{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:36:30Z","timestamp":1790876190398,"version":"4.1.0"},"reference-count":124,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["R21AR075997"],"award-info":[{"award-number":["R21AR075997"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01HL152108"],"award-info":[{"award-number":["R01HL152108"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["20TPA35410038"],"award-info":[{"award-number":["20TPA35410038"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Skeletal muscle is a highly plastic tissue that can alter its metabolic and\n                    contractile features, as well as regenerative potential in response to exercise\n                    and other conditions. Multiple signaling factors including metabolites, kinases,\n                    receptors, and transcriptional factors have been studied in the regulation of\n                    skeletal muscle plasticity. Recently, estrogen-related receptors (ERRs) have\n                    emerged as a critical transcriptional hub in control of skeletal muscle\n                    homeostasis. ERR\u03b1 and ERR\u03b3 \u2013 the two highly expressed\n                    ERR sub-types in the muscle respond to various extracellular cues such as\n                    exercise, hypoxia, fasting and dietary factors, in turn regulating gene\n                    expression in the skeletal muscle. On the other hand, conditions such as\n                    diabetes and muscular dystrophy suppress expression of ERRs in the skeletal\n                    muscle, likely contributing to disease progression. We highlight key functions\n                    of ERRs in the skeletal muscle including the regulation of fiber type,\n                    mitochondrial metabolism, vascularization, and regeneration. We also describe\n                    how ERRs are regulated in the skeletal muscle, and their interaction with\n                    important muscle regulators (e.\u2009g. AMPK and PGCs). Finally, we identify\n                    critical gaps in our understanding of ERR signaling in the skeletal muscle, and\n                    suggest future areas of investigation to advance ERRs as potential targets for\n                    function promoting therapeutics in muscle diseases.<\/jats:p>","DOI":"10.1055\/a-2035-8192","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:09:21Z","timestamp":1676419761000},"page":"609-617","source":"Crossref","is-referenced-by-count":15,"title":["Estrogen-related Receptor Signaling in Skeletal Muscle\n                    Fitness"],"prefix":"10.1055","volume":"44","author":[{"given":"Danesh","family":"Sopariwala","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, University of Texas John P and\n                    Katherine G McGovern Medical School, Houston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, University of Texas John P and\n                    Katherine G McGovern Medical School, Houston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vihang","family":"Narkar","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, University of Texas John P and\n                    Katherine G McGovern Medical School, Houston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e13086","DOI":"10.1111\/apha.13086","article-title":"Skeletal muscle in the fight against chronic diseases","volume":"223","author":"R Mrowka","year":"2018","journal-title":"Acta Physiol (Oxf)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1249\/MSS.0000000000000975","article-title":"Disease-induced skeletal muscle atrophy and fatigue","volume":"48","author":"S K Powers","year":"2016","journal-title":"Med Sci Sports Exerc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","article-title":"Fiber types in mammalian skeletal muscles","volume":"91","author":"S Schiaffino","year":"2011","journal-title":"Physiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41598-019-57110-6","article-title":"Single-cell transcriptional profiles in human skeletal muscle","volume":"10","author":"A B Rubenstein","year":"2020","journal-title":"Sci Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cmet.2012.12.012","article-title":"Exercise metabolism and the molecular regulation of skeletal muscle\n                    adaptation","volume":"17","author":"B Egan","year":"2013","journal-title":"Cell Metab"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.cmet.2018.04.014","article-title":"Maximizing cellular adaptation to endurance exercise in skeletal muscle","volume":"27","author":"J A Hawley","year":"2018","journal-title":"Cell Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"a029769","DOI":"10.1101\/cshperspect.a029769","article-title":"Adaptations to endurance and strength training","volume":"8","author":"D C Hughes","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.abb.2018.11.005","article-title":"Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A\n                    