{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:20Z","timestamp":1787004860672,"version":"build-2736575974"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and study aims\u2002Pancreatoscopy-guided electrohydraulic lithotripsy (EHL) has proven to be an effective first-line therapy in symptomatic chronic pancreatitis (CP) patients with obstructing pancreatic duct (PD) stones 1. However, long-term outcomes of endoscopic EHL remain unknown. The aim of the present study was to evaluate the long-term treatment effects of EHL as first-line therapy and to compare with those obtained in a historical cohort of patients who underwent extracorporeal shockwave lithotripsy (ESWL) as primary treatment.<\/jats:p>\n                  <jats:p>Patients and methods\u2002An observational retrospective single-center long-term follow-up study was performed including 19 consecutive patients who previously underwent endoscopic EHL compared to 18 patients who underwent ESWL followed by endoscopic retrograde pancreatography (ERP). The primary endpoint was long-term treatment success after EHL or ESWL defined as no recurrence of symptomatic intraductal stones confirmed on imaging. Secondary endpoints for the EHL-population included long-term clinical success (i.\u200ae., a similar or lower Izbicki Pain Score or reduction in opiate usage as compared to 6-month follow-up), quality of life (QoL), pancreatic function and hospital re-admission rate.<\/jats:p>\n                  <jats:p>Results\u2002In the EHL group, 37\u200a% of the patients developed recurrent symptomatic PD stones versus 61\u200a% in the ESWL group after a median follow-up of 35.0 and 76.5 months. Of the patients with recurrence, 71\u200a% versus 100\u200a% underwent a reintervention. Median time to recurrence was 12.0 versus 13.0 months. Clinical success sustained in 58\u200a% of the EHL patients. QoL was not significantly different compared with 6-month follow-up and baseline.<\/jats:p>\n                  <jats:p>Conclusions\u2002Also at long-term follow-up, endoscopic EHL as first-line treatment is moderately effective for symptomatic CP patients with treatment success rates that seems at least equally effective as ESWL.<\/jats:p>","DOI":"10.1055\/a-2035-8969","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T20:11:21Z","timestamp":1679688681000},"page":"E296-E304","source":"Crossref","is-referenced-by-count":9,"title":["Long-term outcomes of pancreatoscopy-guided electrohydraulic lithotripsy for the treatment of obstructive pancreatic duct stones"],"prefix":"10.1055","volume":"11","clinical-trial-number":[{"clinical-trial-number":"ntr6853","registry":"10.18810\/dutch-trial-register"}],"author":[{"given":"Florence E.M.","family":"de Rijk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Research and Development, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M.C.","family":"Stassen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Research and Development, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia E.","family":"van der Wiel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja A.","family":"Boermeester","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yama","family":"Issa","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinus A.","family":"Kempeneers","sequence":"additional","affiliation":[{"name":"Amsterdam UMC, location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Verdonk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St. Antonius Hospital, Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco J.","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Jan F.","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(20)31318-0","article-title":"Chronic pancreatitis","volume":"396","author":"G Beyer","year":"2020","journal-title":"Lancet (London, 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