{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:42:19Z","timestamp":1792172539603,"version":"4.4.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Breast cancer is the most common cancer in women worldwide.\n                    Premature menopause and hot flashes are the main complications of breast cancer\n                    treatments. About 40 to 50 percent of breast cancer women who undergo\n                    chemotherapy are experiencing premature menopause symptoms, including hot\n                    flashes. Some endocrine therapies such as tamoxifen and aromatase inhibitors are\n                    associated with induction or aggravating hot flashes. Hot flashes are often\n                    debilitating and significantly impair daily functions. Therefore many\n                    therapeutic options have been studied so far for the management of this adverse\n                    effect. However, there are still some clinical challenges in managing hot\n                    flashes in patients with breast cancer.<\/jats:p><jats:p>\n          Objective We aimed to evaluate and compare the efficacy of venlafaxine and\n                    citalopram on hot flashes in breast cancer women receiving tamoxifen.<\/jats:p><jats:p>\n          Design We conducted a double-blind, placebo-controlled trial in forty-one,\n                    35 to 65 years old female patients. The study lasted for four weeks, and the\n                    follow-up was for two months. Venlafaxine and citalopram treatments started with\n                    doses of 37.5\u2009mg or 10\u2009mg, respectively. Venlafaxine and\n                    citalopram dosages were increased in the second week to 75 and 20\u2009mg,\n                    respectively. The study was conducted during the year 2017.<\/jats:p><jats:p>\n          Key Results The results indicated that the total efficacy was\n                    significantly different in groups receiving citalopram, venlafaxine, and\n                    placebo. Total efficacy in the placebo group, venlafaxine, and citalopram was\n                    14.3, 53.8, and 64.3%, respectively (p=0.02). During the second\n                    week, the efficacy in groups receiving citalopram, venlafaxine, and placebo was\n                    57.1, 53.8, and 14.3%, respectively (p=0.04). Generally, both\n                    citalopram and venlafaxine were well tolerated. The associated adverse effects\n                    were mild to moderate in both groups.<\/jats:p><jats:p>\n          Conclusions Although citalopram was associated with more adverse effects,\n                    including constipation, it was more effective in reducing the frequency of hot\n                    flashes when compared to venlafaxine or placebo.<\/jats:p>","DOI":"10.1055\/a-2061-7020","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T22:53:47Z","timestamp":1693436027000},"page":"465-472","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation and Comparison of Citalopram and Venlafaxine for\n                    Management of Hot Flashes in Women with Breast Cancer"],"prefix":"10.1055","volume":"73","author":[{"given":"Sasan Yaghoobi","family":"Taleghani","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran,\n                    Iran"},{"name":"Department of Clinical Hematology Oncology and Bone Marrow\n                    Transplantation, Imam Khomeini Hospital Complex, Tehran University of Medical\n                    Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Etesam","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychosomatic Research Center, Imam Khomeini\n                    Hospital Complex, Tehran University of Medical Sciences, Tehran,\n                    Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Esfandbod","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology Oncology and Bone Marrow\n                    Transplantation, Imam Khomeini Hospital Complex, Tehran University of Medical\n                    Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"ref4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10549-015-3465-5","article-title":"Venlafaxine in management of hot flashes in women with breast cancer: a\n                    systematic review and meta-analysis","volume":"152","author":"R Ramaswami","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1634\/theoncologist.2011-0174","article-title":"Hot flashes: a review of pathophysiology and treatment modalities","volume":"16","author":"P K Morrow","year":"2011","journal-title":"Oncologist"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-3-319-16366-6_9","article-title":"Symptoms: Menopause, Infertility, and Sexual Health","volume":"862","author":"D L Barton","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3322\/caac.21171","article-title":"Risk