{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T18:10:49Z","timestamp":1774635049071,"version":"3.50.1"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Trotz Weiterentwicklungen in interdisziplin\u00e4rer Diagnostik und Therapie stellen komplexe Analfisteln bei Morbus Crohn weiterhin eine Herausforderung f\u00fcr medikament\u00f6se und chirurgische\n            Therapiekonzepte dar. Konventionelle chirurgische Techniken (u.\u00a0a. Flap, LIFT) sind mit relativ hohen Persistenz- und Rezidivraten vergesellschaftet. Vor diesem Hintergrund zeigen\n            Ergebnisse der Stammzelltherapie eine vielversprechende, sphinkterschonende Therapieoption. Insbesondere die allogene mesenchymale Stammzelltherapie (Darvadstrocel) konnte im Rahmen der\n            randomisierten ADMIRE-CD-Studie eine hohe Wirksamkeit bei komplexen Crohn-Fisteln zeigen, die auch in limitierten \u201eReal-World\u201c-Daten reproduziert werden konnte. Die aktuelle Evidenz der\n            allogenen mesenchymalen Stammzellen hat hierbei auch Einzug in internationale Leitlinien erhalten. Inwieweit die allogene mesenchymale Stammzelltherapie in Zukunft eine effektive\n            Therapieoption im interdisziplin\u00e4ren Management der komplexen perianalen Fistel bei Morbus Crohn darstellt, kann derzeit noch nicht definitiv bewertet werden.<\/jats:p>","DOI":"10.1055\/a-2063-3673","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T22:40:17Z","timestamp":1685745617000},"page":"220-227","source":"Crossref","is-referenced-by-count":4,"title":["Stammzelltherapie bei komplexen perianalen Fisteln bei Morbus Crohn: Aktuelle Evidenz und Ausblick"],"prefix":"10.1055","volume":"148","author":[{"given":"Oliver","family":"Schwandner","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Proktologie, Krankenhaus Barmherzige Br\u00fcder, Regensburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2147\/CEG.S108513","article-title":"Perianal Crohn\u2019s disease: challenges and solutions","volume":"10","author":"KA Kelley","year":"2017","journal-title":"Clin Exp Gastroenterol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.4291\/wjgp.v5.i3.205","article-title":"Pathophysiology of fistula formation in Crohn\u2019s disease","volume":"5","author":"M Scharl","year":"2014","journal-title":"World J Gastroenterol Pathophysiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.3748\/wjg.v24.i42.482","article-title":"Burden and outcomes for complex perianal fistulas in Crohn\u2019s disease: systematic review","volume":"24","author":"J Panes","year":"2018","journal-title":"World J Gastroenterol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1097\/DCR.0000000000001748","article-title":"Perianal Crohn\u2019s disease","volume":"63","author":"AL Lightner","year":"2020","journal-title":"Dis Colon Rectum"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/j.gastro.2003.08.025","article-title":"; American Gatroenterological Association Clinical Practice Committee. 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