{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:19:21Z","timestamp":1790360361729,"version":"4.1.0"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Infants of diabetic mothers (IDM) are at higher risk of perinatal morbidities and glycemic instability, but the impact of maternal diabetes on neonatal and neurological short-term outcomes of neonates with hypoxic\u2013ischemic encephalopathy (HIE) remains poorly described. Our objective was to determine the impact of maternal diabetes on neonatal and neurological short-term outcomes following neonatal HIE.<\/jats:p><jats:p>\n            Study Design\u2003This was a retrospective single-center study including 102 term neonates with HIE who received therapeutic hypothermia (TH) treatment between 2013 and 2020. Multiple regression analysis was used to assess the relationship between the presence of maternal diabetes and short-term outcomes.<\/jats:p><jats:p>\n            Results\u2003Neonates with HIE and maternal diabetes exposure had a significantly lower gestational age at birth (38.6 vs. 39.7 weeks of gestation, p\u2009=\u20090.005) and a significantly higher mean birth weight (3,588\u2009\u00b1\u2009752 vs. 3,214\u2009\u00b1\u2009514\u2009g, p\u2009=\u20090.012). IDM with HIE were ventilated for longer duration (8 vs. 4 days, p\u2009=\u20090.0047) and had a longer neonatal intensive care unit (NICU) stay (18 vs. 11 days, p\u2009=\u20090.0483) as well as took longer time to reach full oral feed (15 vs. 7 days, p\u2009=\u20090.0432) compared with neonates of nondiabetic mother. Maternal diabetes was also associated with an increased risk of death or abnormal neurological examination at discharge in neonates with HIE (odds ratio: 6.41 [1.54\u201326.32]).<\/jats:p><jats:p>\n            Conclusion\u2003In neonates with HIE, maternal diabetes is associated with an increased risk of death or short-term neonatal morbidities, such as longer duration of ventilation, prolonged neonatal stay, greater need for tube feeding, and being discharged with an abnormal neurological examination. Strategies to prevent, reduce, or better control maternal diabetes during pregnancy should be prioritized to minimize complications after perinatal asphyxia.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2053-7904","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:28:15Z","timestamp":1678840095000},"page":"e1581-e1590","source":"Crossref","is-referenced-by-count":5,"special_numbering":"S","title":["Exposure to Maternal Diabetes during Pregnancy Is Associated with Aggravated Short-Term Neonatal and Neurological Outcomes following Perinatal Hypoxic\u2013Ischemic Encephalopathy"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3137-9397","authenticated-orcid":false,"given":"Nancy","family":"Laval","sequence":"additional","affiliation":[{"name":"CHU Ste-Justine Research Center, Montr\u00e9al, QC, Canada"},{"name":"Department of Neonatology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariane","family":"Paquette","sequence":"additional","affiliation":[{"name":"CHU Ste-Justine Research Center, Montr\u00e9al, QC, Canada"},{"name":"Department of Neonatology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Talsmat","sequence":"additional","affiliation":[{"name":"CHU Ste-Justine Research Center, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohdana","family":"Marandyuk","sequence":"additional","affiliation":[{"name":"CHU Ste-Justine Research Center, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Wintermark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Montr\u00e9al Children's Hospital, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Birca","sequence":"additional","affiliation":[{"name":"CHU Ste-Justine Research Center, Montr\u00e9al, QC, Canada"},{"name":"Division of Neurology, Department of Neurosciences and Paediatrics, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elana F","family":"Pinchefsky","sequence":"additional","affiliation":[{"name":"CHU Ste-Justine Research Center, Montr\u00e9al, QC, Canada"},{"name":"Division of Neurology, Department of Neurosciences and Paediatrics, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Tremblay","sequence":"additional","affiliation":[{"name":"CHU Ste-Justine Research Center, Montr\u00e9al, QC, Canada"},{"name":"Department of Neonatology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/GCO.0000000000000581","article-title":"Antepartum and intrapartum risk factors for neonatal hypoxic-ischemic encephalopathy: a systematic review with meta-analysis","volume":"31","author":"A C Rossi","year":"2019","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.clp.2009.07.011","article-title":"Hypoxic-ischemic encephalopathy in the term infant","volume":"36","author":"A Fatemi","year":"2009","journal-title":"Clin Perinatol"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood 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