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Eighteen phenolic compounds including some rare secondary metabolites, such as irisolidone, kikkalidone, irigenin, irisolone,\n          germanaism B, kaempferol, and xanthone mangiferin, were isolated for the first time from Iris aphylla rhizomes. The hydroethanolic Iris aphylla extract and some of its isolated\n          constituents showed protective effects against influenza H1N1 and enterovirus D68 and anti-inflammatory activity in human neutrophils. The promising anti-influenza effect of apigenin\n          (13, almost 100% inhibition at 50\u2009\u00b5M), kaempferol (14, 92%), and quercetin (15, 48%) were further confirmed by neuraminidase inhibitory assay. Irisolidone (1,\n          almost 100% inhibition at 50\u2009\u00b5M), kikkalidone (5, 93%), and kaempferol (14, 83%) showed promising anti-enterovirus D68 activity in vitro. The identified compounds were\n          plotted using ChemGPS-NP to correlate the observed activity of the isolated phenolic compounds with the in-house database of anti-influenza and anti-enterovirus agents. Our results indicated\n          that the hydroethanolic Iris aphylla extract and Iris phenolics hold the potential to be developed for the management of seasonal pandemics of influenza and enterovirus\n          infections.<\/jats:p>","DOI":"10.1055\/a-2063-5265","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T23:32:25Z","timestamp":1680046345000},"page":"1063-1073","source":"Crossref","is-referenced-by-count":3,"title":["Anti-viral and Anti-inflammatory Isoflavonoids from Ukrainian Iris aphylla Rhizomes: Structure-Activity Relationship Coupled with ChemGPS-NP Analysis"],"prefix":"10.1055","volume":"89","author":[{"given":"Olha","family":"Mykhailenko","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, National University of Pharmacy of Ministry of Health of Ukraine, Kharkiv, Ukraine"},{"name":"Pharmacognosy and Phytotherapy Group, UCL School of Pharmacy, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Fan","family":"Hsieh","sequence":"first","affiliation":[{"name":"Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"},{"name":"Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"El-Shazly","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, African Union Organization Street, Abbassia, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Nikishin","sequence":"additional","affiliation":[{"name":"V.\u200aN. Karazin Kharkiv National University, Organic Chemistry Department, Kharkiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Kovalyov","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, National University of Pharmacy of Ministry of Health of Ukraine, Kharkiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavlo","family":"Shynkarenko","sequence":"additional","affiliation":[{"name":"Enamine Ltd, Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liudas","family":"Ivanauskas","sequence":"additional","affiliation":[{"name":"Lithuanian University of Health Sciences, Department of Analytical and Toxicological Chemistry, Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science, Kaohsiung, Taiwan"},{"name":"The Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim-Tong","family":"Horng","sequence":"additional","affiliation":[{"name":"Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"},{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"},{"name":"Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan, Taiwan"},{"name":"Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan"},{"name":"Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsong-Long","family":"Hwang","sequence":"additional","affiliation":[{"name":"Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan"},{"name":"Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan"},{"name":"Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"},{"name":"Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoriya","family":"Georgiyants","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, National University of Pharmacy of Ministry of Health of Ukraine, Kharkiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8988-8610","authenticated-orcid":false,"given":"Michal","family":"Korinek","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science, Kaohsiung, Taiwan"},{"name":"Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"},{"name":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41392-021-00527-1","article-title":"COVID-19 in early 2021: Current status and looking forward","volume":"6","author":"C Wang","year":"2021","journal-title":"Signal Transduct Target 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