{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:45:16Z","timestamp":1774683916849,"version":"3.50.1"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003We aimed at assessing the association between meconium-stained amniotic fluid (MSAF) and adverse maternal and neonatal outcomes in early-term versus late-term pregnancies.<\/jats:p><jats:p>\n            Study Design\u2003Early-term pregnancies (37\u201339 weeks of gestation) presented with MSAF were compared with late-term (40\u201342 weeks of gestation) pregnancies with MSAF. The groups were compared with respect to background characteristics, maternal outcomes, and neonatal outcomes. The composite neonatal outcome was the primary outcome of the study, and secondary outcomes included maternal and neonatal outcomes.<\/jats:p><jats:p>\n            Results\u2003The early-term group comprised 239 women, compared with 362 women in the late-term group. The primary outcome did not differ between groups. We found a higher prevalence of gestational diabetes (8.37 vs. 3%, p\u2009&lt;\u20090.05), a shorter second stage of labor (45.61\u2009\u00b1\u200954.67 vs. 65.82\u2009\u00b1\u200962.99\u2009minutes, p\u2009&lt;\u20090.05), and a longer hospital stay (2.84\u2009\u00b1\u20092.21 vs. 2.53\u2009\u00b1\u20091.26 days, p\u2009&lt;\u20090.05) in the early-term group. Other maternal and neonatal characteristics and outcomes were not significantly different between the two groups.<\/jats:p><jats:p>\n            Conclusion\u2003In term pregnancies complicated by MSAF, adverse neonatal and maternal delivery outcomes are equivalent, regardless of gestational age, and therefore, any term pregnancy complicated by MSAF should be considered high risk and managed appropriately.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2053-8018","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:28:15Z","timestamp":1678840095000},"page":"e1591-e1598","source":"Crossref","is-referenced-by-count":2,"special_numbering":"S","title":["Correlation of Meconium-Stained Amniotic Fluid and Adverse Pregnancy Outcomes between 37 to 39 and 40 to 42 Weeks of Gestational Age"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2684-0046","authenticated-orcid":false,"given":"Anat","family":"Lavie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shira","family":"Fisch","sequence":"additional","affiliation":[{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Reicher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel"},{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Zohav","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Maslovitz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"ref1","first-page":"150","article-title":"The composition of meconium\u202f: isolation of abnormal composition of meconium in meconium ileus alcohol","volume":"112","author":"S Rapoport"},{"issue":"04","key":"ref2","first-page":"201","article-title":"Use of maternal plasma level of zinc-coproporphyrin in the prediction of intrauterine passage of meconium: a pilot study","volume":"9","author":"I M Usta","year":"2000","journal-title":"J Matern Fetal Med"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0031-3955(05)70025-0","article-title":"Meconium-stained amniotic fluid and the meconium aspiration syndrome. An update","volume":"45","author":"G M Cleary","year":"1998","journal-title":"Pediatr Clin North Am"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0016-5085(76)80277-6","article-title":"Development of the human gastrointestinal tract. A review","volume":"70","author":"R J Grand","year":"1976","journal-title":"Gastroenterology"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0022-3476(55)80205-3","article-title":"The time of passage of the first stool and first urine by the newborn infant","volume":"46","author":"S N Sherry","year":"1955","journal-title":"J Pediatr"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/0144361021000020333","article-title":"The relative risk of 'fetal distress' in pregnancy associated with meconium-stained liquor at different gestation","volume":"22","author":"S F Wong","year":"2002","journal-title":"J Obstet Gynaecol"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1542\/peds.64.1.30","article-title":"Relevance of the gestational age distribution of meconium passage in utero","volume":"64","author":"T G Matthews","year":"1979","journal-title":"Pediatrics"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/sj.jp.7200521","article-title":"Significance of meconium-stained amniotic fluid in the preterm population","volume":"21","author":"H Scott","year":"2001","journal-title":"J Perinatol"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/AOG.0b013e3182117a26","article-title":"Maternal and fetal characteristics associated with meconium-stained amniotic fluid","volume":"117","author":"I Balchin","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/01.ogx.0000149659.89530.c2","article-title":"Meconium passage in utero: mechanisms, consequences, and management","volume":"60","author":"S N Ahanya","year":"2005","journal-title":"Obstet Gynecol Surv"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/jp.2008.162","article-title":"Meconium aspiration syndrome: historical aspects","volume":"28","author":"A A Fanaroff","year":"2008","journal-title":"J Perinatol"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1542\/peds.62.4.454","article-title":"Mechanical and chemical damage to lung tissue caused by meconium aspiration","volume":"62","author":"D C Tyler","year":"1978","journal-title":"Pediatrics"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1136\/fn.84.1.F1","article-title":"Meconium aspiration syndrome and extracorporeal membrane oxygenation","volume":"84","author":"P J Davis","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1542\/peds.2005-2215","article-title":"The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome","volume":"117","author":"P A Dargaville","year":"2006","journal-title":"Pediatrics"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"F328","DOI":"10.1136\/adc.2002.021949","article-title":"Preterm meconium staining of the amniotic fluid: associated findings and risk of adverse clinical outcome","volume":"89","author":"A T Tybulewicz","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"17","key":"ref16","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1080\/14767058.2016.1236246","article-title":"Preterm meconium-stained amniotic fluid is an ominous sign for the development of chorioamnionitis and for in utero cord compression","volume":"30","author":"D Brabbing-Goldstein","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0301-2115(98)00141-9","article-title":"Meconium stained amniotic fluid in preterm delivery is an independent risk factor for perinatal complications","volume":"81","author":"M