{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:56:28Z","timestamp":1759481788143},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Dieser \u00dcbersichtsartikel bietet einen \u00dcberblick \u00fcber klinisch sinnvolle Anwendungsgebiete einer Next-Generation-Sequencing-basierten (NGS) Multi-Genpanel-Teststrategie in den Bereichen Onkologie, heredit\u00e4rer Tumorsyndrome und H\u00e4matologie. Bei soliden Tumoren (z.B. Lungenkarzinom, Kolonrektalkarzinom) tr\u00e4gt die Detektion somatischer Mutationen nicht nur zu einer besseren diagnostischen, sondern auch therapeutischen Stratifizierung der Betroffenen bei. Die zunehmende genetische Komplexit\u00e4t heredit\u00e4rer Tumorsyndrome (z.B. Brust- und Ovarialkarzinom, Lynchsyndrom\/Polypose) erfordert in betroffenen Familien eine Multi-Genpanel-Analyse von Keimbahnmutationen. Ein weiteres sinnvolles Indikationsgebiet einer Multi-Genpanel-Diagnostik und Prognoseabsch\u00e4tzung sind akute und chronische myeloische Erkrankungen. Die Kriterien der WHO-Klassifikation und des \u201eEuropean LeukemiaNet\u201c-Prognosesystems der akuten myeloischen Leuk\u00e4mie k\u00f6nnen nur durch eine Multi-Genpanel-Teststrategie erf\u00fcllt werden.<\/jats:p>","DOI":"10.1055\/a-2033-5329","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T22:37:46Z","timestamp":1684795066000},"page":"695-702","source":"Crossref","is-referenced-by-count":1,"title":["Klinische Anwendungsbeispiele einer Next-Generation-Sequencing-basierten Multi-Genpanel-Analyse"],"prefix":"10.1055","volume":"148","author":[{"given":"Dietmar","family":"Enko","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4t Graz Klinisches Institut f\u00fcr Medizinische und Chemische Labordiagnostik, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Schaflinger","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Humangenetik, Medizinische Universit\u00e4t Graz, Neue Stiftingtalstra\u00dfe 2, 8010 Graz, Austria,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Klinisches Institut f\u00fcr Pharmakogenetische Wissenschaft, Cambell Family Mental Health Research Institute, Zentrum f\u00fcr Suchtkrankheit und psychische Gesundheit, College Street 250, Toronto, ON M5T 1R8, Toronto, Kanada,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1055\/a-1924-6646","article-title":"The Impact of Next-Generation Sequencing on Medical Genetic Diagnostics and Counseling","volume":"147","author":"E Schaflinger","year":"2022","journal-title":"Dtsch Med Wochenschr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/cas.13837","article-title":"Next generation sequencing-based gene 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