factors, pathophysiology, and treatment of hot flashes in cancer","volume":"63","author":"W I Fisher","year":"2013","journal-title":"CA Cancer J Clin"},{"key":"ref8","first-page":"123","article-title":"Management of menopause-associated vasomotor symptoms: Current treatment\n                    options, challenges and future directions","volume":"2","author":"D R Pachman","year":"2010","journal-title":"Int J Womens Health"},{"key":"ref9","first-page":"315","article-title":"Pathophysiology and management of hot flashes","volume":"4","author":"S Dalal","year":"2006","journal-title":"J Support Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/da.20085","article-title":"Venlafaxine in the treatment of depressive and vasomotor symptoms in women with\n                    perimenopausal depression","volume":"22","author":"C O Ladd","year":"2005","journal-title":"Depress Anxiety"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2165\/00002512-200118080-00004","article-title":"Hot flashes: aetiology and management","volume":"18","author":"D Barton","year":"2001","journal-title":"Drugs Aging"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1200\/JCO.2008.19.6253","article-title":"Newer antidepressants and gabapentin for hot flashes: an individual patient\n                    pooled analysis","volume":"27","author":"C L Loprinzi","year":"2009","journal-title":"J Clin Oncol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"zsx190","DOI":"10.1093\/sleep\/zsx190","article-title":"Effects of Pharmacologic and Nonpharmacologic Interventions on Insomnia Symptoms\n                    and Self-reported Sleep Quality in Women With Hot Flashes: A Pooled Analysis of\n                    Individual Participant Data From Four MsFLASH Trials","volume":"41","author":"K A Guthrie","year":"2018","journal-title":"Sleep."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1188\/14.CJON.S3.59-67","article-title":"Hot flash management: update of the evidence for patients with cancer","volume":"18","author":"M Kaplan","year":"2014","journal-title":"Clin J Oncol Nurs"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s12282-015-0655-2","article-title":"The pharmacological and hormonal therapy of hot flushes in breast cancer\n                    survivors","volume":"23","author":"I Wi\u015bniewska","year":"2016","journal-title":"Breast Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"460","DOI":"10.29271\/jcpsp.2018.06.460","article-title":"Managing Hot Flushes in Menopausal Women: A Review","volume":"28","author":"T H Mallhi","year":"2018","journal-title":"J Coll Physicians Surg 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Pract"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/annonc\/mdl478","article-title":"Venlafaxine is superior to clonidine as treatment of hot flashes in breast\n                    cancer patients \u2013 a double-blind, randomized study","volume":"18","author":"S Loibl","year":"2007","journal-title":"Ann Oncol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.6004\/jnccn.2010.0086","article-title":"Nonhormonal management of hot flashes for women on risk reduction therapy","volume":"8","author":"K Sideras","year":"2010","journal-title":"J Natl Compr Canc Netw"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ctrv.2016.11.012","article-title":"Management of hot flashes in women with breast cancer receiving ovarian function\n                    suppression","volume":"52","author":"R A Leon-Ferre","year":"2017","journal-title":"Cancer Treat Rev"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.mayocp.2016.04.009","article-title":"Management of Hormone Deprivation Symptoms After Cancer","volume":"91","author":"S S Faubion","year":"2016","journal-title":"Mayo Clin Proc"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.clinthera.2007.02.006","article-title":"Therapeutic options for the management of hot flashes in breast cancer\n                    survivors: an evidence-based review","volume":"29","author":"L Bordeleau","year":"2007","journal-title":"Clin Ther"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1080\/13697137.2019.1600501","article-title":"Managing vasomotor symptoms in women after cancer","volume":"22","author":"J V Pinkerton","year":"2019","journal-title":"Climacteric."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/GME.0000000000000449","article-title":"Antidepressants decrease hot flashes and improve life quality","volume":"22","author":"K J Ruddy","year":"2015","journal-title":"Menopause."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/GME.0000000000000364","article-title":"Effects of estrogen and venlafaxine on menopause-related quality of life in\n                    healthy postmenopausal women with hot flashes: a placebo-controlled randomized\n                    trial","volume":"22","author":"B Caan","year":"2015","journal-title":"Menopause."