{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:55:49Z","timestamp":1792533349136,"version":"4.5.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and study aims\u2002Z-POEM is now an established therapy for symptomatic Zenker\u2019s diverticulum (ZD). Short-term follow-up of up to 1-year post Z-POEM suggests excellent efficacy and safety; however, long-term outcomes are not known. Thus, we sought to report on longer-term outcomes (\u2265\u200a2 years) following Z-POEM for treatment of ZD.<\/jats:p>\n                  <jats:p>Patients and methods\u2002This was an International multicenter retrospective study at eight institutions across North America, Europe, and Asia over a 5-year period (from December 3, 2015 to March 13, 2020) of patients who underwent Z-POEM for management of ZD with a minimum 2-year follow-up.\u200aThe primary outcome was clinical success, defined as improvement in dysphagia score to \u2264\u200a1 without need for further procedures during the first 6 months. Secondary outcomes included rate of recurrence in patients initially meeting clinical success, rate of reintervention, and adverse events (AEs).<\/jats:p>\n                  <jats:p>Results\u2002A total of 89 patients (male 57.3\u200a%, mean age 71\u200a\u00b1\u200a12 years) underwent Z-POEM for treatment of ZD (mean diverticulum size was 3.4\u200a\u00b1\u200a1.3\u200acm). Technical success was achieved in 97.8\u200a% of patients (n\u200a=\u200a87) with a mean procedure time of 43.8\u200a\u00b1\u200a19.2 minutes. The median post-procedure hospital stay was 1 day. There were eight AEs (9\u200a%) (3 mild, 5 moderate). Overall, clinical success was achieved in 84 patients (94\u200a%). Mean dysphagia, regurgitation, and respiratory scores all improved dramatically from 2.1\u200a\u00b1\u200a0.8, 2.8\u200a\u00b1\u200a1.3, and 1.8\u200a\u00b1\u200a1.6 pre-procedure to 0.13\u200a\u00b1\u200a0.5, 0.11\u200a\u00b1\u200a0.5, and 0.05\u200a\u00b1\u200a0.4, respectively, post-procedure at most recent follow-up (all P\u200a&lt;\u200a0.0001). Recurrence occurred in six patients (6.7\u200a%) during a mean length of follow-up of 37 months (range 24 to 63 months).<\/jats:p>\n                  <jats:p>Conclusions\u2002Z-POEM is a highly safe and effective treatment for Zenker\u2019s diverticulum with durable treatment effect to at least 2 years.<\/jats:p>","DOI":"10.1055\/a-2067-9105","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T19:26:06Z","timestamp":1680549966000},"page":"E607-E612","source":"Crossref","is-referenced-by-count":51,"title":["Long-term outcomes of Zenker\u2019s peroral endoscopic myotomy (Z-POEM) for treatment of Zenker\u2019s diverticulum"],"prefix":"10.1055","volume":"11","author":[{"given":"Steven","family":"Steinway","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medicine, Gastroenterology and Hepatology, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Zhang","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medicine, Gastroenterology and Hepatology, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Amundson","sequence":"additional","affiliation":[{"name":"University of Chicago Pritzker School of Medicine, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Nieto","sequence":"additional","affiliation":[{"name":"University of Central Florida, Department of Gastroenterology, Orlando, Florida, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Desai","sequence":"additional","affiliation":[{"name":"Surat Institute of Digestive Sciences, GI Endoscopy, Surat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremie","family":"Jacques","sequence":"additional","affiliation":[{"name":"CHU Dupytren Limoges, Service d\u2019H\u00e9pato-gastro-ent\u00e9rologie, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bejjani","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medicine, Gastroenterology and Hepatology, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Pioche","sequence":"additional","affiliation":[{"name":"H\u00f4pital Edouard Herriot, Endoscopy Unit, Digestive Disease Department, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Kumta","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Hernandez-Mondragon","sequence":"additional","affiliation":[{"name":"IMSS, Digestive Endoscopy, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ujiki","sequence":"additional","affiliation":[{"name":"NorthShore University Health Systems, NorthShore Center for Simulation and Innovation, Evanston, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouen","family":"Khashab","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medicine, Gastroenterology and Hepatology, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"ref1","first-page":"219","article-title":"Zenker\u02bcs diverticulum: exploring treatment options","volume":"33","author":"A Bizzotto","year":"2013","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000351433","article-title":"Surgical treatment of Zenker\u02bcs diverticulum","volume":"30","author":"Y Yuan","year":"2013","journal-title":"Dig Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00405-009-1079-4","article-title":"Surgical treatment of hypopharyngeal diverticulum (Zenker\u02bcs diverticulum)","volume":"267","author":"T Keck","year":"2010","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"719","DOI":"10.4065\/mcp.2009.0663","article-title":"Flexible endoscopic management of Zenker diverticulum: the Mayo Clinic experience","volume":"85","author":"D J Case","year":"2010","journal-title":"Mayo Clin Proc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"E678","DOI":"10.1055\/s-0042-106203","article-title":"Endoscopic versus surgical 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Preliminary results from a single-center experience","volume":"27","author":"G Battaglia","year":"2015","journal-title":"Dig Endosc"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.gie.2020.05.064","article-title":"Clinical utility of cricopharyngeal distensibility measurements during endoscopic myotomy for Zenker\u02bcs diverticulum","volume":"93","author":"L Y Zhang","year":"2021","journal-title":"Gastrointest Endosc"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.gie.2009.10.027","article-title":"A lexicon for endoscopic adverse events: report of an ASGE workshop","volume":"71","author":"P B Cotton","year":"2010","journal-title":"Gastrointest Endosc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/dote.12323","article-title":"Flexible endosopic management of Zenker\u02bcs diverticulum: characteristics and outcomes of 52 cases at a tertiary referral center","volume":"29","author":"M Halland","year":"2016","journal-title":"Dis Esophagus"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1007\/s00405-014-3267-0","article-title":"Systematic review on treatment of Zenker\u02bcs diverticulum","volume":"272","author":"J Verdonck","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref22","first-page":"628","article-title":"Endoscopic treatment of zenker diverticulum","volume":"6","author":"A Repici","year":"2010","journal-title":"Gastroenterol Hepatol (NY)"}],"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2067-9105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T19:05:06Z","timestamp":1688065506000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2067-9105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":22,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2023,6,9]]},"published-print":{"date-parts":[[2023,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2067-9105","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4,3]]},"published":{"date-parts":[[2023,4,3]]}}}