{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:14:38Z","timestamp":1790694878773,"version":"4.1.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"name":"Shanghai Sailing Program","award":["19YF1406500"],"award-info":[{"award-number":["19YF1406500"]}]},{"name":"Zhongshan Hospital Foundation","award":["2021ZSYQ03"],"award-info":[{"award-number":["2021ZSYQ03"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81900511"],"award-info":[{"award-number":["81900511"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n            Background\u2003The aim of this study was to identify the role of factor VIII (FVIII) in portal vein thrombosis (PVT) occurrence in cirrhotic patients with gastroesophageal variceal bleeding.<\/jats:p><jats:p>\n            Methods\u2003A total of 453 cirrhotic patients with gastroesophageal varices were enrolled. Computed tomography was performed at baseline and patients were divided into PVT and non-PVT groups (n\u2009=\u2009131 vs. 322). Individuals without PVT at baseline were followed up for the development of PVT. Time-dependent receiver operating characteristic analysis of FVIII for PVT development was performed. The Kaplan\u2013Meier methodology was used to analyze the predictive ability of FVIII for PVT incidence at 1 year.<\/jats:p><jats:p>\n            Results\u2003FVIII activity (177.00 vs. 153.70, p\u2009=\u20090.001) was significantly increased in the PVT group compared with the non-PVT group in cirrhotic patients with gastroesophageal varices. FVIII activity was positively correlated with the severity of PVT (161.50 vs. 171.07 vs. 187.05%, p\u2009=\u20090.001). Furthermore, FVIII activity (hazard ratio [HR]: 3.48, 95% confidence interval [CI]: 1.14\u201310.68, p\u2009=\u20090.029 in model 1; HR: 3.29, 95% CI: 1.03\u201310.51, p\u2009=\u20090.045 in model 2) was an independent risk factor of 1-year PVT development in patients without PVT at baseline, which was confirmed by two separate Cox regression analysis and competing risk models. Patients with elevated FVIII activity exhibit a higher incidence of PVT in the non-PVT group at 1 year (15.17 vs. 3.16%, p\u2009&lt;\u20090.001). The predictive value of FVIII remains significant in individuals who have never received splenectomy (14.76 vs. 3.04%, p\u2009=\u20090.002).<\/jats:p><jats:p>\n            Conclusion\u2003Elevated FVIII activity was potentially associated with the occurrence and the severity of PVT. It might be helpful to identify cirrhotic patients at risk of PVT.<\/jats:p>","DOI":"10.1055\/a-2052-9381","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:09:42Z","timestamp":1678752582000},"page":"714-722","source":"Crossref","is-referenced-by-count":7,"title":["Increased Factor VIII Activity Is Predictive of the Occurrence of Portal Vein Thrombosis in Cirrhosis"],"prefix":"10.1055","volume":"123","author":[{"given":"Siyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Fan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoquan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, P. R. China"},{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.27546","article-title":"Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study","volume":"61","author":"F Nery","year":"2015","journal-title":"Hepatology"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1055\/s-0038-1676981","article-title":"Incidence and recurrence of portal vein thrombosis in cirrhotic patients","volume":"119","author":"F Violi","year":"2019","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jhep.2021.04.029","article-title":"Current knowledge and management of portal vein thrombosis in cirrhosis","volume":"75","author":"M Senzolo","year":"2021","journal-title":"J 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Tripodi","year":"2010","journal-title":"Hepatology"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jhep.2017.07.002","article-title":"Gut-derived endotoxin stimulates factor VIII secretion from endothelial cells. implications for hypercoagulability in cirrhosis","volume":"67","author":"R Carnevale","year":"2017","journal-title":"J Hepatol"}],"container-title":["Thrombosis and 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