{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T06:58:42Z","timestamp":1770793122812,"version":"3.50.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n            Hintergrund Aktuell wurde mit dem Tetrafecta-Score das erste Instrument zur Beurteilung der Behandlungsqualit\u00e4t in der chirurgischen Prim\u00e4rtherapie des Peniskarzinoms (PECa) publiziert. Eine externe wissenschaftliche Auseinandersetzung mit den ihn definierenden Einzelkriterien steht bislang noch aus und bildet das Studienziel.\n    <\/jats:p><jats:p>\n            Material und Methode Es wurde eine internationale Arbeitsgruppe bestehend aus 12 Urologen und einem Onkologen mit klinischer und akademisch-wissenschaftlicher Expertise auf dem Gebiet des Peniskarzinoms gegr\u00fcndet. In einem modifizierten vierstufigen Delphi-Prozess wurden unter Einbeziehung der Tetrafecta-Kriterien insgesamt 13 Kriterien f\u00fcr PECa-Patienten in den klinischen AJCC-Stadien 1\u20134 (T1\u20133N0\u20133, aber M0) definiert, von denen in einer geheimen Abstimmung jeder der Experten 5 ausw\u00e4hlen musste, um dadurch einen individuellen Pentafecta-Score zu generieren. Anschlie\u00dfend wurde das Rating der Experten aggregiert ausgewertet und dadurch ein finaler Pentafecta-Score gebildet.\n    <\/jats:p><jats:p>\n            Ergebnisse Keines der urspr\u00fcnglichen Tetrafecta-Kriterien wurde in den finalen Pentafecta-Score \u00fcbernommen, der sich aus den folgenden Kriterien zusammensetzt: 1.) Organerhalt, sofern immer m\u00f6glich (\u2264T2), jedoch stets unter Wahrung eines negativen chirurgischen Schnittrandes, 2.) beidseitige inguinale Lymphadenektomie (ILAE) ab pT1G2N0, 3.) perioperative Chemotherapie sollte erfolgen, sofern durch die Leitlinien indiziert, 4.) ILAE sollte, sofern indiziert, in einem zeitlichen Abstand von maximal 3 Monaten zur Prim\u00e4rtumorresektion erfolgen und 5.) die behandelnde Klinik sollte im Minimum 15 chirurgische Prim\u00e4rtherapien bei PECa-Patienten durchf\u00fchren. Nur 7 der 13 Experten (54%) zeigten eine starke Korrelation ihres individuellen mit dem finalen Pentafecta-Score (rsp &gt;0.60).\n    <\/jats:p><jats:p>\n            Schlussfolgerung Auf der Basis eines moderierten Abstimmungsprozesses unter internationalen PECa-Experten wurde ein Pentafecta-Score als Qualit\u00e4tssicherungs-Instrument f\u00fcr die chirurgische Prim\u00e4rtherapie gebildet, der nun anhand von patientenrelevanten und patientenberichteten Endpunkten zu validieren ist.\n    <\/jats:p>","DOI":"10.1055\/a-2065-8256","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T22:48:57Z","timestamp":1687301337000},"page":"292-298","source":"Crossref","is-referenced-by-count":3,"title":["Erstvorstellung des Pentafecta-Scores als Qualit\u00e4tsinstrument der Outcome-Bewertung einer chirurgischen Prim\u00e4rtherapie an Patienten mit Peniskarzinom"],"prefix":"10.1055","volume":"54","author":[{"given":"Matthias","family":"May","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Urologie, St. Elisabeth Klinikum Straubing, Straubing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Lebentrau","sequence":"first","affiliation":[{"name":"Urology, Otto-von-Guericke-Universit\u00e4t Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Ayres","sequence":"first","affiliation":[{"name":"Department of Urology, St George's University Hospitals NHS, London, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe E.","family":"Spiess","sequence":"first","affiliation":[{"name":"Department of Urology, H. Lee Moffitt Cancer Center, Tampa, FL, Tampa, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Watkin","sequence":"additional","affiliation":[{"name":"Department of Urology, St George's University Hospitals NHS, London, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten","family":"Albersen","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospitals Leuven, Leuven, Leuven, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Protzel","sequence":"additional","affiliation":[{"name":"Urologie, HELIOS Kliniken Schwerin, Schwerin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jad","family":"Chahoud","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, Tampa, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar R.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis A.","family":"Pettaway","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Texas MD Anderson Cancer Center, Houston, Houston, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance C.","family":"Pagliaro","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN, Rochester, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Necchi","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS San Raffaele Hospital and Scientific Institute, Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver W.","family":"Hakenberg","sequence":"additional","affiliation":[{"name":"Urology, Universit\u00e4tsmedizin Rostock (A\u00f6R), Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1089\/end.2017.0369","article-title":"Predictive Factors for Achieving Superior Pentafecta Outcomes Following Robot-Assisted Partial Nephrectomy in Patients with Localized Renal Cell Carcinoma","volume":"31","author":"M Kang","year":"2017","journal-title":"J Endourol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41598-021-04289-2","article-title":"Two-year quality of life after robot-assisted radical prostatectomy according to pentafecta criteria and cancer of the prostate risk assessment (CAPRA-S)","volume":"12","author":"T Karagiotis","year":"2022","journal-title":"Sci Rep"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1007\/s00345-015-1572-x","article-title":"Optimizing outcome reporting after radical cystectomy for organ-confined urothelial carcinoma of the bladder using oncological trifecta and pentafecta","volume":"33","author":"A Aziz","year":"2015","journal-title":"World J Urol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3390\/curroncol30020146","article-title":"Combined Reporting of Surgical Quality and Cancer Control after Surgical Treatment for Penile Tumors with Inguinal Lymph Node Dissection: The Tetrafecta Achievement","volume":"30","author":"A Brassetti","year":"2023","journal-title":"Current Oncology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"840367","DOI":"10.3389\/fonc.2022.840367","article-title":"The Development and Validation of a Nomogram Incorporating Clinical, Pathological, and Therapeutic Features to Predict Overall Survival in Patients With Penile Cancer: A SEER-Based Study","volume":"12","author":"R Li","year":"2022","journal-title":"Front Oncol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1097\/JU.0000000000000584","article-title":"Prognosis of the 8th TNM Staging System for Penile Cancer and Refinement of Prognostication by Incorporating High Risk Human Papillomavirus Status","volume":"203","author":"B Wang","year":"2020","journal-title":"J Urol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"706531","DOI":"10.3389\/fonc.2021.706531","article-title":"Impact of Examined Lymph Node Count and Lymph Node Density on Overall Survival of Penile Cancer","volume":"11","author":"P Gao","year":"2021","journal-title":"Front Oncol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1097\/MOU.0000000000000803","article-title":"Volume outcome relationship in penile cancer: a systematic review","volume":"30","author":"F Quhal","year":"2020","journal-title":"Curr Opin Urol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"759362","DOI":"10.3389\/fonc.2021.759362","article-title":"Does the Identification of a Minimum Number of Cases Correlate With Better Adherence to International Guidelines Regarding the Treatment of Penile Cancer? 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