review of the causes and effects","volume":"662","author":"H Hyatt","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: aging-related loss of muscle mass and function","volume":"99","author":"L Larsson","year":"2019","journal-title":"Physiol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jcsm.12678","article-title":"Phenotypic features of cancer cachexia-related loss of skeletal muscle mass and\n                    function: lessons from human and animal studies","volume":"12","author":"A Martin","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref11","first-page":"94","article-title":"Muscle atrophy in patients with Type 2 Diabetes Mellitus: roles of inflammatory\n                    pathways, physical activity and exercise","volume":"22","author":"B D Perry","year":"2016","journal-title":"Exerc Immunol Rev"},{"key":"ref12","first-page":"157","article-title":"The role of mitochondria in Duchenne muscular dystrophy","volume":"72","author":"M Budzinska","year":"2021","journal-title":"J Physiol Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2044-5040-3-9","article-title":"Vascular-targeted therapies for Duchenne muscular dystrophy","volume":"3","author":"J P Ennen","year":"2013","journal-title":"Skelet Muscle"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"C288","DOI":"10.1152\/ajpcell.00188.2021","article-title":"Dystrophin deficiency disrupts muscle clock expression and mitochondrial quality\n                    control in mdx mice","volume":"321","author":"J P Hardee","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3389\/fphys.2020.00690","article-title":"Mitochondrial dysfunction is an early consequence of partial or complete\n                    dystrophin loss in mdx mice","volume":"11","author":"T M Moore","year":"2020","journal-title":"Front Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3390\/biomedicines9050481","article-title":"Age-dependent dysregulation of muscle vasculature and blood flow recovery after\n                    hindlimb ischemia in the mdx model of duchenne muscular dystrophy","volume":"9","author":"P Podkalicka","year":"2021","journal-title":"Biomedicines"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fphys.2014.00050","article-title":"Angiogenesis as a novel therapeutic strategy for Duchenne muscular dystrophy\n                    through decreased ischemia and increased satellite cells","volume":"5","author":"Y Shimizu-Motohashi","year":"2014","journal-title":"Front Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/MCO.0b013e32832a3d79","article-title":"Selective androgen receptor modulators as function promoting therapies","volume":"12","author":"S Bhasin","year":"2009","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1124\/pr.109.001560","article-title":"Regulation of skeletal muscle physiology and metabolism by peroxisome\n                    proliferator-activated receptor delta","volume":"61","author":"E Ehrenborg","year":"2009","journal-title":"Pharmacol Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00075197-200405000-00006","article-title":"Testosterone action on skeletal muscle","volume":"7","author":"K L Herbst","year":"2004","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"bqz017","DOI":"10.1210\/endocr\/bqz017","article-title":"The impact of skeletal muscle eralpha on mitochondrial function and metabolic\n                    health","volume":"161","author":"A L Hevener","year":"2020","journal-title":"Endocrinology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.afos.2016.06.002","article-title":"The role of sex steroid hormones in the pathophysiology and treatment of\n                    sarcopenia","volume":"2","author":"Y J Kim","year":"2016","journal-title":"Osteoporos Sarcopenia"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.biochi.2016.11.010","article-title":"Roles of Peroxisome Proliferator-Activated Receptor beta\/delta in\n                    skeletal muscle physiology","volume":"136","author":"R Manickam","year":"2017","journal-title":"Biochimie"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/331091a0","article-title":"Identification of a new class of steroid hormone receptors","volume":"331","author":"V Giguere","year":"1988","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.bbadis.2010.12.009","article-title":"Functional and physiological genomics of estrogen-related receptors (ERRs) in\n                    health and disease","volume":"1812","author":"G Deblois","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1210\/er.2008-0017","article-title":"Transcriptional control of energy homeostasis by the estrogen-related\n                    receptors","volume":"29","author":"V Giguere","year":"2008","journal-title":"Endocr Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2006.06.049","article-title":"Anatomical profiling of nuclear receptor expression reveals a