{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T18:23:51Z","timestamp":1786818231315,"version":"build-2736575974"},"reference-count":100,"publisher":"Georg Thieme Verlag KG","issue":"07\/08","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The initial isolation of adrenal steroids from large quantities of animal\n                    adrenals resulted in an amorphous fraction resistant to crystallization and\n                    identification and had potent effects on electrolyte transport. Aldosterone was\n                    eventually isolated and identified in the fraction and was soon shown to cause\n                    hypertension when in excess. The autonomous and excessive production of\n                    aldosterone, primary aldosteronism, is the most common cause of secondary\n                    hypertension. Aldosterone is metabolized in the liver and kidney, and its\n                    metabolites are conjugated with glucuronic acid for excretion. The most common\n                    liver metabolite is 3\u03b1,5\u03b2-tetrahydroaldosterone-3-glucuronide,\n                    while that of the kidney is aldosterone-18-oxo-glucuronide. In terms of their\n                    value, especially the aldosterone-18-oxo-glucuronide, is commonly used for the\n                    diagnosis of primary aldosteronism because they provide an integrated value of\n                    the total daily production of aldosterone. Conversion of aldosterone to\n                    18-oxo-glucuronide is impeded by drugs, like some common non-steroidal\n                    anti-inflammatory drugs that compete for UDP-glucuronosyltransferase-2B7, the\n                    most important glucuronosyltransferase for aldosterone metabolism.\n                    Tetrahydroaldosterone is the most abundant metabolite and the most reliable for\n                    the diagnosis of primary aldosteronism, but it is not commonly measured.<\/jats:p>","DOI":"10.1055\/a-2054-1062","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:30:45Z","timestamp":1678840245000},"page":"386-393","source":"Crossref","is-referenced-by-count":9,"title":["An Abbreviated History of Aldosterone Metabolism, Current and Future\n                    Challenges"],"prefix":"10.1055","volume":"131","author":[{"given":"Celso E","family":"Gomez-Sanchez","sequence":"additional","affiliation":[{"name":"G.V. (Sonny) Montgomery VA Medical Center and Department of\n                    Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson,\n                    MS, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise P","family":"Gomez-Sanchez","sequence":"additional","affiliation":[{"name":"G.V. (Sonny) Montgomery VA Medical Center and Department of\n                    Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson,\n                    MS, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1210\/endrev\/bnac019","article-title":"History of adrenal research: From ancient anatomy to contemporary molecular\n                    biology","volume":"44","author":"W L Miller","year":"2023","journal-title":"Endocr Rev"},{"key":"ref2","first-page":"517","article-title":"Chronics suprarenal insufficiency, usually due to tuberculosis of suprarenal\n                    capsule. 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