{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:36:10Z","timestamp":1740137770369,"version":"3.37.3"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["# PJT 148716"],"award-info":[{"award-number":["# PJT 148716"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006095","name":"Southern and Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","award":["# 2015112"],"award-info":[{"award-number":["# 2015112"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n            Objective\u2003The SOX-PTS, Amin, and M\u00e9an models are three different clinical prediction scores stratifying the risk for postthrombotic syndrome (PTS) development in patients with acute deep vein thrombosis (DVT) of the lower limbs. Herein, we aimed to assess and compare these scores in the same cohort of patients.<\/jats:p><jats:p>\n            Methods\u2003We retrospectively applied the three scores in a cohort of 181 patients (196 limbs) who participated in the SAVER pilot trial for an acute DVT. Patients were stratified into PTS risk groups using positivity thresholds for high-risk patients as proposed in the derivation studies. All patients were assessed for PTS 6 months after index DVT using the Villalta scale. We calculated the predictive accuracy for PTS and area under receiver operating characteristic (AUROC) curve for each model.<\/jats:p><jats:p>\n            Results\u2003The M\u00e9an model was the most sensitive (sensitivity 87.7%; 95% confidence interval [CI]: 77.2\u201394.5) with the highest negative predictive value (87.5%; 95% CI: 76.8\u201394.4) for PTS. The SOX-PTS was the most specific score (specificity 97.5%; 95% CI: 92.7\u201399.5) with the highest positive predictive value (72.7%; 95% CI: 39.0\u201394.0). The SOX-PTS and M\u00e9an models performed well for PTS prediction (AUROC: 0.72; 95% CI: 0.65\u20130.80 and 0.74; 95% CI: 0.67\u20130.82), whereas the Amin model did not (AUROC: 0.58; 95% CI: 0.49\u20130.67).<\/jats:p><jats:p>\n            Conclusion\u2003Our data support that the SOX-PTS and M\u00e9an models have good accuracy to stratify the risk for PTS.<\/jats:p>","DOI":"10.1055\/a-2039-3388","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T23:45:47Z","timestamp":1677023147000},"page":"692-699","source":"Crossref","is-referenced-by-count":2,"title":["Performance and Head-to-Head Comparison of Three Clinical Models to Predict Occurrence of Postthrombotic Syndrome: A Validation Study"],"prefix":"10.1055","volume":"123","clinical-trial-number":[{"clinical-trial-number":"nct02679664","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Michelle","family":"Pradier","sequence":"additional","affiliation":[{"name":"Department of Medicine (Division of Hematology) and the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Rodger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, McGill University, Montr\u00e9al, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed","family":"Ghanima","sequence":"additional","affiliation":[{"name":"Department of Research, Ostfold Hospital Trust, Norway"},{"name":"Department of Haematology, Oslo University Hospital and University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, University of Western Ontario, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudeep","family":"Shivakumar","sequence":"additional","affiliation":[{"name":"Division of Hematology, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan R.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Medicine, McGill University and Division of Clinical Epidemiology, Lady Davis Institute, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-8099","authenticated-orcid":false,"given":"Per Morten","family":"Sandset","sequence":"additional","affiliation":[{"name":"Department of Haematology, Oslo University Hospital and University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive","family":"Kearon","sequence":"additional","affiliation":[{"name":"Department of Medicine (Division of Hematology) and the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjeeta","family":"Mallick","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-1245","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Delluc","sequence":"additional","affiliation":[{"name":"Department of Medicine (Division of Hematology) and the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1182\/asheducation-2016.1.413","article-title":"The post-thrombotic syndrome","volume":"2016","author":"S R Kahn","year":"2016","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"issue":"20","key":"ref2","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1182\/blood-2018-01-785956","article-title":"How I treat the postthrombotic syndrome","volume":"131","author":"A Rabinovich","year":"2018","journal-title":"Blood"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.7326\/0003-4819-126-6-199703150-00006","article-title":"Cost of long-term complications of deep venous thrombosis of the lower extremities: an analysis of a defined patient population in Sweden","volume":"126","author":"D Bergqvist","year":"1997","journal-title":"Ann Intern Med"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0190-9622(94)70134-2","article-title":"A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications","volume":"31","author":"T Phillips","year":"1994","journal-title":"J Am Acad Dermatol"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3390\/jcm9040923","article-title":"Prevention and management of the post-thrombotic syndrome","volume":"9","author":"I Makedonov","year":"2020","journal-title":"J Clin Med"},{"issue":"08","key":"ref6","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.amjmed.2011.02.033","article-title":"Long-term low-molecular-weight heparin and the post-thrombotic syndrome: a systematic review","volume":"124","author":"R D Hull","year":"2011","journal-title":"Am J Med"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jvir.2022.05.030","article-title":"Predictors of clinical outcomes of pharmacomechanical catheter-directed thrombolysis for acute iliofemoral deep vein thrombosis: analysis of a multicenter randomized trial","volume":"33","author":"S Thukral","year":"2022","journal-title":"J Vasc Interv Radiol"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1055\/s-0038-1655743","article-title":"Development and validation of a practical two-step prediction model and clinical risk score for post-thrombotic syndrome","volume":"118","author":"E E Amin","year":"2018","journal-title":"Thromb Haemost"},{"issue":"08","key":"ref9","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1055\/s-0038-1661392","article-title":"Derivation and validation of a prediction model for risk stratification of post-thrombotic syndrome in elderly patients with a first deep vein thrombosis","volume":"118","author":"M M\u00e9an","year":"2018","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/jth.13909","article-title":"Development of a clinical prediction model for the postthrombotic syndrome in a prospective cohort of patients with proximal deep vein thrombosis","volume":"16","author":"A Rabinovich","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/jth.15537","article-title":"Statins for venous event reduction in patients with venous thromboembolism: a multicenter randomized controlled pilot trial assessing feasibility","volume":"20","author":"A Delluc","year":"2022","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1111\/jth.14791","article-title":"External validation of the SOX-PTS score in a prospective multicenter trial of patients with proximal deep vein thrombosis","volume":"18","author":"A Rabinovich","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"e12796","DOI":"10.1002\/rth2.12796","article-title":"New and known predictors of the postthrombotic syndrome: a subanalysis of the ATTRACT trial","volume":"6","author":"F Rinfret","year":"2022","journal-title":"Res Pract Thromb Haemost"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.thromres.2022.04.003","article-title":"Development and validation of a clinical prediction model for post thrombotic syndrome following anticoagulant therapy for acute deep venous thrombosis","volume":"214","author":"J Zhang","year":"2022","journal-title":"Thromb Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"990788","DOI":"10.3389\/fcvm.2022.990788","article-title":"Machine learning-based prediction of the post-thrombotic syndrome: model development and validation study","volume":"9","author":"T Yu","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.thromres.2022.03.014","article-title":"Prevention of post-thrombotic syndrome with rosuvastatin: a multicenter randomized controlled pilot trial (SAVER)","volume":"213","author":"A Delluc","year":"2022","journal-title":"Thromb Res"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2039-3388.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T05:21:03Z","timestamp":1687584063000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2039-3388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,21]]},"references-count":16,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2023,6,23]]},"published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2039-3388","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"type":"print","value":"0340-6245"},{"type":"electronic","value":"2567-689X"}],"subject":[],"published-other":{"date-parts":[[2023,2,21]]},"published":{"date-parts":[[2023,2,21]]}}}