{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:27:33Z","timestamp":1781526453302,"version":"3.54.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study is an investigation of aggressive tumor features, prognosis, and\n                    disease-specific mortality rates of differentiated thyroid cancer (DTC) in the\n                    presence of concomitant Hashimoto\u2019s Thyroiditis (HT). The data of\n                    patients with DTC followed in our tertiary care center between 2000\u20132022\n                    were analyzed. Variables such as patient age, gender, preoperative serum\n                    autoantibody levels, tumor characteristics, and treatment modalities were\n                    obtained from medical records. The diagnosis of HT was based either on the\n                    presence of a positive result in the pathological examination and\/or on\n                    antibody positivity. A total of 637 patients [mean\u00b1SD age,\n                    44.9\u00b113.5 years; 485 women [76.1%)] were included in the\n                    analysis. The overall prevalence of coexistent HT was 22.9%\n                    (n=146). The disease-specific mortality associated with DTC was\n                    2.9%. DTC patients with HT compared to those without; have more positive\n                    lymphovascular invasion (p&lt;0.001), and lymph node metastases\n                    (p&lt;0.001). According to the Kaplan\u2013Meier curves,\n                    disease-specific survival rates among DTC patients without HT were significantly\n                    higher than patients with HT (log-rank p=0.002). The disease-specific\n                    mortality rate was 4.79% in DTC patients with HT, it was 1.43%\n                    in those without HT. Hashimoto thyroiditis was not associated with a 10-year\n                    recurrence-free survival (p=0.059). Differentiated thyroid cancers with\n                    concomitant HT are associated with some aggressive tumor features (such as\n                    lymphovascular invasion and nodal metastasis) and lower survival. In staging\n                    systems based on tumor risk factors, it may be useful to evaluate the presence\n                    of concomitant HT as a prognostic factor.<\/jats:p>","DOI":"10.1055\/a-2065-0845","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T23:55:01Z","timestamp":1680134101000},"page":"388-394","source":"Crossref","is-referenced-by-count":5,"title":["Does the Association of Hashimoto's Thyroiditis with\n                    Differentiated Thyroid Cancer Really Have a Protective Role?"],"prefix":"10.1055","volume":"55","author":[{"given":"Ahmet Numan","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Diabetes, Istanbul\n                    University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Diabetes, Istanbul\n                    University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Sulu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Diabetes, Istanbul\n                    University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhat","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Diabetes, Istanbul\n                    University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Diabetes, Istanbul\n                    University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guldana","family":"Zulfaliyeva","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Istanbul University-Cerrahpasa,\n                    Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oznur Aydin","family":"Atar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Istanbul University-Cerrahpasa,\n                    Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahida","family":"Valikhanova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Istanbul University-Cerrahpasa,\n                    Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulin","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology, Istanbul University-Cerrahpasa,\n                    Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hande Mefkure","family":"Ozkaya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Diabetes, Istanbul\n                    University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Sait","family":"Gonen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, and Diabetes, Istanbul\n                    University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with\n                    thyroid nodules and differentiated thyroid cancer: The American Thyroid\n                    Association 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2065-0845.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T23:20:35Z","timestamp":1686352835000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2065-0845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":27,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2023,6,9]]},"published-print":{"date-parts":[[2023,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2065-0845","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,29]]},"published":{"date-parts":[[2023,3,29]]}}}