{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:53:20Z","timestamp":1787507600443,"version":"build-2736575974"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The need for clinical remedies to the multiple age-related deficiencies in skin\n                    function brought on by extrinsic and intrinsic causes is increased by these\n                    demographic changes. Reactive oxygen species (ROS), mitochondrial\n                    deoxyribonucleic acid (mtDNA) mutations, telomere shortening, as well as other\n                    factors, contribute to the aging of the skin. In this overview, the issue of\n                    human skin aging is introduced, along with several pathways and the protective\n                    effects of ferulic acid in light of current patents. The complex antioxidant\n                    effect of ferulic acid depends on the \u201csweeping\u201d away of free\n                    radicals as well as the suppression of the synthesis of ROS or nitrogen.\n                    Furthermore, Cu (II) or Fe protonated metal ions are chelated by this acid (II).\n                    Ferulic acid is a free radical scavenger as well as an enzyme inhibitor,\n                    increasing the activity of enzymes that scavenge free radicals while decreasing\n                    the activity of enzymes that speed up the creation of free radicals. AMPK\n                    signalling, which can regulate cellular homeostasis, stress tolerance, cell\n                    survival and proliferation, cell death, and autophagy, has recently been linked\n                    to aging and lifespan. Therefore, Caenorhabditis elegans (C. elegans) and\n                    rodents had longer life-spans due to specific AMPK activation. By inhibiting the\n                    TGF-\u03b2\/Smad signalling pathway, UV irradiation can reduce the\n                    production of procollagen. Glycation changes the skin\u2019s physical\n                    characteristics, making it less elastic and stiffer. . Excessive free radicals\n                    simultaneously trigger the nuclear factor kappa B (NF- \u03baB) signalling\n                    pathway, increasing TNF levels and matrix metalloproteinase production\n                    (MMPs).<\/jats:p>","DOI":"10.1055\/a-2061-7129","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T19:09:41Z","timestamp":1684868981000},"page":"318-324","source":"Crossref","is-referenced-by-count":20,"title":["Ferulic Acid: Signaling Pathways in Aging"],"prefix":"10.1055","volume":"73","author":[{"given":"Deepa","family":"Neopane","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Integral University, Lucknow,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaseem Ahamad","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Integral University, Lucknow,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Integral University, Lucknow,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3390\/ijms23031238","article-title":"Protective role of melatonin and its metabolites in skin aging","volume":"23","author":"G Bocheva","year":"2022","journal-title":"International journal of molecular sciences"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3390\/antiox11061121","article-title":"Focus on the contribution of oxidative stress in skin aging","volume":"11","author":"F Papaccio","year":"2022","journal-title":"Antioxidants."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.3390\/ijms20112798","article-title":"Neuroendocrine aspects of skin aging","volume":"20","author":"G Bocheva","year":"2019","journal-title":"International journal of molecular sciences"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"119921","DOI":"10.1016\/j.lfs.2021.119921","article-title":"Ferulic acid: A review of its pharmacology, pharmacokinetics and\n                    derivatives","volume":"284","author":"D Li","year":"2021","journal-title":"Life sciences"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e00717","DOI":"10.1016\/j.btre.2022.e00717","article-title":"Ferulic acid derivatives inhibiting Staphylococcus aureus tetK and MsrA efflux\n                    pumps","volume":"34","author":"P G Pinheiro","year":"2022","journal-title":"Biotechnology Reports"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.3390\/molecules27113463","article-title":"Stability and Anti-Aging of Encapsulated Ferulic Acid in Phosphorylated Rice\n                    Starch","volume":"27","author":"J Pueknang","year":"2022","journal-title":"Molecules."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"100190","DOI":"10.1016\/j.prmcm.2022.100190","article-title":"Ferulic acid ameliorates neurodegeneration via the Nrf2\/ARE signalling\n                    pathway: A Review","author":"S Singh","year":"2022","journal-title":"Pharmacological Research-Modern Chinese Medicine"},{"key":"ref8","first-page":"4598167","article-title":"New insights for cellular and molecular mechanisms of aging and aging-related\n                    diseases: herbal medicine as potential therapeutic approach","volume":"2019","author":"Y Liu","year":"2019","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s12015-019-09880-9","article-title":"Wnt signaling mediates the aging-induced differentiation impairment of\n                    intestinal stem cells","volume":"15","author":"H Cui","year":"2019","journal-title":"Stem Cell Reviews and Reports"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"dev168351","DOI":"10.1242\/dev.168351","article-title":"WNT\/\u03b2-catenin signaling plays a crucial role in myoblast fusion\n                    through regulation of nephrin expression during development","volume":"145","author":"A Suzuki","year":"2018","journal-title":"Development."