hierarchical\n                    transcriptional network","volume":"126","author":"A L Bookout","year":"2006","journal-title":"Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2007.03.007","article-title":"Genome-wide orchestration of cardiac functions by the orphan nuclear receptors\n                    ERRalpha and gamma","volume":"5","author":"C R Dufour","year":"2007","journal-title":"Cell Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1021\/jm049334f","article-title":"Identification of a selective inverse agonist for the orphan nuclear receptor\n                    estrogen-related receptor alpha","volume":"47","author":"B B Busch","year":"2004","journal-title":"J Med Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.bmcl.2005.01.025","article-title":"Identification of an agonist ligand for estrogen-related receptors\n                    ERRbeta\/gamma","volume":"15","author":"D D Yu","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fendo.2019.00206","article-title":"ERRalpha as a bridge between transcription and function: Role in liver\n                    metabolism and disease","volume":"10","author":"H Xia","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1016\/j.celrep.2018.02.061","article-title":"ERRgamma preserves brown fat innate thermogenic activity","volume":"22","author":"M Ahmadian","year":"2018","journal-title":"Cell Rep"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.isci.2018.03.005","article-title":"Estrogen-related receptors mediate the adaptive response of brown adipose tissue\n                    to adrenergic stimulation","volume":"2","author":"E L Brown","year":"2018","journal-title":"iScience"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2007.06.007","article-title":"ERRgamma directs and maintains the transition to oxidative metabolism in the\n                    postnatal heart","volume":"6","author":"W A Alaynick","year":"2007","journal-title":"Cell Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/s41467-022-29733-3","article-title":"The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to\n                    orchestrate cardiomyocyte maturation","volume":"13","author":"T Sakamoto","year":"2022","journal-title":"Nat Commun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1161\/CIRCRESAHA.119.316100","article-title":"A Critical role for estrogen-related receptor signaling in cardiac\n                    maturation","volume":"126","author":"T Sakamoto","year":"2020","journal-title":"Circ Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1128\/MCB.01156-14","article-title":"Estrogen-related receptor alpha (ERRalpha) and ERRgamma are essential\n                    coordinators of cardiac metabolism and function","volume":"35","author":"T Wang","year":"2015","journal-title":"Mol Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e378","DOI":"10.1016\/j.cmet.2020.11.011","article-title":"Hurtado Del Pozo C et al. The nuclear receptor ESRRA protects from kidney\n                    disease by coupling metabolism and differentiation","volume":"33","author":"P Dhillon","year":"2021","journal-title":"Cell Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/15548627.2017.1339001","article-title":"ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional\n                    and post-translational activation of autophagy to promote innate host\n                    defense","volume":"14","author":"S Y Kim","year":"2018","journal-title":"Autophagy"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.immuni.2015.07.003","article-title":"Orphan nuclear receptor erralpha controls macrophage metabolic signaling and A20\n                    expression to negatively regulate TLR-induced inflammation","volume":"43","author":"J M Yuk","year":"2015","journal-title":"Immunity"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cmet.2011.01.019","article-title":"Exercise and PGC-1alpha-independent synchronization of type I muscle metabolism\n                    and vasculature by ERRgamma","volume":"13","author":"V A Narkar","year":"2011","journal-title":"Cell Metab"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"22619","DOI":"10.1074\/jbc.M110.125401","article-title":"Estrogen-related receptor gamma is a key regulator of muscle mitochondrial\n                    activity and oxidative capacity","volume":"285","author":"S M Rangwala","year":"2010","journal-title":"J Biol Chem"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1113\/jphysiol.2005.092031","article-title":"Mitofusins 1\/2 and ERRalpha expression are increased in human skeletal\n                    muscle after physical exercise","volume":"567","author":"R Cartoni","year":"2005","journal-title":"J Physiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1089\/ars.2012.4866","article-title":"Mitochondrial metabolic reprogramming induced by calorie restriction","volume":"19","author":"A