{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:10:21Z","timestamp":1750939821283},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Dieser Fallbericht beschreibt den Krankheitsverlauf der sporadischen\n                    K\u00e4lberleukose bei einem 8 Wochen alten m\u00e4nnlichen Kreuzungskalb\n                    der Rasse Red Holstein\u00d7Fleckvieh. Das Kalb wurde initial wegen einer\n                    Bronchopneumonie vorgestellt. Dabei fiel eine f\u00fcr K\u00e4lbergrippe\n                    untypische symmetrische hochgradige Vergr\u00f6\u00dferung der subkutanen\n                    Lymphknoten auf. In Verbindung mit dem massenhaften Vorliegen von Blasten im\n                    peripheren Blut und dem sonografischen Befund der Lymphknoten wurde die\n                    Verdachtsdiagnose sporadische K\u00e4lberleukose gestellt. Drei Wochen nach\n                    der Erstvorstellung verstarb das Kalb pl\u00f6tzlich. Die Sektion ergab eine\n                    hochgradige Vergr\u00f6\u00dferung aller Lymphknoten und eine hochgradige\n                    Infiltration nahezu aller Organe und Gewebe mit einer monomorphen\n                    Rundzellpopulation. Dieser Zelltyp wurde auch in einem Knochenmarkausstrich\n                    zytologisch nachgewiesen. Die immunhistochemische Untersuchung mit den Markern\n                    Pax5 und CD 20 f\u00fcr B-Zellen verlief mit positivem Ergebnis. Die\n                    virologische Untersuchung auf bovine Leukoseviren (BLV) war negativ.<\/jats:p><jats:p>Zusammen mit der Diagnose eines multizentrischen B-Zell-Lymphoms sprachen die\n                    Untersuchungsergebnisse f\u00fcr das Vorliegen einer sporadischen\n                    K\u00e4lberleukose.<\/jats:p>","DOI":"10.1055\/a-2030-6701","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T22:53:53Z","timestamp":1685055233000},"page":"109-115","source":"Crossref","is-referenced-by-count":2,"title":["Multizentrisches B-Zell-Lymphom bei einem 8 Wochen alten\n                    Kalb"],"prefix":"10.1055","volume":"51","author":[{"given":"Marie","family":"Frischkorn","sequence":"additional","affiliation":[{"name":"Praxis und Klinik f\u00fcr Rinder, Dr. Doris Jahn-Falk, Dr. Konrad\n                    Bierhorst, Hofbieber"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fortelny","sequence":"additional","affiliation":[{"name":"Praxis und Klinik f\u00fcr Rinder, Dr. Doris Jahn-Falk, Dr. Konrad\n                    Bierhorst, Hofbieber"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Ciurkiewicz","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie der Stiftung Tier\u00e4rztliche\n                    Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie der Stiftung Tier\u00e4rztliche\n                    Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Jahn-Falk","sequence":"additional","affiliation":[{"name":"Praxis und Klinik f\u00fcr Rinder, Dr. Doris Jahn-Falk, Dr. Konrad\n                    Bierhorst, Hofbieber"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"ref1","first-page":"145","volume-title":"H\u00e4matopoetische Tumoren. Hrsg. Spezielle Pathologie f\u00fcr die\n                    Tiermedizin","author":"A Beineke","year":"2020"},{"key":"ref3","first-page":"147","volume-title":"3.1 Krankheiten der Lymphknoten und Lymphgef\u00e4\u00dfe. In: Dirksen G,\n                    Baumgartner W, Rosenberger G, Hrsg. Innere Medizin und Chirurgie des Rindes","author":"M St\u00f6ber","year":"2006"},{"key":"ref4","first-page":"1","volume-title":"Enzootische Leukose der Rinder (bovines Leukosevirus): Amtliche Methode und\n                    Falldefinition. In: Amtliche Methodensammlung und Falldefinitionen:\n                    Anzeigepflichtige Tierseuchen","year":"2019"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.2044-3870.2010.tb00287.x","article-title":"An atypical presentation of sporadic bovine leukosis in a steer","volume":"15","author":"N Lyons","year":"2010","journal-title":"Livestock"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1136\/vr.153.17.525","article-title":"Clinical, haematological, immunohistochemical and pathological findings in 10\n                    cattle with cutaneous lymphoma","volume":"153","author":"G Schweizer","year":"2003","journal-title":"Vet Rec"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.15653\/TPG-150514","article-title":"Sporadische kutane T-Zell-Leukose mit Beteiligung von Lymphknoten und inneren\n                    Organen bei einer Holstein-Kuh","volume":"44","author":"M Freick","year":"2016","journal-title":"Tier\u00e4rztl Prax Ausg G Gro\u00dftiere\n                    Nutztiere"},{"key":"ref8","first-page":"3","volume":"43","author":"S H Hendrick","year":"2002","journal-title":"Atypical sporadic bovine leukosis in a beef feedlot\n                    heifer"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1136\/vr.101885","article-title":"Atypical form of sporadic bovine leukosis (SBL) in the Netherlands","volume":"173","author":"W Gr\u00fcnberg","year":"2013","journal-title":"Vet Rec"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1024\/0036-7281\/a000177","article-title":"Ver\u00e4nderungen an den Konjunktiven bei einem Braunviehrind mit malignem\n                    Lymphom","volume":"153","author":"U Braun","year":"2011","journal-title":"Schweiz Arch F\u00fcr Tierheilkd"},{"key":"ref11","first-page":"3","volume":"35","author":"O Oliver-Espinosa","year":"1994","journal-title":"Sporadic bovine leukosis associated with ataxia and tibiotarsal joint\n                    swelling: A case report"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1177\/104063870701900422","article-title":"Precursor B-1 B Cell Lymphoma in a Newborn Calf","volume":"19","author":"S Yamamoto","year":"2007","journal-title":"J Vet Diagn Invest"},{"key":"ref13","first-page":"3","volume":"39","author":"P Dubreuil","year":"1998","journal-title":"Atypical sporadic lymphosarcoma in a 7-month-old Holstein\n                    heifer"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/j.1348-0421.1986.tb02995.x","article-title":"No Involvement of Bovine Leukemia Virus in Sporadic Bovine Lymphosarcoma","volume":"30","author":"Y Ogawa","year":"1986","journal-title":"Microbiol Immunol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1177\/030098589503200610","article-title":"Phenotypic Analysis of Neoplastic Cells from Calf, Thymic, and Intermediate\n                    Forms of Bovine Leukosis","volume":"32","author":"M Asahina","year":"1995","journal-title":"Vet Pathol"},{"key":"ref16","first-page":"280","article-title":"Sporadic bovine leukosis: a description of eight calves received at Animal\n                    Diseases Research Institute from 1974-1980","volume":"21","author":"A Bundza","year":"1980","journal-title":"Can Vet J Rev Veterinaire Can"},{"key":"ref17","first-page":"187","volume-title":"Diagnostik h\u00e4matopoetischer Neoplasien. In: Moritz A, Hrsg. Klinische\n                    Labordiagnostik in der Tiermedizin","author":"A Moritz","year":"2014"},{"key":"ref18","first-page":"160","volume-title":"Knochenmarkpunktion. In: Moritz A, Hrsg. 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