{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:09Z","timestamp":1740126849111,"version":"3.37.3"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"S 01","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003The coronavirus disease 2019 (COVID-19) pandemic had a significant impact on pregnant women and neonates in Iran. This retrospective study describes the national experience among neonates having suspected and confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection following hospital admission to examine the epidemiology, demographic, and clinical features.<\/jats:p><jats:p>\n            Study Design\u2003All nationwide cases of suspected and confirmed neonatal SARS-CoV-2 infection were drawn from the Iranian Maternal and Neonatal Network (IMaN) between February 2020 and February 2021. IMaN registers demographic, maternal, and neonatal health data throughout Iran. Statistical analysis of demographic, epidemiological, and clinical data were performed.<\/jats:p><jats:p>\n            Results\u2003There were 4,015 liveborn neonates having suspected or confirmed SARS-CoV-2 infection that fulfilled the study inclusion criteria identified in the IMaN registry from 187 hospitals throughout Iran. There were 1,392 (34.6%) neonates that were preterm, including 304 (7.6%) less than 32 weeks' gestation. Among the 2,567 newborns admitted to the hospital immediately after birth, the most common clinical problems were respiratory distress (1,095 cases; 42.6%), sepsis-like syndrome (355; 13.8%), and cyanosis (300 cases; 11.6%). Of 683 neonates transferred from another hospital, the most frequent problems were respiratory distress (388; 56.8%), sepsis-like syndrome (152; 22.2%), and cyanosis (134; 19.6%). Among 765 neonates discharged home after birth and subsequently admitted to the hospital, sepsis-like syndrome (244 cases; 31.8%), fever (210; 27.4%), and respiratory distress (185; 24.1%) were most frequent. A total of 2,331 (58%) of neonates required respiratory care, with 2,044 surviving and 287 having a neonatal death. Approximately 55% of surviving neonates received respiratory support, compared with 97% of neonates who expired. Laboratory abnormalities included elevations of white blood cell count, creatine phosphokinase, liver enzymes, and C-reactive protein.<\/jats:p><jats:p>\n            Conclusion\u2003This report adds the national experience of Iran to the list of reports from multiple countries describing their experience with COVID-19 in neonates, demonstrating that newborns are not exempt from COVID-19-morbidity and mortality.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-2065-4714","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T23:53:31Z","timestamp":1680134011000},"page":"e1698-e1708","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Epidemiology and Clinical Features of COVID-19 among 4,015 Neonates in Iran: Results of the National Study from the Iranian Maternal and Neonatal Network"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-8545","authenticated-orcid":false,"given":"David A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Perinatal Pathology Consulting, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parisa","family":"Mohagheghi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fereshteh","family":"Moshfegh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazanin","family":"Zafaranloo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Omid Hospital, Iran University of Medical and Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narjes","family":"Khalili","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine, Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Heidarzadeh","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Habibelahi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Neonatal Health Office, Ministry of Health IR, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roya","family":"Ghafoury","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, Iran University of Medical and Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Afrashteh","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, Iran University of Medical and Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"ref1","first-page":"97","article-title":"COVID-19 in Iran: what was done and what should be done","volume":"35","author":"M Nojomi","year":"2021","journal-title":"Med J Islam Repub Iran"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ijgo.13700","article-title":"The severity of COVID-19 among pregnant women and the risk of adverse maternal outcomes","volume":"154","author":"P Samadi","year":"2021","journal-title":"Int J Gynaecol 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Schwartz","year":"2022","journal-title":"Viruses"},{"issue":"03","key":"ref35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ajog.2022.10.001","article-title":"SARS-CoV-2 