Martin-Montalvo","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11010-009-0174-6","article-title":"Up-regulation of orphan nuclear estrogen-related receptor alpha expression\n                    during long-term caloric restriction in mice","volume":"332","author":"HS Ranhotra","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e21480","DOI":"10.1096\/fj.202001794RR","article-title":"Estrogen-related receptor alpha is involved in angiogenesis and skeletal muscle\n                    revascularization in hindlimb ischemia","volume":"35","author":"D H Sopariwala","year":"2021","journal-title":"FASEB J"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1161\/CIRCRESAHA.112.266478","article-title":"Revascularization of ischemic skeletal muscle by estrogen-related\n                    receptor-gamma","volume":"110","author":"A Matsakas","year":"2012","journal-title":"Circ Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"bqab112","DOI":"10.1210\/endocr\/bqab112","article-title":"Thyroid hormone receptor alpha regulates autophagy, mitochondrial biogenesis,\n                    and fatty acid use in skeletal muscle","volume":"162","author":"J Zhou","year":"2021","journal-title":"Endocrinology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1080\/21655979.2021.1948951","article-title":"Declined expressions of vast mitochondria-related genes represented by CYCS and\n                    transcription factor ESRRA in skeletal muscle aging","volume":"12","author":"J Kan","year":"2021","journal-title":"Bioengineered"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"E615","DOI":"10.1152\/ajpendo.00452.2013","article-title":"Activation of alternative NF-kappaB signaling during recovery of disuse-induced\n                    loss of muscle oxidative phenotype","volume":"306","author":"A H Remels","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-010-0677-1","article-title":"Mitochondrial adaptations in skeletal muscle to hindlimb unloading","volume":"350","author":"A Wagatsuma","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/hmg\/ddy405","article-title":"Dynamic transcriptomic analysis reveals suppression of\n                    PGC1alpha\/ERRalpha drives perturbed myogenesis in facioscapulohumeral\n                    muscular dystrophy","volume":"28","author":"CR S Banerji","year":"2019","journal-title":"Hum Mol Genet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"101157","DOI":"10.1016\/j.molmet.2020.101157","article-title":"Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for\n                    dystrophin and utrophin in adaptation and plasticity","volume":"45","author":"J P Hardee","year":"2021","journal-title":"Mol Metab"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1096\/fj.13-228296","article-title":"Muscle ERRgamma mitigates Duchenne muscular dystrophy via metabolic and\n                    angiogenic reprogramming","volume":"27","author":"A Matsakas","year":"2013","journal-title":"FASEB J"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.nbd.2012.08.015","article-title":"Disruption of skeletal muscle mitochondrial network genes and miRNAs in\n                    amyotrophic lateral sclerosis","volume":"49","author":"A P Russell","year":"2013","journal-title":"Neurobiol Dis"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"8068","DOI":"10.1096\/fj.201902399RR","article-title":"Undaria pinnatifida extract feeding increases exercise endurance and skeletal\n                    muscle mass by promoting oxidative muscle remodeling in mice","volume":"34","author":"J Ahn","year":"2020","journal-title":"FASEB J"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e2000652","DOI":"10.1002\/mnfr.202000652","article-title":"gamma-oryzanol improves exercise endurance and muscle strength by upregulating\n                    PPARdelta and ERRgamma activity in aged mice","volume":"65","author":"J Ahn","year":"2021","journal-title":"Mol Nutr Food Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1089\/jmf.2019.4485","article-title":"Standardized siegesbeckia orientalis l. extract increases exercise endurance\n                    through stimulation of mitochondrial biogenesis","volume":"22","author":"M B Kim","year":"2019","journal-title":"J Med Food"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"108315","DOI":"10.1016\/j.jnutbio.2019.108315","article-title":"Daidzein promotes the expression of oxidative phosphorylation- and fatty acid\n                    oxidation-related genes via an estrogen-related receptor alpha pathway to\n                    decrease lipid accumulation in muscle cells","volume":"77","author":"K Kitamura","year":"2020","journal-title":"J Nutr Biochem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1096\/fba.2022-00015","article-title":"Estrogen-related receptor alpha is an AMPK-regulated factor that promotes\n                    ischemic muscle revascularization and recovery in diet-induced obese mice","volume":"4","author":"D