{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:37:07Z","timestamp":1756463827902,"version":"3.37.3"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Sellar pathologies are frequently found on imaging performed to investigate headache. However, both headache and incidental sellar lesions are common. Hence, this study prospectively examined headache prevalence, phenotype, and severity in patients with sellar pathologies and the impact of transsphenoidal surgery on headache.<\/jats:p><jats:p>\n          Methods\u2003Patients undergoing transsphenoidal resection of sellar lesions were consecutively recruited. At baseline, participants were defined as having headache or not and headache phenotype was characterized using validated questionnaires. Headache severity was assessed at baseline and 6 months postoperatively using the Headache Impact Test-6 (HIT-6) and Migraine Disability Assessment Score (MIDAS). Tumor characteristics were defined using radiological, histological, and endocrine factors. Primary outcomes included baseline headache prevalence and severity and headache severity change at 6 months postoperatively. Correlation between headache and radiological, histological, and endocrine characteristics was also of interest.<\/jats:p><jats:p>\n          Results\u2003Sixty participants (62% female, 47.1\u2009\u00b1\u200918.6 years) were recruited. Sixty-three percent possessed baseline headache. HIT-6 scores were higher in patients with primary headache risk factors, including younger age (R2 \u2009=\u2009\u22120.417, p\u2009=\u20090.010), smoking history (63.31\u2009\u00b1\u20097.93 vs 54.44\u2009\u00b1\u20099.21, p\u2009=\u20090.0060), and family headache history (68.13\u2009\u00b1\u20097.01 vs 54.94\u2009\u00b1\u20099.11, p\u2009=\u20090.0030). Headaches were more common in patients with dural invasion (55.70\u2009\u00b1\u200912.14 vs 47.18\u2009\u00b1\u200910.15, p\u2009=\u20090.027) and sphenoid sinus invasion (58.87\u2009\u00b1\u20098.97 vs 51.29\u2009\u00b1\u200910.97, p\u2009=\u20090.007). Postoperative severity scores improved more with higher baseline headache severity (HIT-6: R2\u2009=\u2009\u22120.682, p\u2009&lt;\u20090.001, MIDAS: R2\u2009=\u2009\u22120.880, p\u2009&lt;\u20090.0010) and dural invasion (MIDAS: \u221253.00\u2009\u00b1\u200918.68 vs 12.00\u2009\u00b1\u200917.54, p\u2009=\u20090.0030).<\/jats:p><jats:p>\n          Conclusion\u2003Headaches in sellar disease are likely primary disorders triggered or exacerbated by sellar pathology. These may respond to surgery, particularly in patients with severe headache and dural invasion.<\/jats:p>","DOI":"10.1055\/a-2036-0652","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:21:50Z","timestamp":1676506910000},"page":"247-254","source":"Crossref","is-referenced-by-count":1,"title":["Headache in Patients with Sellar Disease: Clinicomorphological Predictors of Headache and the Outcome of Endoscopic Transsphenoidal Surgery"],"prefix":"10.1055","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6656-5229","authenticated-orcid":false,"given":"Maria","family":"Joseph","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, Australia"},{"name":"Department of Neurosurgery, John Hunter Hospital, Newcastle, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin P.","family":"Jonker","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St Vincent's Hospital, Sydney, Australia"},{"name":"Institute of Academic Surgery and Department of Neurosurgery, Royal Prince Alfred Hospital, Sydney, Australia"},{"name":"Brain and Mind Centre, University of Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Winder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St Vincent's Hospital, Sydney, Australia"},{"name":"St Vincent's Clinical School, Faculty of Medicine, UNSW, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Earls","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, Australia"},{"name":"Department of Anatomical Pathology, St Vincent's Hospital, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raewyn","family":"Campbell","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, Australia"},{"name":"Department of Otolaryngology Head and Neck Surgery, Royal Prince Alfred Hospital, Sydney, Australia"},{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry H.","family":"Kalish","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Concord General Hospital, University of Sydney, Sydney, Australia"},{"name":"Faculty of Medicine, University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Sacks","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, Australia"},{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Concord General Hospital, University of Sydney, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"McCormack","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School, Faculty of Medicine, UNSW, Sydney, Australia"},{"name":"Department of Endocrinology, St Vincent's Hospital, Sydney, Australia"},{"name":"Hormones and Cancer Group, Garvan Institute of Medical Research, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, Australia"},{"name":"Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1001\/archneur.61.5.721","article-title":"Pituitary volume and headache: size is not everything","volume":"61","author":"M J Levy","year":"2004","journal-title":"Arch Neurol"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1468-2982.2007.01288.x","article-title":"The global burden of headache: a documentation of headache prevalence and disability worldwide","volume":"27","author":"Lj Stovner","year":"2007","journal-title":"Cephalalgia"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1046\/j.1365-2265.1999.00748.x","article-title":"Incidentally discovered pituitary lesions: high frequency of macroadenomas and hormone-secreting adenomas - results of a prospective 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