{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T04:36:57Z","timestamp":1681447017316},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective To review the presentation characteristics, clinical and\n                    hormonal evaluations, and histopathological results of patients with adrenal\n                    lesions over a 21-year period and evaluate the changes across the two\n                    decades.<\/jats:p><jats:p>\n          Methods This single-center, retrospective study included 1003 patients\n                    with adrenal lesions who presented to our department between 2000 and 2021.\n                    Clinical, metabolic, hormonal, radiological, and pathological data of the\n                    patients were collected.<\/jats:p><jats:p>\n          Results Forty-seven percent of the lesions were non-functioning adrenal\n                    adenomas. Possible autonomous and autonomous cortisol secretion were detected in\n                    22.2% of the patients. The percentages of the patients diagnosed with\n                    pheochromocytoma, primary hyperaldosteronism, adrenal Cushing syndrome,\n                    adrenocortical carcinoma, and adrenal metastasis were 7.4%,\n                    4.8%, 4.7%, 0.9%, and 5.6%, respectively.\n                    Adrenalectomy was performed in 31.3% of the patients. Functional adrenal\n                    lesions were the leading cause of surgery (46.5%), followed by large\n                    size and\/or suspicious imaging features (38.6%). Among the\n                    patients referred to surgery due to large size (\u22656\u2009cm), the\n                    diagnosis in 19% was metastasis, and in 12.1%, it was primary\n                    adrenocortical carcinoma. In patients with adrenal lesions with a size of\n                    4\u20136\u2009cm and suspicious imaging properties, the rates of\n                    metastasis and primary adrenocortical carcinoma were 44.4% and\n                    4.8%, respectively. From the first to the second decade, major\n                    differences in presentation characteristics were increased detection of\n                    bilateral lesions and increased prevalence of possible autonomous and autonomous\n                    cortisol secretion.<\/jats:p><jats:p>\n          Conclusions Adrenal lesions are common in the adult population, and while\n                    it is important to avoid overtreatment, hormone secretion, and malignancy should\n                    not be overlooked.<\/jats:p>","DOI":"10.1055\/a-2035-6091","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:13:41Z","timestamp":1676420021000},"page":"242-250","source":"Crossref","is-referenced-by-count":0,"title":["Many Faces of Adrenal Lesions in a Large Patient Cohort: What Has\n                    Changed Over the Last Two Decades?"],"prefix":"10.1055","volume":"131","author":[{"given":"Basak Ozgen","family":"Saydam","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Dokuz Eylul University\n                    Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Baris","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dokuz Eylul University Faculty of Medicine,\n                    Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman Cem","family":"Adiyaman","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Dokuz Eylul University\n                    Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tevfik","family":"Demir","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Dokuz Eylul University\n                    Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ali","family":"Kocdor","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dokuz Eylul University, Izmir,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Urology, Dokuz Eylul University, Izmir,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Secil","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dokuz Eylul University Faculty of Medicine,\n                    Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"Yener","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Dokuz Eylul University\n                    Faculty of Medicine, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-16-0467","article-title":"Management of adrenal incidentalomas: European Society of Endocrinology Clinical\n                    Practice Guideline in collaboration with the European Network for the Study of\n                    Adrenal Tumors","volume":"175","author":"M Fassnacht","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1530\/eje.0.1490273","article-title":"Prevalence and natural history of adrenal incidentalomas","volume":"149","author":"L Barzon","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"ref3","first-page":"460","article-title":"Incidentally discovered adrenal masses","volume":"16","author":"R T Kloos","year":"1995","journal-title":"Endocr Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2214\/AJR.07.2799","article-title":"The incidental adrenal mass on CT: Prevalence of adrenal disease in 1,049\n                    consecutive adrenal masses in patients with no known malignancy","volume":"190","author":"J H Song","year":"2008","journal-title":"AJR Am J Roentgenol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12020-009-9260-5","article-title":"Adrenal incidentaloma, clinical, metabolic, follow-up aspects: Single centre\n                    experience","volume":"37","author":"A Comlekci","year":"2010","journal-title":"Endocrine"},{"key":"ref6","first-page":"637","article-title":"A survey on adrenal incidentaloma in Italy. Study Group on Adrenal Tumors of the\n                    Italian Society of Endocrinology","volume":"85","author":"F Mantero","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/bjs.7566","article-title":"Cohort study of patients with adrenal lesions discovered incidentally","volume":"98","author":"A Muth","year":"2011","journal-title":"Br J Surg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1001\/jamasurg.2015.1683","article-title":"Differences between bilateral adrenal incidentalomas and unilateral lesions","volume":"150","author":"J D Pasternak","year":"2015","journal-title":"JAMA Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10654-013-9771-5","article-title":"Twelve-year trends in the prevalence and risk factors of diabetes and\n                    prediabetes in Turkish adults","volume":"28","author":"I Satman","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"ref10","first-page":"1","article-title":"Prevalence of total, diagnosed, and undiagnosed diabetes among adults: United\n                    States, 2013-2016","author":"N D Mendola","year":"2018","journal-title":"NCHS Data Brief"},{"key":"ref11","first-page":"105","article-title":"Adrenal incidentalomas are tied to increased risk of diabetes: Findings from a\n                    prospective study","author":"G Reimondo","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejim.2011.08.009","article-title":"Traditional and novel cardiovascular risk factors in non-functioning adrenal\n                    adenomas","volume":"23","author":"S Yener","year":"2012","journal-title":"Eur J Intern Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/jc.2013-3527","article-title":"Long-term follow-up in adrenal incidentalomas: An Italian multicenter study","volume":"99","author":"V Morelli","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S2213-8587(22)00100-0","article-title":"Age-dependent and sex-dependent disparity in mortality in patients with adrenal\n                    incidentalomas and autonomous cortisol secretion: An international,\n                    retrospective, cohort study","volume":"10","author":"T Deutschbein","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/EJE-11-1039","article-title":"Progressively increased patterns of subclinical cortisol hypersecretion in\n                    adrenal incidentalomas differently predict major metabolic and cardiovascular\n                    outcomes: A large cross-sectional study","volume":"166","author":"G Di Dalmazi","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/jc.2010-2722","article-title":"Clinical review: Diagnosis and treatment of subclinical hypercortisolism","volume":"96","author":"I Chiodini","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF03346546","article-title":"Prospective evaluation of tumor size and hormonal status in adrenal\n                    incidentalomas","volume":"33","author":"S Yener","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/01.HYP.0000079505.25750.11","article-title":"Primary aldosteronism and hypertensive disease","volume":"42","author":"L Mosso","year":"2003","journal-title":"Hypertension"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/jch.13291","article-title":"Primary aldosteronism in patients with adrenal incidentaloma: Is screening\n                    appropriate for everyone?","volume":"20","author":"K Stavropoulos","year":"2018","journal-title":"J Clin Hypertens (Greenwich)"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2035-6091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T23:33:27Z","timestamp":1681428807000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2035-6091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":19,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,4,13]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2035-6091","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,14]]},"published":{"date-parts":[[2023,2,14]]}}}