H Sopariwala","year":"2022","journal-title":"FASEB Bioadv"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1161\/HYPERTENSIONAHA.111.174128","article-title":"AMP activated protein kinase-alpha2 regulates expression of estrogen-related\n                    receptor-alpha, a metabolic transcription factor related to heart failure\n                    development","volume":"58","author":"X Hu","year":"2011","journal-title":"Hypertension"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/path.4329","article-title":"ERRalpha augments HIF-1 signalling by directly interacting with HIF-1alpha in\n                    normoxic and hypoxic prostate cancer cells","volume":"233","author":"C Zou","year":"2014","journal-title":"J Pathol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"881252","DOI":"10.3389\/fonc.2022.881252","article-title":"Role of HIF-1alpha\/ERRalpha in enhancing cancer cell metabolism and\n                    promoting resistance of endometrial cancer cells to pyroptosis","volume":"12","author":"P Su","year":"2022","journal-title":"Front Oncol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"18504","DOI":"10.1074\/jbc.M313543200","article-title":"A polymorphic autoregulatory hormone response element in the human\n                    estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome\n                    proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha\n                    expression","volume":"279","author":"J Laganiere","year":"2004","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mce.2006.11.002","article-title":"Interplay between estrogen-related receptor alpha (ERRalpha) and gamma\n                    (ERRgamma) on the regulation of ERRalpha gene expression","volume":"264","author":"Z Zhang","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.biopha.2018.02.096","article-title":"MiR-204-5p regulates C2C12 myoblast differentiation by targeting MEF2C and\n                    ERRgamma","volume":"101","author":"X Cheng","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.3892\/mmr.2014.3124","article-title":"Silencing miR-106b improves palmitic acid-induced mitochondrial dysfunction and\n                    insulin resistance in skeletal myocytes","volume":"11","author":"Y Zhang","year":"2015","journal-title":"Mol Med Rep"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.7150\/thno.44877","article-title":"A novel miR-1291-ERRalpha-CPT1C axis modulates tumor cell proliferation,\n                    metabolism and tumorigenesis","volume":"10","author":"Y Chen","year":"2020","journal-title":"Theranostics"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/jog.13560","article-title":"MiRNA-320a inhibits trophoblast cell invasion by targeting estrogen-related\n                    receptor-gamma","volume":"44","author":"T Gao","year":"2018","journal-title":"J Obstet Gynaecol Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/jcp.26842","article-title":"Regulatory role of microRNA-320a in the proliferation, migration, invasion, and\n                    apoptosis of trophoblasts and endothelial cells by targeting estrogen-related\n                    receptor gamma","volume":"234","author":"R H Liu","year":"2018","journal-title":"J Cell Physiol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"8735","DOI":"10.1038\/srep08735","article-title":"MicroRNA-320a sensitizes tamoxifen-resistant breast cancer cells to tamoxifen by\n                    targeting ARPP-19 and ERRgamma","volume":"5","author":"M Lu","year":"2015","journal-title":"Sci Rep"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/hmg\/ddq550","article-title":"Parkin degrades estrogen-related receptors to limit the expression of monoamine\n                    oxidases","volume":"20","author":"Y Ren","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1159\/000493713","article-title":"Parkin Modulates erralpha\/enos signaling pathway in endothelial\n                    cells","volume":"49","author":"W Xia","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"8499","DOI":"10.1038\/s41598-020-65438-7","article-title":"Nuclear parkin activates the erralpha transcriptional program and drives\n                    widespread changes in gene expression following hypoxia","volume":"10","author":"S E Shires","year":"2020","journal-title":"Sci Rep"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.canlet.2021.01.007","article-title":"FBXL10 promotes ERRalpha protein stability and proliferation of breast cancer\n                    cells by enhancing the mono-ubiquitylation of ERRalpha","volume":"502","author":"Y Yang","year":"2021","journal-title":"Cancer Lett"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1210\/me.2007-0357","article-title":"Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha\n                    and -gamma transcriptional activity through a synergy control motif","volume":"22","author":"A M