{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:28Z","timestamp":1740126808785,"version":"3.37.3"},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n            Ziel Offenlegung signifikanter Risikofaktoren durch Identifizierung gepoolter Effektsch\u00e4tzungsstatistiken in einer systemischen \u00dcberpr\u00fcfung und Metaanalyse klinischer und pathologischer Risikofaktoren, die ein Tumorrezidiv und ein Upstaging auf eine zweite TURBT bei Patienten mit hochgradigem NMIBC vorhersagen.\n    <\/jats:p><jats:p>\n            Material-Methode Alle Datenquellen wurden umfassend bis Oktober 2022 untersucht. Die Daten wurden aus den relevanten Studien extrahiert und mit der Software RevMan analysiert. In einem inversen Varianzmodell mit zuf\u00e4lligen und festen Effekten werden Odds Ratio (OR)-Werte mit 95%-Konfidenzintervallen [95%-KI] angegeben.\n    <\/jats:p><jats:p>\n            Ergebnisse Der Review umfasste insgesamt 18 Studien und 4548 Patienten. Gem\u00e4\u00df den gepoolten Effektsch\u00e4tzern waren Carcinoma in situ (CIS), Tumorgrad, Multiplizit\u00e4t und Chirurgenfaktoren signifikante Risikofaktoren. Die gepoolten Effektsch\u00e4tzungen f\u00fcr das Tumorstadium und die Tumormorphologie waren sehr nahe an der Signifikanz. F\u00fcr CIS, Grad, Multiplizit\u00e4t und Chirurgenfaktor, OR, IVR oder IVF [95%-KI] waren die p- und I2-Werte 1,8 [1,1, 3,0], 0,03, 75%; 2 [1,1, 3,4], 0,02, 53%; 1,3 [1,2, 1,6], &lt;0,01, 40%; und 2 [1,4, 3], &lt;0,01, 66%.\n    <\/jats:p><jats:p>\n            Schlussfolgerungen Als Ergebnis der ersten TURBT; Eine zweite TURBT sollte in den 2\u20136 Wochen der postoperativen Phase f\u00fcr Patienten mit hochgradigem, begleitendem CIS, multipler, solider Morphologie, DM(-) im pathologischen Pr\u00e4parat und NMIBC, das von Trainern\/Juniorchirurgen operiert wird, geplant werden.\n    <\/jats:p>","DOI":"10.1055\/a-2063-3144","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T22:54:28Z","timestamp":1685660068000},"page":"30-40","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and pathological risk factors for tumour recurrence and upstaging in second TURBT for patients with NMIBC: a systematic review and meta-analysis"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-8013","authenticated-orcid":false,"given":"Yavuz","family":"Guler","sequence":"additional","affiliation":[{"name":"Department of Urology, TC Istanbul Rumeli University, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.eururo.2005.12.031.4","article-title":"Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials","volume":"49","author":"RJ Sylvester","year":"2006","journal-title":"Eur Urol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0302-2838(03)00040-X","article-title":"The value of a second transurethral resection in evaluating patients with bladder tumours","volume":"43","author":"M Miladi","year":"2003","journal-title":"Eur Urol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"272","DOI":"10.4081\/aiua.2017.4.272","article-title":"Can re-TURBT be useful in pT1HG diseaseas a risk indicator of recurrence and progression? 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