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.3390\/molecules27144351","article-title":"The molecular mechanism of polyphenols with anti-aging activity in aged human\n                    dermal fibroblasts","volume":"27","author":"J H Lee","year":"2022","journal-title":"Molecules."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.3390\/ijms20092126","article-title":"Molecular mechanisms of dermal aging and antiaging approaches","volume":"20","author":"J W Shin","year":"2019","journal-title":"International journal of molecular sciences"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1080\/09553002.2021.1962566","article-title":"Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells","volume":"97","author":"A Ry\u0161av\u00e1","year":"2021","journal-title":"International Journal of Radiation Biology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/php.12994","article-title":"Effects and Mechanism of Nicotinamide Against UVA- and\/or UVB-mediated\n                    DNA Damages in Normal Melanocytes","volume":"95","author":"G Chhabra","year":"2019","journal-title":"Photochem Photobiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e12951","DOI":"10.1111\/acel.12951","article-title":"1,25-Dihydroxyvitamin D exerts an antiaging role by activation of\n                    Nrf2-antioxidant signaling and inactivation of p16\/p53-senescence\n                    signaling","volume":"18","author":"L Chen","year":"2019","journal-title":"Aging Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3390\/cells10030660","article-title":"Key signaling pathways in aging and potential interventions for healthy\n                    aging","volume":"10","author":"M Yu","year":"2021","journal-title":"Cells."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"12489","DOI":"10.3390\/ijms222212489","article-title":"Structural and functional changes and possible molecular mechanisms in aged\n                    skin","volume":"22","author":"H Lee","year":"2021","journal-title":"International Journal of Molecular 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Alone as a Monotherapy for Photoaging","volume":"45","author":"A Chauhan","year":"2021","journal-title":"Aesthetic Plastic Surgery"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e14000","DOI":"10.1111\/dth.14000","article-title":"The effectiveness of ferulic acid and microneedling in reducing signs of\n                    photoaging: A split\u2010face comparative study","volume":"33","author":"M Z Kamila","year":"2020","journal-title":"Dermatologic Therapy"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11418-017-1120-7","article-title":"Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia\n                    tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells","volume":"72","author":"H J Park","year":"2018","journal-title":"Journal of natural medicines"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"100190","DOI":"10.1016\/j.prmcm.2022.100190","article-title":"Ferulic acid ameliorates neurodegeneration via the Nrf2\/ARE signalling\n                    pathway: A Review","author":"S Singh","year":"2022","journal-title":"Pharmacological Research-Modern Chinese Medicine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"113424","DOI":"10.1016\/j.biopha.2022.113424","article-title":"Ferulic acid ameliorates renal injury via improving autophagy to inhibit\n                    inflammation in diabetic nephropathy mice","volume":"153","author":"R Ma","year":"2022","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e00717","DOI":"10.1016\/j.btre.2022.e00717","article-title":"Ferulic acid derivatives inhibiting Staphylococcus aureus tetK and MsrA efflux\n                    pumps","volume":"34","author":"P G Pinheiro","year":"2022","journal-title":"Biotechnology Reports"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"105009","DOI":"10.1016\/j.jff.2022.105009","article-title":"Ferulic acid targets 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fibrosis via inhibition of\n                    TGF-\u03b2\/smad signalling","volume":"149","author":"S A Ali","year":"2021","journal-title":"Food and Chemical Toxicology"}],"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2061-7129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T19:29:32Z","timestamp":1688585372000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2061-7129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":33,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2023,7,5]]},"published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2061-7129","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]}}}