Tremblay","year":"2008","journal-title":"Mol Endocrinol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"9795","DOI":"10.1021\/bi700316g","article-title":"Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1","volume":"46","author":"E H Vu","year":"2007","journal-title":"Biochemistry"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1210\/me.2009-0441","article-title":"An acetylation switch modulates the transcriptional activity of estrogen-related\n                    receptor alpha","volume":"24","author":"B J Wilson","year":"2010","journal-title":"Mol Endocrinol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1038\/s41467-022-29722-6","article-title":"Insulin action and resistance are dependent on a GSK3beta-FBXW7-ERRalpha\n                    transcriptional axis","volume":"13","author":"H Xia","year":"2022","journal-title":"Nat Commun"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.2337\/db15-1523","article-title":"O-GlcNAcylation of orphan nuclear receptor estrogen-related receptor gamma\n                    promotes hepatic gluconeogenesis","volume":"65","author":"J Misra","year":"2016","journal-title":"Diabetes"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/j.1742-4658.2006.05183.x","article-title":"Identification of ERRalpha as a specific partner of PGC-1alpha for the\n                    activation of PDK4 gene expression in muscle","volume":"273","author":"M Araki","year":"2006","journal-title":"FEBS J"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"9079","DOI":"10.1128\/MCB.24.20.9079-9091.2004","article-title":"Estrogen-related receptor alpha directs peroxisome proliferator-activated\n                    receptor alpha signaling in the transcriptional control of energy metabolism in\n                    cardiac and skeletal muscle","volume":"24","author":"J M Huss","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"10684","DOI":"10.1128\/MCB.25.24.10684-10694.2005","article-title":"PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor\n                    ERRalpha: A mechanism for transcriptional control of muscle glucose\n                    metabolism","volume":"25","author":"A R Wende","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1172\/JCI67652","article-title":"Nuclear receptor\/microRNA circuitry links muscle fiber type to energy\n                    metabolism","volume":"123","author":"Z Gan","year":"2013","journal-title":"J Clin Invest"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1096\/fj.13-229211","article-title":"Estrogen-related receptor-alpha (ERRalpha) deficiency in skeletal muscle impairs\n                    regeneration in response to injury","volume":"28","author":"S LaBarge","year":"2014","journal-title":"FASEB J"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1096\/fj.12-212290","article-title":"Impaired myogenesis in estrogen-related receptor gamma (ERRgamma)-deficient\n                    skeletal myocytes due to oxidative stress","volume":"27","author":"J Murray","year":"2013","journal-title":"FASEB J"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1210\/me.2014-1281","article-title":"Estrogen-related receptor-alpha coordinates transcriptional programs essential\n                    for exercise tolerance and muscle fitness","volume":"28","author":"M C Perry","year":"2014","journal-title":"Mol Endocrinol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"25207","DOI":"10.1074\/jbc.M113.489674","article-title":"Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and\n                    estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a\n                    tissue-specific regulator of oxidative capacity in skeletal muscle cells","volume":"288","author":"Y Cho","year":"2013","journal-title":"J Biol Chem"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1128\/MCB.17.9.5400","article-title":"The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional\n                    regulator of the human medium-chain acyl coenzyme A dehydrogenase gene","volume":"17","author":"R Sladek","year":"1997","journal-title":"Mol Cell Biol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s00125-021-05481-9","article-title":"Branched-chain amino acid metabolism is regulated by ERRalpha in primary human\n                    myotubes and is further impaired by glucose loading in type 2 diabetes","volume":"64","author":"RJ O Sjogren","year":"2021","journal-title":"Diabetologia"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.1073\/pnas.1212976110","article-title":"Skeletal muscle PGC-1alpha controls whole-body lactate homeostasis through\n                    estrogen-related receptor alpha-dependent activation of LDH B and repression of\n                    LDH A","volume":"110","author":"S Summermatter","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"25306","DOI":"10.1074\/jbc.M116.749424","article-title":"Exercise inducible lactate dehydrogenase