{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:26:30Z","timestamp":1792441590892,"version":"4.5.0"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Corneal ectasia comprises keratoconus, keratoglobus, pellucid marginal degeneration, and iatrogenic keratectasia. In all forms of corneal ectasia, there is a thinning of the cornea, usually accompanied by steepening of the cornea, leading to irregular astigmatism. Here, we provide an overview of histopathologic alterations of the various corneal ectasias. Furthermore, histologic changes after surgical procedures that are performed in severe cases of corneal ectasia, such as corneal cross-linking and penetrating keratoplasty (pKPL), as well as refractive surgical procedures that may lead to postsurgical ectasia are presented. In addition to a literature review, histopathologic archival material was reviewed and examined to illustrate the specific histologic changes.<\/jats:p>","DOI":"10.1055\/a-2040-8283","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T19:04:15Z","timestamp":1677092655000},"page":"803-809","source":"Crossref","is-referenced-by-count":1,"title":["Histopathological Changes in Corneal Ectasia"],"prefix":"10.1055","volume":"240","author":[{"given":"Louisa M.","family":"Bulirsch","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum Bonn, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin U.","family":"L\u00f6ffler","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum Bonn, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Holz","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum Bonn, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5943-7675","authenticated-orcid":false,"given":"Martina C.","family":"Herwig-Carl","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum Bonn, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.jcrs.2014.04.013","article-title":"Biomechanics of corneal ectasia and biomechanical treatments","volume":"40","author":"C J Roberts","year":"2014","journal-title":"J Cataract Refract Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"108347","DOI":"10.1016\/j.exer.2020.108347","article-title":"Ectatic diseases","volume":"202","author":"M Q Salom\u00e3o","year":"2021","journal-title":"Exp Eye 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