placentitis, stillbirth and maternal COVID-19 vaccination: clinical-pathological correlations","volume":"228","author":"D A Schwartz","year":"2023","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref36","doi-asserted-by":"crossref","first-page":"660","DOI":"10.5858\/arpa.2022-0029-SA","article-title":"Placental tissue destruction and insufficiency from COVID-19 causes stillbirth and neonatal death from hypoxic-ischemic injury","volume":"146","author":"D A Schwartz","year":"2022","journal-title":"Arch Pathol Lab Med"},{"issue":"01","key":"ref37","doi-asserted-by":"crossref","first-page":"e104423","DOI":"10.5812\/ijp.104423","article-title":"COVID-19 in neonates: a review","volume":"31","author":"M Saeedi","year":"2020","journal-title":"Iran J 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More definitive evidence is needed","volume":"323","author":"D W Kimberlin","year":"2020","journal-title":"JAMA"},{"issue":"01","key":"ref42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00404-021-06049-z","article-title":"A systematic review of pregnant women with COVID-19 and their neonates","volume":"304","author":"M Mirbeyk","year":"2021","journal-title":"Arch Gynecol Obstet"},{"issue":"14","key":"ref43","first-page":"7804","article-title":"Clinical outcomes of 201 neonates born to mothers with COVID-19: a systematic review","volume":"24","author":"S H Yoon","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"06","key":"ref44","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/pathogens9060485","article-title":"COVID-19 in pregnant women and neonates: a systematic review of the literature with quality assessment of the studies","volume":"9","author":"G Trippella","year":"2020","journal-title":"Pathogens"},{"issue":"06","key":"ref45","doi-asserted-by":"crossref","first-page":"e20200702","DOI":"10.1542\/peds.2020-0702","article-title":"Epidemiology of COVID-19 among children in China","volume":"145","author":"Y Dong","year":"2020","journal-title":"Pediatrics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"580584","DOI":"10.3389\/fped.2020.580584","article-title":"Neonatal infection due to SARS-CoV-2: an epidemiological study in Spain","volume":"8","author":"B Fern\u00e1ndez Colomer","year":"2020","journal-title":"Front Pediatr"},{"issue":"10","key":"ref47","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S2352-4642(20)30235-2","article-title":"Neonatal management and outcomes during the COVID-19 pandemic: an observation cohort study","volume":"4","author":"C M Salvatore","year":"2020","journal-title":"Lancet Child Adolesc Health"},{"issue":"07","key":"ref48","doi-asserted-by":"crossref","first-page":"taaa158","DOI":"10.1093\/jtm\/taaa158","article-title":"Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study","volume":"27","author":"R Pirjani","year":"2020","journal-title":"J Travel Med"},{"issue":"08","key":"ref49","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/jamapediatrics.2021.1050","article-title":"Maternal and neonatal morbidity and mortality among pregnant women with and without COVID-19 infection: the INTERCOVID Multinational Cohort Study","volume":"175","author":"J Villar","year":"2021","journal-title":"JAMA Pediatr"},{"issue":"01","key":"ref50","doi-asserted-by":"crossref","first-page":"e0262202","DOI":"10.1371\/journal.pone.0262202","article-title":"Impact of the COVID-19 pandemic on neonatal admissions in a tertiary children's hospital in southwest China: an interrupted time-series study","volume":"17","author":"W Liu","year":"2022","journal-title":"PLoS One"},{"issue":"47","key":"ref51","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.15585\/mmwr.mm7047e1","article-title":"Risk for stillbirth among women with and without COVID-19 at delivery hospitalization\u2014United States, March 2020\u2013September 2021","volume":"70","author":"C L DeSisto","year":"2021","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/s41372-022-01467-6","article-title":"Preterm birth among pregnant persons with severe acute respiratory syndrome coronavirus 2 infection","volume":"42","author":"S M Newton","year":"2022","journal-title":"J Perinatol"},{"issue":"01","key":"ref53","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s12884-021-03742-4","article-title":"The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis","volume":"21","author":"O Martinez-Perez","year":"2021","journal-title":"BMC Pregnancy Childbirth"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2065-4714.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:29:20Z","timestamp":1730813360000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2065-4714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":50,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2065-4714","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published-other":{"date-parts":[[2023,3,29]]},"published":{"date-parts":[[2023,3,29]]}}}