b regulates mitochondrial function in\n                    skeletal muscle","volume":"291","author":"X Liang","year":"2016","journal-title":"J Biol Chem"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"130059","DOI":"10.1016\/j.bbagen.2021.130059","article-title":"Pro-angiogenic approach for skeletal muscle regeneration","volume":"1866","author":"J F Floriano","year":"2022","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1530\/VB-19-0008","article-title":"Metabolic regulation of exercise-induced angiogenesis","volume":"1","author":"T Gorski","year":"2019","journal-title":"Vasc Biol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10974-019-09520-2","article-title":"The role of the microcirculation in muscle function and plasticity","volume":"40","author":"P Hendrickse","year":"2019","journal-title":"J Muscle Res Cell Motil"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/j.celrep.2018.02.047","article-title":"ERRgamma promotes angiogenesis, mitochondrial biogenesis, and oxidative\n                    remodeling in PGC1alpha\/beta-deficient muscle","volume":"22","author":"W Fan","year":"2018","journal-title":"Cell Rep"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"21401","DOI":"10.1073\/pnas.0909131106","article-title":"The transcriptional coactivator PGC-1alpha mediates exercise-induced\n                    angiogenesis in skeletal muscle","volume":"106","author":"J Chinsomboon","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"e00411","DOI":"10.1128\/MCB.00411-18","article-title":"Loss of estrogen-related receptor alpha facilitates angiogenesis in endothelial\n                    cells","volume":"39","author":"N Likhite","year":"2019","journal-title":"Mol Cell Biol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"C630","DOI":"10.1152\/ajpcell.00033.2011","article-title":"Estrogen-related receptor alpha regulates skeletal myocyte differentiation via\n                    modulation of the ERK MAP kinase pathway","volume":"301","author":"J Murray","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1210\/en.2018-00115","article-title":"Divergent role of estrogen-related receptor alpha in lipid- and fasting-induced\n                    hepatic steatosis in mice","volume":"159","author":"W B'Chir","year":"2018","journal-title":"Endocrinology"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"26442","DOI":"10.1038\/srep26442","article-title":"Exercise-like effects by Estrogen-related receptor-gamma in muscle do not\n                    prevent insulin resistance in db\/db mice","volume":"6","author":"P M Badin","year":"2016","journal-title":"Sci Rep"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biochi.2016.12.011","article-title":"Coregulator-mediated control of skeletal muscle plasticity \u2013 A\n                    mini-review","volume":"136","author":"S Schnyder","year":"2017","journal-title":"Biochimie"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.gde.2008.07.018","article-title":"PGC-1 coactivators and skeletal muscle adaptations in health and disease","volume":"18","author":"Z Arany","year":"2008","journal-title":"Curr Opin Genet Dev"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.2012.06738.x","article-title":"Role of PGC-1alpha signaling in skeletal muscle health and disease","volume":"1271","author":"C Kang","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"18678","DOI":"10.1073\/pnas.1113813108","article-title":"Disorder-to-order transition underlies the structural basis for the assembly of\n                    a transcriptionally active PGC-1alpha\/ERRgamma complex","volume":"108","author":"S Devarakonda","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.1073\/pnas.0401401101","article-title":"Erralpha and Gabpa\/b specify PGC-1alpha-dependent oxidative\n                    phosphorylation gene expression that is altered in diabetic muscle","volume":"101","author":"V K Mootha","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"12378","DOI":"10.1073\/pnas.2135217100","article-title":"PPARgamma coactivator 1beta\/ERR ligand 1 is an ERR protein ligand, whose\n                    expression induces a high-energy expenditure and antagonizes obesity","volume":"100","author":"Y Kamei","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/gerona\/61.8.773","article-title":"PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD\n                    expression in skeletal muscle of senescence-accelerated mice","volume":"61","author":"R Rodriguez-Calvo","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.mito.2010.05.012","article-title":"PGC-1 beta-regulated mitochondrial biogenesis and function in myotubes is\n                    mediated by NRF-1 and ERR alpha","volume":"10","author":"D Shao","year":"2010","journal-title":"Mitochondrion"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.celrep.2013.04.023","article-title":"Disconnecting mitochondrial content from