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s11606-013-2535-9","article-title":"SSRIs for hot flashes: a systematic review and meta-analysis of randomized\n                    trials","volume":"29","author":"T Shams","year":"2014","journal-title":"J Gen Intern Med"},{"key":"ref29","first-page":"272","article-title":"Do SSRIs and SNRIs reduce the frequency and\/or severity of hot flashes\n                    in menopausal women","volume":"110","author":"C Stubbs","year":"2017","journal-title":"J Okla State Med Assoc"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4314\/ejhs.v24i3.4","article-title":"Is desvenlafaxine effective and safe in the treatment of menopausal vasomotor\n                    symptoms? A meta-analysis and meta-regression of randomized double-blind\n                    controlled studies","volume":"24","author":"Y Berhan","year":"2014","journal-title":"Ethiop J Health Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.4067\/S0034-98872016001000013","article-title":"Elecci\u00f3n del mejor antidepresivo en pacientes con c\u00e1ncer de mama\n                    en tratamiento con tamoxifeno: revisi\u00f3n de la evidencia b\u00e1sica y\n                    cl\u00ednica [Antidepressants agents in breast cancer patients using\n                    tamoxifen: review of basic and clinical evidence]","volume":"144","author":"OM E Irarr\u00e1zaval","year":"2016","journal-title":"Rev Med Chil"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.4088\/JCP.08r04856blu","article-title":"Interactions between tamoxifen and antidepressants via cytochrome P450 2D6","volume":"70","author":"J E Desmarais","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"570","DOI":"10.2174\/138920011795713706","article-title":"Metabolic drug interactions between antidepressants and anticancer drugs: focus\n                    on selective serotonin reuptake inhibitors and hypericum extract","volume":"12","author":"F Caraci","year":"2011","journal-title":"Curr Drug Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1200\/JCO.2010.33.1298","article-title":"Management of hot flashes in patients who have breast cancer with venlafaxine\n                    and clonidine: a randomized, double-blind, placebo-controlled trial","volume":"29","author":"A H Boekhout","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00404-015-3900-1","article-title":"Comparison of citalopram and venlafaxine\u2019s role in treating sleep\n                    disturbances in menopausal women, a randomized, double-blind, placebo-controlled\n                    trial","volume":"293","author":"F Davari-Tanha","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"ref36","first-page":"47","article-title":"Pilot evaluation of citalopram for the relief of hot flashes","volume":"1","author":"D L Barton","year":"2003","journal-title":"J Support Oncol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/da.20085","article-title":"Venlafaxine in the treatment of depressive and vasomotor symptoms in women with\n                    perimenopausal depression","volume":"22","author":"C O Ladd","year":"2005","journal-title":"Depress Anxiety"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.maturitas.2005.01.001","article-title":"Evaluation of low-dose venlafaxine hydrochloride for the therapy of hot flushes\n                    in breast cancer survivors","volume":"52","author":"N Biglia","year":"2005","journal-title":"Maturitas."},{"key":"ref39","first-page":"173","article-title":"The Efficacy and Safety of Selective Serotonin Reuptake Inhibitors and\n                    Serotonin-Norepinephrine Reuptake Inhibitors in the Treatment of Menopausal Hot\n                    Flashes: A Systematic Review of Clinical Trials","volume":"47","author":"M Azizi","year":"2022","journal-title":"Iran J Med Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00520-013-1732-8","article-title":"Comit\u00e9 de l\u2019\u00e9volution des pratiques en oncologie (CEPO).\n                    Pharmacological and non-hormonal treatment of hot flashes in breast cancer\n                    survivors: CEPO review and recommendations","volume":"21","author":"S L\u2019Esp\u00e9rance","year":"2013","journal-title":"Support Care Cancer"}],"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2061-7020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T23:22:57Z","timestamp":1695770577000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2061-7020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":37,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2023,9,26]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2061-7020","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,30]]}}}