellschaften mit anderen in der Literatur\n                    zug\u00e4nglichen Ergebnissen bez\u00fcglich der Wahl eines\n                    Antipsychotikums zur Behandlung des DT. Ziel: Systematische Darstellung\n                    relevanter Antipsychotika zur Behandlung des DT.<\/jats:p><jats:p>\n          Methode Es erfolgte eine systematische Literaturrecherche in Pubmed und\n                    Scopus nach Original- und \u00dcbersichtsarbeiten zu Antipsychotika im\n                    Alkoholentzug und DT. Letztmalig erfolgte eine Suche am 22. Mai 2022. Weiter\n                    wurden internationale Leitlinien ber\u00fccksichtigt. Die\n                    \u00dcbersichtsarbeit wurde mittels PROSPERO registriert (https:\/\/www.crd.york.ac.uk\/prospero\/); CRD42021264611.<\/jats:p><jats:p>\n          Ergebnisse Haloperidol wird besonders auf der Intensivstation empfohlen.\n                    Die Datenlage zur differentiellen Verwendung von atypischen Antipsychotika im DT\n                    ist weiter insuffizient. Insgesamt gilt es, die Medikation immer in Kombination\n                    mit Benzodiazepinen durchzuf\u00fchren und potentielle Komplikationen wie das\n                    maligne neuroleptische Syndrom, QTc-Verl\u00e4ngerungen und\n                    extrapyramidal-motorische St\u00f6rungen sowie komplikative\n                    Entzugskrampfanf\u00e4lle durch Senkung der Krampfschwelle, unter der\n                    Verwendung von Antipsychotika, zu beachten.<\/jats:p><jats:p>\n          Schlussfolgerung Die Behandlung mit Antipsychotika im DT sollte nach der\n                    Erfahrung des Behandlers erfolgen. Eine klare Empfehlung au\u00dfer die Gabe\n                    von Haloperidol existiert nicht.<\/jats:p>","DOI":"10.1055\/a-2029-6387","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T23:36:34Z","timestamp":1679614594000},"page":"36-52","source":"Crossref","is-referenced-by-count":4,"title":["Systematische \u00dcbersichtsarbeit Antipsychotische Behandlung\n                    des Alkoholentzugssyndroms: Fokus Delirium Tremens"],"prefix":"10.1055","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-9535","authenticated-orcid":false,"given":"Timo Jendrik","family":"Faustmann","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie,\n                    Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, D\u00fcsseldorf,\n                    Germany"},{"name":"Abteilung f\u00fcr Allgemeine Psychiatrie 2, LVR-Klinikum\n                    D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrella","family":"Paschali","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie,\n                    Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf, D\u00fcsseldorf,\n                    Germany"},{"name":"Abteilung f\u00fcr Gerontopsychiatrie, LVR-Klinikum\n                    D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Kojda","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmakologie, Heinrich-Heine-Universit\u00e4t\n                    D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonhard","family":"Schilbach","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Allgemeine Psychiatrie 2, LVR-Klinikum\n                    D\u00fcsseldorf, D\u00fcsseldorf, 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