respiratory chain capacity in\n                    PGC-1-deficient skeletal muscle","volume":"3","author":"G C Rowe","year":"2013","journal-title":"Cell Rep"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cmet.2010.11.008","article-title":"Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from\n                    fiber type determination and insulin sensitivity","volume":"12","author":"C Zechner","year":"2010","journal-title":"Cell Metab"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1128\/MCB.00877-12","article-title":"The corepressor NCoR1 antagonizes PGC-1alpha and estrogen-related receptor alpha\n                    in the regulation of skeletal muscle function and oxidative metabolism","volume":"32","author":"J Perez-Schindler","year":"2012","journal-title":"Mol Cell Biol"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"21872","DOI":"10.1074\/jbc.M109.022749","article-title":"SIRT1 controls the transcription of the peroxisome proliferator-activated\n                    receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through\n                    the PGC-1alpha autoregulatory loop and interaction with MyoD","volume":"284","author":"R Amat","year":"2009","journal-title":"J Biol Chem"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"e1004490","DOI":"10.1371\/journal.pgen.1004490","article-title":"Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and\n                    ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy","volume":"10","author":"A Chalkiadaki","year":"2014","journal-title":"PLoS Genet"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"C66","DOI":"10.1152\/ajpcell.00357.2013","article-title":"Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse\n                    muscle together with enhanced activity of the SIRT1-PGC-1alpha axis","volume":"307","author":"V Ljubicic","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1038\/sj.emboj.7601633","article-title":"Metabolic control of muscle mitochondrial function and fatty acid oxidation\n                    through SIRT1\/PGC-1alpha","volume":"26","author":"Z Gerhart-Hines","year":"2007","journal-title":"EMBO J"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and\n                    SIRT1 activity","volume":"458","author":"C Canto","year":"2009","journal-title":"Nature"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"E493","DOI":"10.1152\/ajpendo.00122.2017","article-title":"SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of\n                    AMPK","volume":"313","author":"X Cui","year":"2017","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"e85636","DOI":"10.1371\/journal.pone.0085636","article-title":"Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3","volume":"9","author":"L Lin","year":"2014","journal-title":"PLoS One"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"771","DOI":"10.18632\/aging.100075","article-title":"Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in\n                    skeletal muscle","volume":"1","author":"O M Palacios","year":"2009","journal-title":"Aging (Albany NY)"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"25207","DOI":"10.1074\/jbc.M113.489674","article-title":"Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and\n                    estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a\n                    tissue-specific regulator of oxidative capacity in skeletal muscle cells","volume":"288","author":"Y Cho","year":"2013","journal-title":"J Biol Chem"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"18161","DOI":"10.1038\/s41598-021-97294-4","article-title":"Reduced mitochondrial fission and impaired energy metabolism in human primary\n                    skeletal muscle cells of Megaconial Congenital Muscular Dystrophy","volume":"11","author":"E Aksu-Menges","year":"2021","journal-title":"Sci Rep"},{"key":"ref123","first-page":"499","article-title":"Dysferlinopathy: mitochondrial abnormalities in human skeletal muscle","volume":"126","author":"F Liu","year":"2016","journal-title":"Int J Neurosci"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.mce.2009.07.012","article-title":"An ERRbeta\/gamma agonist modulates GRalpha expression, and\n                    glucocorticoid responsive gene expression in skeletal muscle cells","volume":"315","author":"S C Wang","year":"2010","journal-title":"Mol Cell Endocrinol"}],"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2035-8192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T22:58:19Z","timestamp":1690325899000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2035-8192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,14]]},"references-count":124,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2023,7,25]]},"published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2035-8192","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,14]]},"published":{"date-parts":[[2023,2,14]]}}}