Mazor","year":"1998","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0029-7844(97)00308-6","article-title":"Meconium-stained amniotic fluid and risk for cerebral palsy in preterm infants","volume":"90","author":"A Spinillo","year":"1997","journal-title":"Obstet Gynecol"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/sj.jp.7211435","article-title":"The in utero passage of meconium by very low birth weight infants: a marker for adverse outcomes","volume":"26","author":"J A Henry","year":"2006","journal-title":"J Perinatol"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1080\/jmf.11.1.54.59","article-title":"The effect of meconium on perinatal outcome: a prospective analysis","volume":"11","author":"E Sheiner","year":"2002","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1067\/S0002-9378(03)00767-1","article-title":"Meconium-stained amniotic fluid is associated with puerperal infections","volume":"189","author":"S H Tran","year":"2003","journal-title":"Am J Obstet Gynecol"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1365-3016.2007.00875.x","article-title":"Severe respiratory disorders in term neonates","volume":"22","author":"J B Gouyon","year":"2008","journal-title":"Paediatr Perinat Epidemiol"},{"issue":"02","key":"ref23","first-page":"175","article-title":"Meconium in the amniotic fluid and fetal acid-base status","volume":"73","author":"E R Yeomans","year":"1989","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/15513815.2012.659384","article-title":"Meconium-stained amniotic fluid and hypoglycemia among term newborn infants","volume":"31","author":"A Maayan-Metzger","year":"2012","journal-title":"Fetal Pediatr Pathol"},{"issue":"03","key":"ref25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pedneo.2013.01.001","article-title":"Prognostic factors of developmental outcome in neonatal seizures in term infants","volume":"54","author":"Y-H Lai","year":"2013","journal-title":"Pediatr Neonatol"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1471-0528.1954.tb07463.x","article-title":"Foetal anoxia; a clinical and laboratory study","volume":"61","author":"J Walker","year":"1954","journal-title":"J Obstet Gynaecol Br Emp"},{"key":"ref27","first-page":"869","article-title":"Amniography studies of the gastrointetinal motility of the fetus","author":"R Clarenc","year":"1963","journal-title":"Physiol Pregnancy Labor Puerperium"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/0022-3468(94)90152-X","article-title":"In utero defecation of the nondistressed fetus: a roentgen study in the goat","volume":"29","author":"F Kizilcan","year":"1994","journal-title":"J Pediatr Surg"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S0022-3468(96)90841-6","article-title":"In utero defecation by the normal fetus: a radionuclide study in the rabbit","volume":"31","author":"A O Ciftci","year":"1996","journal-title":"J Pediatr Surg"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0022-3468(99)90183-5","article-title":"Fetal distress does not affect in utero defecation but does impair the clearance of amniotic fluid","volume":"34","author":"A O Ciftci","year":"1999","journal-title":"J Pediatr Surg"},{"issue":"02","key":"ref31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/01.AOG.0000226853.85609.8d","article-title":"Meconium-stained amniotic fluid across gestation and neonatal acid-base status","volume":"108","author":"Y Oyelese","year":"2006","journal-title":"Obstet Gynecol"},{"issue":"13","key":"ref32","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3109\/14767058.2013.858320","article-title":"New onset of meconium during labor versus primary meconium-stained amniotic fluid---is there a difference in pregnancy outcome?","volume":"27","author":"L Hiersch","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"03","key":"ref33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00431-016-2845-0","article-title":"A study of oxidative stress in neonates delivered through meconium-stained amniotic fluid","volume":"176","author":"T Bandyopadhyay","year":"2017","journal-title":"Eur J Pediatr"},{"key":"ref34","first-page":"R485","article-title":"Fetal iron and cytochrome c status after intrauterine hypoxemia and erythropoietin administration","volume":"262","author":"M K Georgieff","year":"1992","journal-title":"Am J Physiol"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0002-9378(00)20815-6","article-title":"Fetal erythropoietin levels in pregnancies complicated by meconium passage: does meconium suggest fetal hypoxia?","volume":"183","author":"A Jazayeri","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref36","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00404-008-0627-2","article-title":"A long-standing incomprehensible matter of obstetrics: meconium-stained amniotic fluid, a new approach to reason","volume":"278","author":"A Simsek","year":"2008","journal-title":"Arch Gynecol Obstet"},{"issue":"02","key":"ref37","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1097\/AOG.0000000000002501","article-title":"ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus","volume":"131","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref39","doi-asserted-by":"crossref","first-page":"369.e1","DOI":"10.1016\/j.ajog.2020.01.002","article-title":"Health resource utilization of labor induction versus expectant management","volume":"222","author":"W A Grobman","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"09","key":"ref40","first-page":"711","article-title":"Neonatal outcome in meconium stained amniotic fluid-one year experience","volume":"60","author":"E M Shaikh","year":"2010","journal-title":"J Pak Med Assoc"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/0002-9378(91)90707-X","article-title":"Progress in pathogenesis and management of clinical intraamniotic infection","volume":"164","author":"R S Gibbs","year":"1991","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"ref42","first-page":"1154","article-title":"Origins of cerebral palsy","volume":"143","author":"R L Naeye","year":"1989","journal-title":"Am J Dis Child"},{"issue":"03","key":"ref43","doi-asserted-by":"crossref","first-page":"283.e1","DOI":"10.1016\/j.ajog.2008.08.043","article-title":"Abnormal fetal heart rate tracing patterns in patients with thick meconium staining of the amniotic fluid: association with perinatal outcomes","volume":"200","author":"H Xu","year":"2009","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2053-8018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:27:52Z","timestamp":1730813272000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2053-8018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,14]]},"references-count":42,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2053-8018","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,14]]},"published":{"date-parts":[[2023,3,14]]}}}