{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:22:18Z","timestamp":1784326938177,"version":"3.55.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Suppression of TSH levels associated with levothyroxine treatment is a known risk\n                    factor for fracture. However, it is unclear whether patients with papillary\n                    thyroid carcinoma (PTC) have a higher risk of vertebral fracture (VF) before TSH\n                    suppression. The aim of the study was to examine whether the risk of VF is\n                    higher in PTC than in healthy subjects. A hospital-based, matched case-control\n                    study was conducted comparing PTC and healthy individuals. We enrolled 43\n                    postoperative patients with PTC scheduled for radioiodine therapy and 43 age-\n                    and sex-matched healthy controls. Serum and urinary biological parameters, bone\n                    mineral density (BMD), and presence of VFs were evaluated in both groups. We\n                    compared these indices using \u03c72 and Mann\u2013Whitney U-test and\n                    analyzed the association between PTC and VF by logistic regression analysis. The\n                    PTC group had higher BMI, HbA1c and phosphorus, and lower intact PTH than the\n                    control group. Lumbar and femoral neck BMD did not differ between the two\n                    groups. Prevalence of VFs was significantly higher in the PTC group\n                    (44.1%) than in the control group (16.3%). Multivariate logistic\n                    regression analyses adjusted for age, sex, and BMI identified PTC as being\n                    associated with the presence of VFs (odds ratio, 5.63; 95% confidence\n                    interval: 1.82 to 17.5). This relationship remained significant after additional\n                    adjustment for HbA1c and BMD. There is an association between PTC and a risk of\n                    VF independent of sex, BMI, glucose metabolism, and BMD, suggesting the\n                    importance of fracture risk assessment before TSH suppression.<\/jats:p>","DOI":"10.1055\/a-2059-8830","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T22:51:40Z","timestamp":1681771900000},"page":"592-598","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Papillary Thyroid Carcinoma and Vertebral\n                    Fracture"],"prefix":"10.1055","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-216X","authenticated-orcid":false,"given":"Hazuki","family":"Otani","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Izumo,\n                    Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8326-8154","authenticated-orcid":false,"given":"Masakazu","family":"Notsu","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Izumo,\n                    Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Research Institute for Metabolic Bone Diseases, Eikokai Ono Hospital,\n                    Ono, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoko","family":"Nawata","sequence":"additional","affiliation":[{"name":"Health and Nutrition, The University of Shimane, Izumo,\n                    Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Kanasaki","sequence":"additional","affiliation":[{"name":"Internal Medicine 1, Shimane University Faculty of Medicine, Izumo,\n                    Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1359\/JBMR.050711","article-title":"Relationship between osteoporosis and cardiovascular disease in postmenopausal\n                    women","volume":"20","author":"L B Tank\u00f3","year":"2005","journal-title":"J Bone Miner Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/jbmr.1755","article-title":"Cost-effectiveness of alendronate for the treatment of osteopenic postmenopausal\n                    women in Japan","volume":"28","author":"K Moriwaki","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/ijc.29251","article-title":"Thyroid cancer mortality and incidence: a global overview","volume":"136","author":"C La 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Liu","year":"2010","journal-title":"JBMR"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.mce.2009.10.003","article-title":"Thyroid cancer and inflammation","volume":"321","author":"V Guarino","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1365-2265.2009.03699.x","article-title":"The tight relationship between papillary thyroid cancer, autoimmunity and\n                    inflammation: clinical and molecular studies","volume":"72","author":"M Muzza","year":"2010","journal-title":"Clin Endocrinol"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2059-8830.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T23:16:08Z","timestamp":1694128568000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2059-8830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":30,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2023,9,7]]},"published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2059-8830","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]}}}